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Three-time-point PET analysis of 68Ga-FAPI-46 in a variety of cancers

A growing family of 68Ga-fibroblast activation protein inhibitor (FAPI) PET probes has shown promise in imaging a variety of medical conditions. 68Ga-FAPI-46, in particular, has emerged as unique for both its diagnostic and its theranostic applications; however, the optimal timing of PET remains unc...

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Hauptverfasser: Naeimi, Mahnoosh (VerfasserIn) , Choyke, Peter L. (VerfasserIn) , Dendl, Katharina (VerfasserIn) , Mori, Yuriko (VerfasserIn) , Staudinger, Fabian (VerfasserIn) , Watabe, Tadashi (VerfasserIn) , Körber, Stefan A. (VerfasserIn) , Röhrich, Manuel (VerfasserIn) , Debus, Jürgen (VerfasserIn) , Kratochwil, Clemens (VerfasserIn) , Haberkorn, Uwe (VerfasserIn) , Giesel, Frederik L. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: April 1, 2023
In: Journal of nuclear medicine
Year: 2023, Jahrgang: 64, Heft: 4, Pages: 618-622
ISSN:2159-662X
DOI:10.2967/jnumed.122.264941
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Verfasserangaben:Mahnoosh Naeimi, Peter L. Choyke, Katharina Dendl, Yuriko Mori, Fabian Staudinger, Tadashi Watabe, Stefan A. Koerber, Manuel Röhrich, Jürgen Debus, Clemens Kratochwil, Uwe Haberkorn, Frederik L. Giesel
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Zusammenfassung:A growing family of 68Ga-fibroblast activation protein inhibitor (FAPI) PET probes has shown promise in imaging a variety of medical conditions. 68Ga-FAPI-46, in particular, has emerged as unique for both its diagnostic and its theranostic applications; however, the optimal timing of PET remains unclear. Therefore, we evaluated uptake at 3 time points after 68Ga-FAPI-46 administration in a spectrum of tumor types. Methods: The cohort consisted of 43 patients with diverse cancer diagnoses undergoing 68Ga-FAPI-46 PET/CT at 3 time points (10 min, 1 h, and 3 h). We determined the tracer uptake based on SUVmean and SUVmax and on tumor-to-background-ratios (TBRs) (SUVmax/SUVmean). Results: There were 171 lesions in the 43 patients. Comparing all lesions at different time points, the mean SUVmax was maximal at 10 min (8.2) and declined slightly at 1 h (8.15) and 3 h (7.6) after tracer administration. Similarly, the mean SUVmax log still had a similar pattern in primary lesions at 10 min, 1 h, and 3 h (n = 30; 0.98, 1.01, and 0.98, respectively), lymph node metastases (n = 37; 0.82, 0.84, and 0.81, respectively), and distant metastases (n = 104; 0.81, 0.79, and 0.74, respectively). TBR also showed nonsignificant differences at the 3 times. Conclusion: 68Ga-FAPI-46 PET/CT imaging revealed remarkably stable tumor and background uptake as determined by SUV metrics and maintained high TBRs within 3 h of injection. Thus, it may be possible to scan with 68Ga-FAPI-46 within 10-20 min of injection, improving workflow and decreasing patient wait times. Confirmation of these findings in a larger cohort is under way.
Beschreibung:Online veröffentlicht: 3. April 2023
Gesehen am 10.08.2023
Im Titel ist die Zahl 68 hochgestellt
Beschreibung:Online Resource
ISSN:2159-662X
DOI:10.2967/jnumed.122.264941

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