http://www.loc.gov/mods/v3 http://www.loc.gov/standards/mods/v3/mods-3-2.xsd
trans-ancestral genomic architecture of glycemic traits
Glycemic traits are used to diagnose and monitor type 2 diabetes and cardiometabolic health. To date, most genetic studies of glycemic traits have focused on individuals of European ancestry. Here we aggregated genome-wide association studies comprising up to 281,416 individuals without diabetes (30% non-European ancestry) for whom fasting glucose, 2-h glucose after an oral glucose challenge, glycated hemoglobin and fasting insulin data were available. Trans-ancestry and single-ancestry meta-analyses identified 242 loci (99 novel; P < 5 × 10−8), 80% of which had no significant evidence of between-ancestry heterogeneity. Analyses restricted to individuals of European ancestry with equivalent sample size would have led to 24 fewer new loci. Compared with single-ancestry analyses, equivalent-sized trans-ancestry fine-mapping reduced the number of estimated variants in 99% credible sets by a median of 37.5%. Genomic-feature, gene-expression and gene-set analyses revealed distinct biological signatures for each trait, highlighting different underlying biological pathways. Our results increase our understanding of diabetes pathophysiology by using trans-ancestry studies for improved power and resolution.
Ji Chen, Cassandra N. Spracklen, Gaëlle Marenne, Arushi Varshney, Laura J. Corbin, Jian’an Luan, Sara M. Willems, Ying Wu, Xiaoshuai Zhang, Momoko Horikoshi, Thibaud S. Boutin, Reedik Mägi, Johannes Waage, Ruifang Li-Gao, Kei Hang Katie Chan, Jie Yao, Mila D. Anasanti, Audrey Y. Chu, Annique Claringbould, Jani Heikkinen, Jaeyoung Hong, Jouke-Jan Hottenga, Shaofeng Huo, Marika A. Kaakinen, Tin Louie, Winfried März, Hortensia Moreno-Macias, Anne Ndungu, Sarah C. Nelson, Ilja M. Nolte, Kari E. North, Chelsea K. Raulerson, Debashree Ray, Rebecca Rohde, Denis Rybin, Claudia Schurmann, Xueling Sim, Lorraine Southam, Isobel D. Stewart, Carol A. Wang, Yujie Wang, Peitao Wu, Weihua Zhang, Tarunveer S. Ahluwalia, Emil V. R. Appel, Lawrence F. Bielak, Jennifer A. Brody, Noël P. Burtt, Claudia P. Cabrera, Brian E. Cade, Jin Fang Chai, Xiaoran Chai, Li-Ching Chang, Chien-Hsiun Chen, Brian H. Chen, Kumaraswamy Naidu Chitrala, Yen-Feng Chiu, Hugoline G. de Haan, Graciela E. Delgado, Ayse Demirkan, Qing Duan, Jorgen Engmann, Segun A. Fatumo, Javier Gayán, Franco Giulianini, Jung Ho Gong, Stefan Gustafsson, Yang Hai, Fernando P. Hartwig, Jing He, Yoriko Heianza, Tao Huang, Alicia Huerta-Chagoya, Mi Yeong Hwang, Richard A. Jensen, Takahisa Kawaguchi, Katherine A. Kentistou, Young Jin Kim, Marcus E. Kleber, Ishminder K. Kooner, Shuiqing Lai, Leslie A. Lange, Carl D. Langefeld, Marie Lauzon, Man Li, Symen