Scorpionfish BPI is highly active against multiple drug-resistant Pseudomonas aeruginosa isolates from people with cystic fibrosis
Chronic pulmonary infection is a hallmark of cystic fibrosis (CF) and requires continuous antibiotic treatment. In this context, Pseudomonas aeruginosa (Pa) is of special concern since colonizing strains frequently acquire multiple drug resistance (MDR). Bactericidal/permeability-increasing protein...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2023
|
| In: |
eLife
Year: 2023, Jahrgang: 12, Pages: 1-16 |
| ISSN: | 2050-084X |
| DOI: | 10.7554/eLife.86369 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.7554/eLife.86369
|
| Verfasserangaben: | Jonas Maurice Holzinger, Martina Toelge, Maren Werner, Katharina Ursula Ederer, Heiko Ingo Siegmund, David Peterhoff, Stefan Helmut Blaas, Nicolas Gisch, Christoph Brochhausen, André Gessner, Sigrid Bülow |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1856534308 | ||
| 003 | DE-627 | ||
| 005 | 20240307060733.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230818s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.7554/eLife.86369 |2 doi | |
| 035 | |a (DE-627)1856534308 | ||
| 035 | |a (DE-599)KXP1856534308 | ||
| 035 | |a (OCoLC)1425212806 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Holzinger, Jonas |e VerfasserIn |0 (DE-588)1299593283 |0 (DE-627)1856534618 |4 aut | |
| 245 | 1 | 0 | |a Scorpionfish BPI is highly active against multiple drug-resistant Pseudomonas aeruginosa isolates from people with cystic fibrosis |c Jonas Maurice Holzinger, Martina Toelge, Maren Werner, Katharina Ursula Ederer, Heiko Ingo Siegmund, David Peterhoff, Stefan Helmut Blaas, Nicolas Gisch, Christoph Brochhausen, André Gessner, Sigrid Bülow |
| 264 | 1 | |c 2023 | |
| 300 | |b Illustrationen | ||
| 300 | |a 16 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 18.08.2023 | ||
| 518 | |a Veröffentlicht: 18. Juli 2023 | ||
| 520 | |a Chronic pulmonary infection is a hallmark of cystic fibrosis (CF) and requires continuous antibiotic treatment. In this context, Pseudomonas aeruginosa (Pa) is of special concern since colonizing strains frequently acquire multiple drug resistance (MDR). Bactericidal/permeability-increasing protein (BPI) is a neutrophil-derived, endogenous protein with high bactericidal potency against Gram-negative bacteria. However, a significant range of people with CF (PwCF) produce anti-neutrophil cytoplasmic antibodies against BPI (BPI-ANCA), thereby neutralizing its bactericidal function. In accordance with literature, we describe that 51.0% of a total of 39 PwCF expressed BPI-ANCA. Importantly, an orthologous protein to human BPI (huBPI) derived from the scorpionfish Sebastes schlegelii (scoBPI) completely escaped recognition by these autoantibodies. Moreover, scoBPI exhibited high anti-inflammatory potency towards Pa LPS and was bactericidal against MDR Pa derived from PwCF at nanomolar concentrations. In conclusion, our results highlight the potential of highly active orthologous proteins of huBPI in treatment of MDR Pa infections, especially in the presence of BPI-ANCA. | ||
| 650 | 4 | |a anti-neutrophil cytoplasmic antibodies | |
| 650 | 4 | |a bactericidal/permeability-increasing protein | |
| 650 | 4 | |a cystic fibrosis | |
| 650 | 4 | |a multiple drug resistance | |
| 650 | 4 | |a Pseudomonas aeruginosa | |
| 650 | 4 | |a scorpionfish | |
| 700 | 1 | |a Toelge, Martina |e VerfasserIn |4 aut | |
| 700 | 1 | |a Werner, Maren |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ederer, Katharina Ursula |e VerfasserIn |4 aut | |
| 700 | 1 | |a Siegmund, Heiko Ingo |e VerfasserIn |4 aut | |
| 700 | 1 | |a Peterhoff, David |e VerfasserIn |4 aut | |
| 700 | 1 | |a Blaas, Stefan Helmut |e VerfasserIn |4 aut | |
