Buchumschlag

Selection of pfmdr1 and pfcrt alleles in amodiaquine treatment failure in north-western Burkina Faso

In 111 children under five years of age and with uncomplicated malaria in Nouna, north-western Burkina Faso, amodiaquine treatment failed in 75% (after PCR-based exclusion of new infections, 32%). In these, we assessed the role of Plasmodium falciparum pfmdr1 and pfcrt polymorphisms in amodiaquine r...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Danquah, Ina (VerfasserIn) , Coulibaly, Boubacar (VerfasserIn) , Meissner, Peter (VerfasserIn) , Petruschke, Inga (VerfasserIn) , Müller, Olaf (VerfasserIn) , Mockenhaupt, Frank Peter (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 7 January 2010
In: Acta tropica
Year: 2010, Jahrgang: 114, Heft: 1, Pages: 63-66
ISSN:1873-6254
DOI:10.1016/j.actatropica.2009.12.008
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.actatropica.2009.12.008
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0001706X10000021
Volltext
Verfasserangaben:Ina Danquah, Boubacar Coulibaly, Peter Meissner, Inga Petruschke, Olaf Müller, Frank P. Mockenhaupt

MARC

LEADER 00000caa a2200000 c 4500
001 185512937X
003 DE-627
005 20240612071851.0
007 cr uuu---uuuuu
008 230810s2010 xx |||||o 00| ||eng c
024 7 |a 10.1016/j.actatropica.2009.12.008  |2 doi 
035 |a (DE-627)185512937X 
035 |a (DE-599)KXP185512937X 
035 |a (OCoLC)1425874394 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Danquah, Ina  |d 1982-  |e VerfasserIn  |0 (DE-588)115451353X  |0 (DE-627)101580618X  |0 (DE-576)501055223  |4 aut 
245 1 0 |a Selection of pfmdr1 and pfcrt alleles in amodiaquine treatment failure in north-western Burkina Faso  |c Ina Danquah, Boubacar Coulibaly, Peter Meissner, Inga Petruschke, Olaf Müller, Frank P. Mockenhaupt 
264 1 |c 7 January 2010 
300 |a 4 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 10.08.2023 
520 |a In 111 children under five years of age and with uncomplicated malaria in Nouna, north-western Burkina Faso, amodiaquine treatment failed in 75% (after PCR-based exclusion of new infections, 32%). In these, we assessed the role of Plasmodium falciparum pfmdr1 and pfcrt polymorphisms in amodiaquine resistance. Except for pfmdr1 1246Y (prevalence, 5%), no P. falciparum allele predicted treatment outcome. Pfcrt 76T as well as pfmdr1 86Y, 86Y-184F-1246D, and 86Y-184Y-1246Y were positively selected in treatment failures, and pfmdr1 86N-184F-1246D negatively. The weak association of pfmdr1/pfcrt alleles with amodiaquine treatment outcome suggests further factors to be involved in the unsatisfactory low efficacy of the drug and limits the usefulness of these markers in this area. 
650 4 |a Amodiaquine 
650 4 |a Burkina Faso 
650 4 |a Drug resistance 
650 4 |a Malaria 
700 1 |a Coulibaly, Boubacar  |d 1964-  |e VerfasserIn  |0 (DE-588)129504432  |0 (DE-627)47064639X  |0 (DE-576)18838961X  |4 aut 
700 1 |a Meissner, Peter  |e VerfasserIn  |0 (DE-588)1075391628  |0 (DE-627)833263811  |0 (DE-576)443462135  |4 aut 
700 1 |a Petruschke, Inga  |d 1978-  |e VerfasserIn  |0 (DE-588)132554402  |0 (DE-627)523642881  |0 (DE-576)29922211X  |4 aut 
700 1 |a Müller, Olaf  |d 1954-  |e VerfasserIn  |0 (DE-588)143910698  |0 (DE-627)655906479  |0 (DE-576)339649453  |4 aut 
