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Memory B cell development elicited by mRNA booster vaccinations in the elderly

Despite mRNA vaccination, elderly individuals remain especially vulnerable to severe consequences of SARS-CoV-2 infection. Here, we compare the memory B cell responses in a cohort of elderly and younger individuals who received mRNA booster vaccinations. Plasma neutralizing potency and breadth were...

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Hauptverfasser: Wang, Zijun (VerfasserIn) , Mücksch, Frauke (VerfasserIn) , Raspe, Raphael (VerfasserIn) , Johannsen, Frederik (VerfasserIn) , Turroja, Martina (VerfasserIn) , Canis, Marie (VerfasserIn) , ElTanbouly, Mohamed A. (VerfasserIn) , Santos, Gabriela S. Silva (VerfasserIn) , Johnson, Brianna (VerfasserIn) , Baharani, Viren A. (VerfasserIn) , Patejak, Rachel (VerfasserIn) , Yao, Kai-Hui (VerfasserIn) , Chirco, Bennett J. (VerfasserIn) , Millard, Katrina G. (VerfasserIn) , Shimeliovich, Irina (VerfasserIn) , Gazumyan, Anna (VerfasserIn) , Oliveira, Thiago Y. (VerfasserIn) , Bieniasz, Paul D. (VerfasserIn) , Hatziioannou, Theodora (VerfasserIn) , Caskey, Marina (VerfasserIn) , Nussenzweig, Michel C. (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: June 27 2023
In: Journal of experimental medicine
Year: 2023, Jahrgang: 220, Heft: 9, Pages: 1-12
ISSN:1540-9538
DOI:10.1084/jem.20230668
Online-Zugang:Verlag, kostenfrei, Volltext: https://doi.org/10.1084/jem.20230668
Verlag, kostenfrei, Volltext: https://rupress.org/jem/article/220/9/e20230668/214193/Memory-B-cell-development-elicited-by-mRNA-booster
Volltext
Verfasserangaben:Zijun Wang, Frauke Muecksch, Raphael Raspe, Frederik Johannsen, Martina Turroja, Marie Canis, Mohamed A. ElTanbouly, Gabriela S. Silva Santos, Brianna Johnson, Viren A. Baharani, Rachel Patejak, Kai-Hui Yao, Bennett J. Chirco, Katrina G. Millard, Irina Shimeliovich, Anna Gazumyan, Thiago Y. Oliveira, Paul D. Bieniasz, Theodora Hatziioannou, Marina Caskey, and Michel C. Nussenzweig
Beschreibung
Zusammenfassung:Despite mRNA vaccination, elderly individuals remain especially vulnerable to severe consequences of SARS-CoV-2 infection. Here, we compare the memory B cell responses in a cohort of elderly and younger individuals who received mRNA booster vaccinations. Plasma neutralizing potency and breadth were similar between the two groups. By contrast, the absolute number of SARS-CoV-2-specific memory B cells was lower in the elderly. Antibody sequencing revealed that the SARS-CoV-2-specific elderly memory compartments were more clonal and less diverse. Notably, memory antibodies from the elderly preferentially targeted the ACE2-binding site on the RBD, while those from younger individuals targeted less accessible but more conserved epitopes. Nevertheless, individual memory antibodies elicited by booster vaccines in the elderly and younger individuals showed similar levels of neutralizing activity and breadth against SARS-CoV-2 variants. Thus, the relatively diminished protective effects of vaccination against serious disease in the elderly are associated with a smaller number of antigen-specific memory B cells that express altered antibody repertoires.
Beschreibung:Gesehen am 16.08.2023
Beschreibung:Online Resource
ISSN:1540-9538
DOI:10.1084/jem.20230668

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