| 700 | 1 | |a Gisch, Nicolas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Brochhausen, Christoph |d 1969- |e VerfasserIn |0 (DE-588)123220963 |0 (DE-627)082421226 |0 (DE-576)293610843 |4 aut | |
| 700 | 1 | |a Gessner, André |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bülow, Sigrid |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t eLife |d Cambridge : eLife Sciences Publications, 2012 |g 12(2023), Artikel-ID e86369, Seite 1-16 |h Online-Ressource |w (DE-627)728518384 |w (DE-600)2687154-3 |w (DE-576)372567576 |x 2050-084X |7 nnas |a Scorpionfish BPI is highly active against multiple drug-resistant Pseudomonas aeruginosa isolates from people with cystic fibrosis |
| 773 | 1 | 8 | |g volume:12 |g year:2023 |g elocationid:e86369 |g pages:1-16 |g extent:16 |a Scorpionfish BPI is highly active against multiple drug-resistant Pseudomonas aeruginosa isolates from people with cystic fibrosis |
| 856 | 4 | 0 | |u https://doi.org/10.7554/eLife.86369 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20230818 | ||
| 993 | |a Article | ||
| 994 | |a 2023 | ||
| 998 | |g 123220963 |a Brochhausen, Christoph |m 123220963:Brochhausen, Christoph |d 60000 |e 60000PB123220963 |k 0/60000/ |p 9 | ||
| 999 | |a KXP-PPN1856534308 |e 4367512290 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"recId":"1856534308","id":{"doi":["10.7554/eLife.86369"],"eki":["1856534308"]},"name":{"displayForm":["Jonas Maurice Holzinger, Martina Toelge, Maren Werner, Katharina Ursula Ederer, Heiko Ingo Siegmund, David Peterhoff, Stefan Helmut Blaas, Nicolas Gisch, Christoph Brochhausen, André Gessner, Sigrid Bülow"]},"relHost":[{"origin":[{"dateIssuedKey":"2012","publisher":"eLife Sciences Publications","dateIssuedDisp":"2012-","publisherPlace":"Cambridge"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"pubHistory":["1.2012 -"],"title":[{"title":"eLife","title_sort":"eLife"}],"note":["Gesehen am 28.06.17"],"recId":"728518384","id":{"eki":["728518384"],"issn":["2050-084X"],"zdb":["2687154-3"]},"language":["eng"],"part":{"text":"12(2023), Artikel-ID e86369, Seite 1-16","year":"2023","extent":"16","pages":"1-16","volume":"12"},"disp":"Scorpionfish BPI is highly active against multiple drug-resistant Pseudomonas aeruginosa isolates from people with cystic fibrosiseLife","physDesc":[{"extent":"Online-Ressource"}],"titleAlt":[{"title":"eLife journal"}]}],"physDesc":[{"extent":"16 S.","noteIll":"Illustrationen"}],"language":["eng"],"person":[{"family":"Holzinger","given":"Jonas","display":"Holzinger, Jonas","role":"aut"},{"role":"aut","display":"Toelge, Martina","family":"Toelge","given":"Martina"},{"role":"aut","display":"Werner, Maren","family":"Werner","given":"Maren"},{"display":"Ederer, Katharina Ursula","family":"Ederer","given":"Katharina Ursula","role":"aut"},{"role":"aut","display":"Siegmund, Heiko Ingo","given":"Heiko Ingo","family":"Siegmund"},{"role":"aut","display":"Peterhoff, David","given":"David","family":"Peterhoff"},{"role":"aut","given":"Stefan Helmut","family":"Blaas","display":"Blaas, Stefan Helmut"},{"display":"Gisch, Nicolas","family":"Gisch","given":"Nicolas","role":"aut"},{"role":"aut","given":"Christoph","family":"Brochhausen","display":"Brochhausen, Christoph"},{"role":"aut","given":"André","family":"Gessner","display":"Gessner, André"},{"role":"aut","display":"Bülow, Sigrid","family":"Bülow","given":"Sigrid"}],"title":[{"title_sort":"Scorpionfish BPI is highly active against multiple drug-resistant Pseudomonas aeruginosa isolates from people with cystic fibrosis","title":"Scorpionfish BPI is highly active against multiple drug-resistant Pseudomonas aeruginosa isolates from people with cystic fibrosis"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"origin":[{"dateIssuedKey":"2023","dateIssuedDisp":"2023"}],"note":["Gesehen am 18.08.2023"]} | ||
| SRT | |a HOLZINGERJSCORPIONFI2023 | ||