Ligthart, Jun Liu, Marie Loh, Jirong Long, Valeriya Lyssenko, Massimo Mangino, Carola Marzi, May E. Montasser, Abhishek Nag, Masahiro Nakatochi, Damia Noce, Raymond Noordam, Giorgio Pistis, Michael Preuss, Laura Raffield, Laura J. Rasmussen-Torvik, Stephen S. Rich, Neil R. Robertson, Rico Rueedi, Kathleen Ryan, Serena Sanna, Richa Saxena, Katharina E. Schraut, Bengt Sennblad, Kazuya Setoh, Albert V. Smith, Thomas Sparsø, Rona J. Strawbridge, Fumihiko Takeuchi, Jingyi Tan, Stella Trompet, Erik van den Akker, Peter J. van der Most, Niek Verweij, Mandy Vogel, Heming Wang, Chaolong Wang, Nan Wang, Helen R. Warren, Wanqing Wen, Tom Wilsgaard, Andrew Wong, Andrew R. Wood, Tian Xie, Mohammad Hadi Zafarmand, Jing-Hua Zhao, Wei Zhao, Najaf Amin, Zorayr Arzumanyan, Arne Astrup, Stephan J.L. Bakker, Damiano Baldassarre, Marian Beekman, Richard N. Bergman, Alain Bertoni, Matthias Blüher, Lori L. Bonnycastle, Stefan R. Bornstein, Donald W. Bowden, Qiuyin Cai, Archie Campbell, Harry Campbell, Yi Cheng Chang, Eco J.C. de Geus, Abbas Dehghan, Shufa Du, Gudny Eiriksdottir, Aliki Eleni Farmaki, Mattias Frånberg, Christian Fuchsberger, Yutang Gao, Anette P. Gjesing, Anuj Goel, Sohee Han, Catharina A. Hartman, Christian Herder, Andrew A. Hicks, Chang-Hsun Hsieh, Willa A. Hsueh, Sahoko Ichihara, Michiya Igase, M. Arfan Ikram, W. Craig Johnson, Marit E. Jørgensen, Peter K. Joshi, Rita R. Kalyani, Fouad R. Kandeel, Tomohiro Katsuya, Chiea Chuen Khor, Wieland Kiess, Ivana Kolcic, Teemu Kuulasmaa, Johanna Kuusisto, Kristi Läll, Kelvin Lam, Deborah A. Lawlor, Nanette R. Lee, Rozenn N. Lemaitre, Honglan Li, Shih-Yi Lin, Jaana Lindström, Allan Linneberg, Jianjun Liu, Carlos Lorenzo, Tatsuaki Matsubara, Fumihiko Matsuda, Geltrude Mingrone, Simon Mooijaart, Sanghoon Moon, Toru Nabika, Girish N. Nadkarni, Jerry L. Nadler, Mari Nelis, Matt J. Neville, Jill M. Norris, Yasumasa Ohyagi, Annette Peters, Patricia A. Peyser, Ozren Polasek, Qibin Qi, Dennis Raven, Dermot F. Reilly, Alex Reiner, Fernando Rivideneira, Kathryn Roll, Igor Rudan, Charumathi Sabanayagam, Kevin Sandow, Naveed Sattar, Annette Schürmann, Jinxiu Shi, Heather M. Stringham, Kent D. Taylor, Tanya M. Teslovich, Betina Thuesen, Paul R.H.J. Timmers, Elena Tremoli, Michael Y. Tsai, Andre Uitterlinden, Rob M. van Dam, Diana van Heemst, Astrid van Hylckama Vlieg, Jana V. van Vliet-Ostaptchouk, Jagadish Vangipurapu, Henrik Vestergaard, Tao Wang, Ko Willems van Dijk, Tatijana Zemunik, Gonçalo R. Abecasis, Linda S. Adair, Carlos Alberto Aguilar-Salinas, Marta E. Alarcón-Riquelme, Ping An, Larissa Aviles-Santa, Diane M. Becker, Lawrence J. Beilin, Sven Bergmann, Hans Bisgaard, Corri Black, Michael Boehnke, Eric Boerwinkle, Bernhard O. Böhm, Klaus Bønnelykke, D.I. Boomsma, Erwin P. Bottinger, Thomas