Systemic reprogramming of endothelial cell signaling in metastasis and Cachexia
Proliferating cancer cells secrete a multitude of factors impacting metabolism, interorgan communication, and tumor progression. The distribution of tumor-derived factors to distant organs occurs via the circulation, which provides an extensive reactive surface lined by endothelial cells. Primary tu...
Gespeichert in:
| Hauptverfasser: | , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
July 2023
|
| In: |
Physiology
Year: 2023, Jahrgang: 38, Heft: 4, Pages: 189-202 |
| ISSN: | 1548-9221 |
| DOI: | 10.1152/physiol.00001.2023 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1152/physiol.00001.2023 Verlag, kostenfrei, Volltext: https://journals.physiology.org/doi/full/10.1152/physiol.00001.2023 
|
| Verfasserangaben: | Stephanie F. Preuss, Denise Grieshober and Hellmut G. Augustin |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1856241211 | ||
| 003 | DE-627 | ||
| 005 | 20240307061519.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230815s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1152/physiol.00001.2023 |2 doi | |
| 035 | |a (DE-627)1856241211 | ||
| 035 | |a (DE-599)KXP1856241211 | ||
| 035 | |a (OCoLC)1425212916 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Preuss, Stephanie |d 1995- |e VerfasserIn |0 (DE-588)1246955679 |0 (DE-627)1780223226 |4 aut | |
| 245 | 1 | 0 | |a Systemic reprogramming of endothelial cell signaling in metastasis and Cachexia |c Stephanie F. Preuss, Denise Grieshober and Hellmut G. Augustin |
| 264 | 1 | |c July 2023 | |
| 300 | |a 14 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 15.08.2023 | ||
| 520 | |a Proliferating cancer cells secrete a multitude of factors impacting metabolism, interorgan communication, and tumor progression. The distribution of tumor-derived factors to distant organs occurs via the circulation, which provides an extensive reactive surface lined by endothelial cells. Primary tumor-derived proteins impact cancer progression by modulating endothelial cell activation at the (pre-)metastatic niche, which affects tumor cell dissemination as well as the outgrowth of seeded metastatic cells into overt tumors. In addition, new insight indicates that endothelial cell signaling contributes to metabolic symptoms of cancer, including cancer-associated cachexia, opening a new field of vascular metabolism research. This review addresses how tumor-derived factors systemically affect endothelial cell signaling and activation and impact distant organs as well as tumor progression. | ||
| 650 | 4 | |a angiocrine signaling | |
| 650 | 4 | |a cachexia | |
| 650 | 4 | |a metastasis | |
| 650 | 4 | |a systemic signaling | |
| 650 | 4 | |a vascular endothelium | |
| 700 | 1 | |a Grieshober, Denise |d 1996- |e VerfasserIn |0 (DE-588)1299343589 |0 (DE-627)1856241327 |4 aut | |
| 700 | 1 | |a Augustin, Hellmut |d 1959- |e VerfasserIn |0 (DE-588)102307737X |0 (DE-627)717361470 |0 (DE-576)171124766 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Physiology |d Stanford, Calif. : HighWire Press, 2004 |g 38(2023), 4 vom: Juli, Seite 189-202 |h Online-Ressource |w (DE-627)320448460 |w (DE-600)2005759-3 |w (DE-576)090888294 |x 1548-9221 |7 nnas |a Systemic reprogramming of endothelial cell signaling in metastasis and Cachexia |
| 773 | 1 | 8 | |g volume:38 |g year:2023 |g number:4 |g month:07 |g pages:189-202 |g extent:14 |a Systemic reprogramming of endothelial cell signaling in metastasis and Cachexia |
| 856 | 4 | 0 | |u https://doi.org/10.1152/physiol.00001.2023 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://journals.physiology.org/doi/full/10.1152/physiol.00001.2023 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20230815 | ||
| 993 | |a Article | ||
| 994 | |a 2023 | ||
| 998 | |g 102307737X |a Augustin, Hellmut |m 102307737X:Augustin, Hellmut |d 60000 |d 65000 |e 60000PA102307737X |e 65000PA102307737X |k 0/60000/ |k 1/60000/65000/ |p 3 |y j | ||
| 998 | |g 1299343589 |a Grieshober, Denise |m 1299343589:Grieshober, Denise |d 140000 |e 140000PG1299343589 |k 0/140000/ |p 2 | ||
| 998 | |g 1246955679 |a Preuss, Stephanie |m 1246955679:Preuss, Stephanie |d 140000 |e 140000PP1246955679 |k 0/140000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1856241211 |e 4366424215 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"display":"Preuss, Stephanie","roleDisplay":"VerfasserIn","role":"aut","family":"Preuss","given":"Stephanie"},{"role":"aut","display":"Grieshober, Denise","roleDisplay":"VerfasserIn","given":"Denise","family":"Grieshober"},{"family":"Augustin","given":"Hellmut","display":"Augustin, Hellmut","roleDisplay":"VerfasserIn","role":"aut"}],"title":[{"title":"Systemic reprogramming of endothelial cell signaling in metastasis and Cachexia","title_sort":"Systemic reprogramming of endothelial cell signaling in metastasis and Cachexia"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"note":["Gesehen am 15.08.2023"],"language":["eng"],"recId":"1856241211","name":{"displayForm":["Stephanie F. Preuss, Denise Grieshober and Hellmut G. Augustin"]},"origin":[{"dateIssuedKey":"2023","dateIssuedDisp":"July 2023"}],"id":{"eki":["1856241211"],"doi":["10.1152/physiol.00001.2023"]},"physDesc":[{"extent":"14 S."}],"relHost":[{"physDesc":[{"extent":"Online-Ressource"}],"id":{"issn":["1548-9221"],"zdb":["2005759-3"],"eki":["320448460"]},"origin":[{"publisherPlace":"Stanford, Calif.","dateIssuedKey":"2004","publisher":"HighWire Press","dateIssuedDisp":"2004-"}],"name":{"displayForm":["published jointly by The American Physiological Society and the International Union of Physiological Sciences"]},"part":{"year":"2023","pages":"189-202","issue":"4","text":"38(2023), 4 vom: Juli, Seite 189-202","volume":"38","extent":"14"},"pubHistory":["19.2004,4 -"],"language":["eng"],"recId":"320448460","disp":"Systemic reprogramming of endothelial cell signaling in metastasis and CachexiaPhysiology","note":["Gesehen am 27.03.2025"],"type":{"media":"Online-Ressource","bibl":"periodical"},"title":[{"title":"Physiology","title_sort":"Physiology"}]}]} | ||
| SRT | |a PREUSSSTEPSYSTEMICRE2023 | ||