Thrombocytosis in children and adolescents: classification, diagnostic approach, and clinical management
Secondary thrombocytosis is a frequent secondary finding in childhood infection and inflammation. Primary hereditary thrombocytosis may be caused by germline mutations within the genes encoding key regulators of thrombopoiesis, i.e., thrombopoietin (THPO) and its receptor c-MPL (MPL) or the receptor...
Gespeichert in:
| Hauptverfasser: | , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
12 March 2021
|
| In: |
Annals of hematology
Year: 2021, Jahrgang: 100, Heft: 7, Pages: 1647-1665 |
| ISSN: | 1432-0584 |
| DOI: | 10.1007/s00277-021-04485-0 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1007/s00277-021-04485-0 Verlag, kostenfrei, Volltext: https://link.springer.com/10.1007/s00277-021-04485-0 
|
| Verfasserangaben: | Clemens Stockklausner, C.M. Duffert, H. Cario, R. Knöfler, W. Streif, A.E. Kulozik, on behalf of THROMKID-Plus Studiengruppe der Gesellschaft für Thrombose- und Hämostaseforschung (GTH) and of Gesellschaft für Pädiatrische Onkologie und Hämatologie (GPOH) |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1856217043 | ||
| 003 | DE-627 | ||
| 005 | 20240306115616.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230815s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s00277-021-04485-0 |2 doi | |
| 035 | |a (DE-627)1856217043 | ||
| 035 | |a (DE-599)KXP1856217043 | ||
| 035 | |a (OCoLC)1425064466 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Stockklausner, Clemens |d 1976- |e VerfasserIn |0 (DE-588)123997747 |0 (DE-627)706503155 |0 (DE-576)185367720 |4 aut | |
| 245 | 1 | 0 | |a Thrombocytosis in children and adolescents |b classification, diagnostic approach, and clinical management |c Clemens Stockklausner, C.M. Duffert, H. Cario, R. Knöfler, W. Streif, A.E. Kulozik, on behalf of THROMKID-Plus Studiengruppe der Gesellschaft für Thrombose- und Hämostaseforschung (GTH) and of Gesellschaft für Pädiatrische Onkologie und Hämatologie (GPOH) |
| 264 | 1 | |c 12 March 2021 | |
| 300 | |a 19 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 15.08.2023 | ||
| 520 | |a Secondary thrombocytosis is a frequent secondary finding in childhood infection and inflammation. Primary hereditary thrombocytosis may be caused by germline mutations within the genes encoding key regulators of thrombopoiesis, i.e., thrombopoietin (THPO) and its receptor c-MPL (MPL) or the receptor’s effector kinase Januskinase2 (JAK2). Furthermore, somatic mutations in JAK2, MPL, and in the gene-encoding calreticulin (CALR) have been described to act as driver mutations within the so-called Philadelphia-negative myeloproliferative neoplasms (MPNs), namely essential thrombocythemia (ET), polycythemia vera (PV), and primary myelofibrosis (PMF). Increasing knowledge on the molecular mechanisms and on the clinical complications of these diseases is reflected by the WHO diagnostic criteria and European LeukemiaNet (ELN) recommendations on the management of adult MPN. However, data on childhood thrombocytosis are rare, and no consensus guidelines for pediatric thrombocytosis exist. Current literature has highlighted differences in the epidemiology and molecular pathogenesis of childhood thrombocytosis as compared to adults. Furthermore, age-dependent complications and pharmacological specificities suggest that recommendations tailored to the pediatric population are necessary in clinical practice. Here we summarize literature on classification, diagnostics, and clinical management of childhood thrombocytosis. | ||
| 700 | 1 | |a Duffert, Christin |d 1987- |e VerfasserIn |0 (DE-588)1207342211 |0 (DE-627)1693614707 |4 aut | |
| 700 | 1 | |a Cario, Holger |d 1966- |e VerfasserIn |0 (DE-588)113798717 |0 (DE-627)593161912 |0 (DE-576)172587654 |4 aut | |
| 700 | 1 | |a Knöfler, Ralf |d 1963- |e VerfasserIn |0 (DE-588)172842026 |0 (DE-627)69777158X |0 (DE-576)133697800 |4 aut | |