A. Buchanan, Mickaël Canouil, Mark J. Caulfield, John C. Chambers, Daniel I. Chasman, Yii-Der Ida Chen, Ching-Yu Cheng, Francis S. Collins, Adolfo Correa, Francesco Cucca, H. Janaka de Silva, George Dedoussis, Sölve Elmståhl, Michele K. Evans, Ele Ferrannini, Luigi Ferrucci, Jose C. Florez, Paul W. Franks, Timothy M. Frayling, Philippe Froguel, Bruna Gigante, Mark O. Goodarzi, Penny Gordon-Larsen, Harald Grallert, Niels Grarup, Sameline Grimsgaard, Leif Groop, Vilmundur Gudnason, Xiuqing Guo, Anders Hamsten, Torben Hansen, Caroline Hayward, Susan R. Heckbert, Bernardo L. Horta, Wei Huang, Erik Ingelsson, Pankow S. James, Marjo-Ritta Jarvelin, Jost B. Jonas, J. Wouter Jukema, Pontiano Kaleebu, Robert Kaplan, Sharon L.R. Kardia, Norihiro Kato, Sirkka M. Keinanen-Kiukaanniemi, Bong-Jo Kim, Mika Kivimaki, Heikki A. Koistinen, Jaspal S. Kooner, Antje Körner, Peter Kovacs, Diana Kuh, Meena Kumari, Zoltan Kutalik, Markku Laakso, Timo A. Lakka, Lenore J. Launer, Karin Leander, Huaixing Li, Xu Lin, Lars Lind, Cecilia Lindgren, Simin Liu, Ruth J.F. Loos, Patrik K.E. Magnusson, Anubha Mahajan, Andres Metspalu, Dennis O. Mook-Kanamori, Trevor A. Mori, Patricia B. Munroe, Inger Njølstad, Jeffrey R. O’Connell, Albertine J. Oldehinkel, Ken K. Ong, Sandosh Padmanabhan, Colin N.A. Palmer, Nicholette D. Palmer, Oluf Pedersen, Craig E. Pennell, David J. Porteous, Peter P. Pramstaller, Michael A. Province, Bruce M. Psaty, Lu Qi, Leslie J. Raffel, Rainer Rauramaa, Susan Redline, Paul M. Ridker, Frits R. Rosendaal, Timo E. Saaristo, Manjinder Sandhu, Jouko Saramies, Neil Schneiderman, Peter Schwarz, Laura J. Scott, Elizabeth Selvin, Peter Sever, Xiao-ou Shu, P. Eline Slagboom, Kerrin S. Small, Blair H. Smith, Harold Snieder, Tamar Sofer, Thorkild I.A. Sørensen, Tim D. Spector, Alice Stanton, Claire J. Steves, Michael Stumvoll, Liang Sun, Yasuharu Tabara, E. Shyong Tai, Nicholas J. Timpson, Anke Tönjes, Jaakko Tuomilehto, Teresa Tusie, Matti Uusitupa, Pim van der Harst, Cornelia van Duijn, Veronique Vitart, Peter Vollenweider, Tanja G.M. Vrijkotte, Lynne E. Wagenknecht, Mark Walker, Ya X. Wang, Nick J. Wareham, Richard M. Watanabe, Hugh Watkins, Wen B. Wei, Ananda R. Wickremasinghe, Gonneke Willemsen, James F. Wilson, Tien-Yin Wong, Jer-Yuarn Wu, Anny H. Xiang, Lisa R. Yanek, Loïc Yengo, Mitsuhiro Yokota, Eleftheria Zeggini, Wei Zheng, Alan B. Zonderman, Jerome I. Rotter, Anna L. Gloyn, Mark I. McCarthy, Josée Dupuis, James B. Meigs, Robert A. Scott, Inga Prokopenko, Aaron Leong, Ching-Ti Liu, Stephen C.J. Parker, Karen L. Mohlke, Claudia Langenberg, Eleanor Wheeler, Andrew P. Morris and Inês Barroso
The trans-ancestral genomic architecture of glycemic traits
London : Macmillan Publishers Limited, part of Springer Nature, 1992