Mdm2-SUMO1: is bigger better?
Covalent modification of the oncogene product Mdm2 by the ubiquitin-related protein SUMO1 protects it from ubiquitination and enhances its E3 ligase activity towards p53 in vitro. Disappearance of SUMO-modified Mdm2, which is observed upon radiation, may thus be a prerequisite for DNA-damage-induced...
Gespeichert in:
| Hauptverfasser: | , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
September 2000
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| In: |
Nature cell biology
Year: 2000, Jahrgang: 2, Heft: 9, Pages: E161-E163 |
| ISSN: | 1476-4679 |
| DOI: | 10.1038/35023639 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/35023639 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/ncb0900_E161 
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| Verfasserangaben: | Frauke Melchior and Ludger Hengst |
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| 520 | |a Covalent modification of the oncogene product Mdm2 by the ubiquitin-related protein SUMO1 protects it from ubiquitination and enhances its E3 ligase activity towards p53 in vitro. Disappearance of SUMO-modified Mdm2, which is observed upon radiation, may thus be a prerequisite for DNA-damage-induced accumulation of p53. | ||
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