| 700 | 1 | |a Streif, Werner |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kulozik, Andreas |d 1959- |e VerfasserIn |0 (DE-588)1025736567 |0 (DE-627)723892032 |0 (DE-576)167091638 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Annals of hematology |d Berlin : Springer, 1991 |g 100(2021), 7, Seite 1647-1665 |h Online-Ressource |w (DE-627)253389852 |w (DE-600)1458429-3 |w (DE-576)072283157 |x 1432-0584 |7 nnas |a Thrombocytosis in children and adolescents classification, diagnostic approach, and clinical management |
| 773 | 1 | 8 | |g volume:100 |g year:2021 |g number:7 |g pages:1647-1665 |g extent:19 |a Thrombocytosis in children and adolescents classification, diagnostic approach, and clinical management |
| 856 | 4 | 0 | |u https://doi.org/10.1007/s00277-021-04485-0 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://link.springer.com/10.1007/s00277-021-04485-0 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20230815 | ||
| 993 | |a Article | ||
| 994 | |a 2021 | ||
| 998 | |g 1025736567 |a Kulozik, Andreas |m 1025736567:Kulozik, Andreas |d 910000 |d 910500 |e 910000PK1025736567 |e 910500PK1025736567 |k 0/910000/ |k 1/910000/910500/ |p 6 |y j | ||
| 998 | |g 1207342211 |a Duffert, Christin |m 1207342211:Duffert, Christin |d 910000 |d 910500 |e 910000PD1207342211 |e 910500PD1207342211 |k 0/910000/ |k 1/910000/910500/ |p 2 | ||
| 998 | |g 123997747 |a Stockklausner, Clemens |m 123997747:Stockklausner, Clemens |d 50000 |e 50000PS123997747 |k 0/50000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1856217043 |e 4366362279 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"display":"Stockklausner, Clemens","family":"Stockklausner","given":"Clemens","role":"aut"},{"display":"Duffert, Christin","family":"Duffert","given":"Christin","role":"aut"},{"given":"Holger","role":"aut","family":"Cario","display":"Cario, Holger"},{"role":"aut","given":"Ralf","family":"Knöfler","display":"Knöfler, Ralf"},{"display":"Streif, Werner","family":"Streif","given":"Werner","role":"aut"},{"display":"Kulozik, Andreas","family":"Kulozik","given":"Andreas","role":"aut"}],"title":[{"title_sort":"Thrombocytosis in children and adolescents","title":"Thrombocytosis in children and adolescents","subtitle":"classification, diagnostic approach, and clinical management"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"language":["eng"],"physDesc":[{"extent":"19 S."}],"id":{"eki":["1856217043"],"doi":["10.1007/s00277-021-04485-0"]},"origin":[{"dateIssuedDisp":"12 March 2021","dateIssuedKey":"2021"}],"name":{"displayForm":["Clemens Stockklausner, C.M. Duffert, H. Cario, R. Knöfler, W. Streif, A.E. Kulozik, on behalf of THROMKID-Plus Studiengruppe der Gesellschaft für Thrombose- und Hämostaseforschung (GTH) and of Gesellschaft für Pädiatrische Onkologie und Hämatologie (GPOH)"]},"recId":"1856217043","note":["Gesehen am 15.08.2023"],"relHost":[{"titleAlt":[{"title":"Hematology"}],"note":["Gesehen am 24.04.2025","Fortsetzung der Druck-Ausgabe","Ungezählte Beil. ab 80.2001: Supplement"],"type":{"media":"Online-Ressource","bibl":"periodical"},"pubHistory":["62, 1 (Februrary 1991)-"],"physDesc":[{"extent":"Online-Ressource"}],"language":["eng"],"title":[{"title":"Annals of hematology","subtitle":"organ of: Gesellschaft für Thrombose- und Hämostaseforschung, DGHO, Deutsche Gesellschaft für Hämatologie und Onkologie e.V., ÖGHO, Österreichische Gesellschaft für Hämatologie und Onkologie","title_sort":"Annals of hematology"}],"recId":"253389852","disp":"Thrombocytosis in children and adolescents classification, diagnostic approach, and clinical managementAnnals of hematology","origin":[{"publisherPlace":"Berlin ; Heidelberg ; New York","publisher":"Springer","dateIssuedKey":"1991","dateIssuedDisp":"1991-"}],"id":{"issn":["1432-0584"],"zdb":["1458429-3"],"eki":["253389852"]},"part":{"text":"100(2021), 7, Seite 1647-1665","extent":"19","volume":"100","pages":"1647-1665","year":"2021","issue":"7"}}]} | ||
| SRT | |a STOCKKLAUSTHROMBOCYT1220 | ||