700 1 |a Mockenhaupt, Frank Peter  |d 1969-  |e VerfasserIn  |0 (DE-588)121187500  |0 (DE-627)081142250  |0 (DE-576)292576137  |4 aut 
773 0 8 |i Enthalten in  |t Acta tropica  |d Amsterdam [u.a.] : Elsevier, 1989  |g 114(2010), 1 vom: Apr., Seite 63-66  |h Online-Ressource  |w (DE-627)303614587  |w (DE-600)1495527-1  |w (DE-576)081925948  |x 1873-6254  |7 nnas  |a Selection of pfmdr1 and pfcrt alleles in amodiaquine treatment failure in north-western Burkina Faso 
773 1 8 |g volume:114  |g year:2010  |g number:1  |g month:04  |g pages:63-66  |g extent:4  |a Selection of pfmdr1 and pfcrt alleles in amodiaquine treatment failure in north-western Burkina Faso 
856 4 0 |u https://doi.org/10.1016/j.actatropica.2009.12.008  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u https://www.sciencedirect.com/science/article/pii/S0001706X10000021  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20230810 
993 |a Article 
994 |a 2010 
998 |g 143910698  |a Müller, Olaf  |m 143910698:Müller, Olaf  |d 910000  |d 912800  |d 50000  |e 910000PM143910698  |e 912800PM143910698  |e 50000PM143910698  |k 0/910000/  |k 1/910000/912800/  |k 0/50000/  |p 5 
998 |g 1075391628  |a Meissner, Peter  |m 1075391628:Meissner, Peter  |d 50000  |e 50000PM1075391628  |k 0/50000/  |p 3 
999 |a KXP-PPN185512937X  |e 4364690945 
BIB |a Y 
SER |a journal 
JSO |a {"origin":[{"dateIssuedDisp":"7 January 2010","dateIssuedKey":"2010"}],"note":["Gesehen am 10.08.2023"],"physDesc":[{"extent":"4 S."}],"relHost":[{"type":{"bibl":"periodical","media":"Online-Ressource"},"disp":"Selection of pfmdr1 and pfcrt alleles in amodiaquine treatment failure in north-western Burkina FasoActa tropica","language":["eng"],"title":[{"title":"Acta tropica","title_sort":"Acta tropica"}],"part":{"pages":"63-66","text":"114(2010), 1 vom: Apr., Seite 63-66","issue":"1","volume":"114","year":"2010","extent":"4"},"pubHistory":["Nachgewiesen 46.1989 -"],"id":{"zdb":["1495527-1"],"eki":["303614587"],"issn":["1873-6254"]},"recId":"303614587","physDesc":[{"extent":"Online-Ressource"}],"note":["Gesehen am 14.09.2020"],"origin":[{"dateIssuedKey":"1989","publisherPlace":"Amsterdam [u.a.]","dateIssuedDisp":"1989-","publisher":"Elsevier"}]}],"person":[{"family":"Danquah","given":"Ina","role":"aut","display":"Danquah, Ina"},{"given":"Boubacar","family":"Coulibaly","display":"Coulibaly, Boubacar","role":"aut"},{"family":"Meissner","given":"Peter","role":"aut","display":"Meissner, Peter"},{"role":"aut","display":"Petruschke, Inga","family":"Petruschke","given":"Inga"},{"family":"Müller","given":"Olaf","role":"aut","display":"Müller, Olaf"},{"given":"Frank Peter","family":"Mockenhaupt","display":"Mockenhaupt, Frank Peter","role":"aut"}],"title":[{"title_sort":"Selection of pfmdr1 and pfcrt alleles in amodiaquine treatment failure in north-western Burkina Faso","title":"Selection of pfmdr1 and pfcrt alleles in amodiaquine treatment failure in north-western Burkina Faso"}],"recId":"185512937X","language":["eng"],"name":{"displayForm":["Ina Danquah, Boubacar Coulibaly, Peter Meissner, Inga Petruschke, Olaf Müller, Frank P. Mockenhaupt"]},"type":{"bibl":"article-journal","media":"Online-Ressource"},"id":{"doi":["10.1016/j.actatropica.2009.12.008"],"eki":["185512937X"]}} 
SRT |a DANQUAHINASELECTIONO7201 

Ähnliche Einträge