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Immunocytochemical correlation of peptides and tyrosine hydroxylase in nerve fibres of the human parotid gland

The peptidergic innervation of parenchymal and vascular components in the human parotid gland was investigated by double-labelling fluorescence. Peptide immunoreactivity in nerve fibres was correlated with the presence of tyrosine hydroxylase (TH). By light microscopy, acinar innervation consisted o...

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Bibliographische Detailangaben
Hauptverfasser: Heym, Christine (VerfasserIn) , Webber, Richard (VerfasserIn) , Adler, Detlev (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 1994
In: Archives of oral biology
Year: 1994, Jahrgang: 39, Heft: 3, Pages: 213-221
ISSN:1879-1506
DOI:10.1016/0003-9969(94)90047-7
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/0003-9969(94)90047-7
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/0003996994900477
Volltext
Verfasserangaben:Christine Heym, Richard Webber, Detlef Adler
Beschreibung
Zusammenfassung:The peptidergic innervation of parenchymal and vascular components in the human parotid gland was investigated by double-labelling fluorescence. Peptide immunoreactivity in nerve fibres was correlated with the presence of tyrosine hydroxylase (TH). By light microscopy, acinar innervation consisted of fibres with the combinations neuropeptide Y (NPY)/TH and NPY/vasoactive intestinal polypeptide (VIP). Some fibres were solely NPY, TH or VIP immunoreactive. Rarely, substance P (SP)/calcitonin gene-related (CGRP)-immunolabelled fibres were associated with acini. Intercalated ducts were often approached by NPY/TH- and VIP-containing fibres. VIP innervation of excretory ducts was sparse. Intralobular and intralobar excretory ducts, in addition to NPY and TH, revealed CGRP and CGRP/SP innervation, whereas nerve fibres on interlobar excretory ducts very rarely contained NPY and none of the other mediators. Vascular innervation consisted of NPY/TH and SP/CGRP fibres; in a few fibres SP was colocalized with leu-enkephalin. Large arteries were encircled by some VIP-positive fibres. The findings suggest a specific participation of neuropeptides and of peptide combinations in the regulation of parotid exocrine function.
Beschreibung:Falsche Namensform: richtig Detlev Adler
Elektronische Reproduktion der Druck-Ausgabe 8. März 2004
Gesehen am 16.08.2023
Beschreibung:Online Resource
ISSN:1879-1506
DOI:10.1016/0003-9969(94)90047-7

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