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The first PET glimpse of a proton FLASH beam

We demonstrate the first ever recorded positron-emission tomography (PET) imaging and dosimetry of a FLASH proton beam at the Proton Center of the MD Anderson Cancer Center. Two scintillating LYSO crystal arrays, read out by silicon photomultipliers, were configured with a partial field of view of a...

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Main Authors: Abouzahr, Firas (Author) , Cesar, J. P. (Author) , Crespo, P. (Author) , Gajda, M. (Author) , Hu, Z. (Author) , Kaye, W. (Author) , Klein, K. (Author) , Kuo, A. S. (Author) , Majewski, S. (Author) , Mawlawi, O. (Author) , Morozov, A. (Author) , Ojha, A. (Author) , Poenisch, F. (Author) , Polf, J. C. (Author) , Proga, M. (Author) , Sahoo, N. (Author) , Seco, Joao (Author) , Takaoka, T. (Author) , Tavernier, S. (Author) , Titt, U. (Author) , Wang, X. (Author) , Zhu, X. R. (Author) , Lang, K. (Author)
Format: Article (Journal)
Language:English
Published: 7 June 2023
In: Physics in medicine and biology
Year: 2023, Volume: 68, Issue: 12, Pages: 1-16
ISSN:1361-6560
DOI:10.1088/1361-6560/acd29e
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1088/1361-6560/acd29e
Verlag, kostenfrei, Volltext: https://iopscience.iop.org/article/10.1088/1361-6560/acd29e
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Author Notes:F. Abouzahr, J.P. Cesar, P. Crespo, M. Gajda, Z. Hu, W. Kaye, K. Klein, A.S. Kuo, S. Majewski, O. Mawlawi, A. Morozov, A. Ojha, F. Poenisch, J.C. Polf, M. Proga, N. Sahoo, J. Seco, T. Takaoka, S. Tavernier, U. Titt, X. Wang, X.R. Zhu and K. Lang

MARC

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520 |a We demonstrate the first ever recorded positron-emission tomography (PET) imaging and dosimetry of a FLASH proton beam at the Proton Center of the MD Anderson Cancer Center. Two scintillating LYSO crystal arrays, read out by silicon photomultipliers, were configured with a partial field of view of a cylindrical poly-methyl methacrylate (PMMA) phantom irradiated by a FLASH proton beam. The proton beam had a kinetic energy of 75.8 MeV and an intensity of about 3.5 × 1010 protons that were extracted over 101.5 ms-long spills. The radiation environment was characterized by cadmium-zinc-telluride and plastic scintillator counters. Preliminary results indicate that the PET technology used in our tests can efficiently record FLASH beam events. The instrument yielded informative and quantitative imaging and dosimetry of beam-activated isotopes in a PMMA phantom, as supported by Monte Carlo simulations. These studies open a new PET modality that can lead to improved imaging and monitoring of FLASH proton therapy. 
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