Diabetic neuropathy is a generalized phenomenon with impact on hand functional performance and quality of life
Background and purpose Diabetic sensorimotor peripheral neuropathy is usually considered to affect predominantly the lower limbs (LL-N), whereas the impact of upper limb neuropathy (UL-N) on hand functional performance and quality of life (QoL) has not been evaluated systematically. This study aims...
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| Hauptverfasser: | , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
October 2022
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| In: |
European journal of neurology
Year: 2022, Jahrgang: 29, Heft: 10, Pages: 3081-3091 |
| ISSN: | 1468-1331 |
| DOI: | 10.1111/ene.15446 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1111/ene.15446 Verlag, kostenfrei, Volltext: http://onlinelibrary.wiley.com/doi/abs/10.1111/ene.15446 
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| Verfasserangaben: | Zoltan Kender, Jan B. Groener, Johann M.E. Jende, Felix T. Kurz, Thomas Fleming, Alba Sulaj, Sigrid Schuh-Hofer, Rolf-Detlef Treede, Martin Bendszus, Julia Szendroedi, Peter P. Nawroth, Stefan Kopf |
MARC
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| 245 | 1 | 0 | |a Diabetic neuropathy is a generalized phenomenon with impact on hand functional performance and quality of life |c Zoltan Kender, Jan B. Groener, Johann M.E. Jende, Felix T. Kurz, Thomas Fleming, Alba Sulaj, Sigrid Schuh-Hofer, Rolf-Detlef Treede, Martin Bendszus, Julia Szendroedi, Peter P. Nawroth, Stefan Kopf |
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| 520 | |a Background and purpose Diabetic sensorimotor peripheral neuropathy is usually considered to affect predominantly the lower limbs (LL-N), whereas the impact of upper limb neuropathy (UL-N) on hand functional performance and quality of life (QoL) has not been evaluated systematically. This study aims to investigate the prevalence and characteristics of UL-N and its functional and psychosocial consequences in type 2 diabetes. Methods Individuals with type 2 diabetes (n = 141) and an age- and sex-matched control group (n = 73) underwent comprehensive assessment of neuropathy, hand functional performance, and psychosocial status. Results The prevalence of UL-N was 30.5% in patients with diabetes and that of LL-N was 49.6%, with 25.5% exhibiting both. Patients with diabetes showed similar sensory phenotype regarding both large and small fiber functions in hands and feet. Patients with UL-N showed reduced manual dexterity, but normal hand grip force. Additionally, there was a correlation between reduced dexterity and sensory deficits. Patients with UL-N had reduced estimates of psychosocial health including health-related QoL compared to control subjects and patients without UL-N. UL-N correlated with the severity of LL-N, but not with duration of diabetes, glycemia, age, or sex. Conclusions This study points to a substantial prevalence of UL-N in type 2 diabetes. The sensory phenotype of patients with UL-N was similar to LL-N and was characterized by loss of sensory function. Our study demonstrated an association of UL-N with impaired manual dexterity and reduced health-related QoL. Thus, upper limb sensorimotor functions should be assessed early in patients with diabetes. | ||
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