Dual function miR-205 is positively associated with ER and negatively with five-year survival in breast cancer patients
Background - Precise molecular characterization of breast cancer, especially triple negative (TNBC) as the most lethal subtype, is needed to stratify patients for the individual treatment approach. MicroRNA-205 (miR-205) has tumor-suppressive and oncogenic functions across different cancers. Therefo...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
17 August 2022
|
| In: |
Pathology, research and practice
Year: 2022, Volume: 238, Pages: 1-8 |
| ISSN: | 1618-0631 |
| DOI: | 10.1016/j.prp.2022.154080 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.prp.2022.154080 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0344033822003247 
|
| Author Notes: | Nina Petrović, Lidija Todorović, Milica Nedeljković, Ana Božović, Zoran Bukumirić, Nasta Dedović Tanić, Snežana Jovanović-Ćupić, Ahmad Šami, Vesna Mandušić |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1856822877 | ||
| 003 | DE-627 | ||
| 005 | 20240329080419.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230821s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.prp.2022.154080 |2 doi | |
| 035 | |a (DE-627)1856822877 | ||
| 035 | |a (DE-599)KXP1856822877 | ||
| 035 | |a (OCoLC)1425216995 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Petrović, Nina |e VerfasserIn |0 (DE-588)129980456X |0 (DE-627)1856823873 |4 aut | |
| 245 | 1 | 0 | |a Dual function miR-205 is positively associated with ER and negatively with five-year survival in breast cancer patients |c Nina Petrović, Lidija Todorović, Milica Nedeljković, Ana Božović, Zoran Bukumirić, Nasta Dedović Tanić, Snežana Jovanović-Ćupić, Ahmad Šami, Vesna Mandušić |
| 264 | 1 | |c 17 August 2022 | |
| 300 | |a 8 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Online verfügbar: 17 August 2022, Artikelversion: 19 August 2022 | ||
| 500 | |a Gesehen am 21.08.2023 | ||
| 520 | |a Background - Precise molecular characterization of breast cancer, especially triple negative (TNBC) as the most lethal subtype, is needed to stratify patients for the individual treatment approach. MicroRNA-205 (miR-205) has tumor-suppressive and oncogenic functions across different cancers. Therefore, miR-205 might have a different role in TNBC and estrogen receptor (ER) positive BC. Our aim was to investigate how miR-205 expression is associated with ER/progesteron receptor status, clinical parameters, pathohistological characteristics of BC, and survival of patients - Methods - We determined miR-205 relative expressions in 73 primary breast tumors (50 TNBC and 23 ER+) by quantitative Real-time polymerase chain reaction (qPCR) and compared it to clinicopathological characteristics and outcome. - Results - The highest levels of miR-205 were in the ER+ /PR+ group, and the lowest in the TNBC group (p = 0.009). Significantly higher levels of miR-205 were also observed in the ER+ compared with the ER-negative group, regardless of the PR status (p = 0.002). Low miR-205 expression level was associated with prognostic stage III in TNBC samples (p = 0.049). Patients who received adjuvant chemotherapy had significantly lower levels of miR-205 (p = 0.016). Patients who received hormone therapy had significantly higher levels of miR-205 (p = 0.007). The low-miR-205 patients had significantly higher 5-year survival rates (p = 0.041). - Conclusion - The expression of miR-205 in BC is subtype-specific and high expression is associated with the ER+ tumors. The miR-205 expression might be a useful marker of TNBC progression. High miR-205 expression had a detrimental effect on BC patient outcome. Our results indicate that miR-205 might be utilized in clinical practice as a biomarker and an adjunct parameter for the selection of the most effective therapeutic modality. | ||
| 650 | 4 | |a Chemotherapy | |
| 650 | 4 | |a Estrogen receptor-positive breast cancer | |
| 650 | 4 | |a Hormone therapy | |
| 650 | 4 | |a MiR-205 | |
| 650 | 4 | |a Survival | |
| 650 | 4 | |a Triple-negative breast cancer | |
| 700 | 1 | |a Todorović, Lidija |e VerfasserIn |4 aut | |
| 700 | 1 | |a Nedeljković, Milica |e VerfasserIn |4 aut | |
| 700 | 1 | |a Božović, Ana |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bukumirić, Zoran |e VerfasserIn |4 aut | |
| 700 | 1 | |a Tanić, Nasta Dedović |e VerfasserIn |4 aut | |
| 700 | 1 | |a Jovanović-Ćupić, Snežana |e VerfasserIn |0 (DE-588)1231743735 |0 (DE-627)1755360223 |4 aut | |
| 700 | 1 | |a Šami, Ahmad |d 1987- |e VerfasserIn |0 (DE-588)1230516158 |0 (DE-627)1752986636 |4 aut | |
| 700 | 1 | |a Mandušić, Vesna |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Pathology, research and practice |d München : Elsevier, 1978 |g 238(2022) vom: Okt., Artikel-ID 154080, Seite 1-8 |h Online-Ressource |w (DE-627)325789517 |w (DE-600)2039756-2 |w (DE-576)094480672 |x 1618-0631 |7 nnas |a Dual function miR-205 is positively associated with ER and negatively with five-year survival in breast cancer patients |
| 773 | 1 | 8 | |g volume:238 |g year:2022 |g month:10 |g elocationid:154080 |g pages:1-8 |g extent:8 |a Dual function miR-205 is positively associated with ER and negatively with five-year survival in breast cancer patients |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.prp.2022.154080 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S0344033822003247 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20230821 | ||
| 993 | |a Article | ||
| 994 | |a 2022 | ||
| 998 | |g 1230516158 |a Šami, Ahmad |m 1230516158:Šami, Ahmad |d 60000 |d 63000 |e 60000PS1230516158 |e 63000PS1230516158 |k 0/60000/ |k 1/60000/63000/ |p 8 | ||
| 999 | |a KXP-PPN1856822877 |e 4368607228 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"id":{"doi":["10.1016/j.prp.2022.154080"],"eki":["1856822877"]},"relHost":[{"id":{"zdb":["2039756-2"],"issn":["1618-0631"],"eki":["325789517"]},"physDesc":[{"extent":"Online-Ressource"}],"pubHistory":["162.1978 -"],"recId":"325789517","note":["Gesehen am 23.01.2018"],"title":[{"title":"Pathology, research and practice","title_sort":"Pathology, research and practice"}],"origin":[{"publisherPlace":"München ; Jena","dateIssuedDisp":"1978-","dateIssuedKey":"1978","publisher":"Elsevier ; Urban & Fischer"}],"titleAlt":[{"title":"Pathology"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"part":{"extent":"8","volume":"238","year":"2022","pages":"1-8","text":"238(2022) vom: Okt., Artikel-ID 154080, Seite 1-8"},"language":["eng"],"disp":"Dual function miR-205 is positively associated with ER and negatively with five-year survival in breast cancer patientsPathology, research and practice"}],"physDesc":[{"extent":"8 S."}],"name":{"displayForm":["Nina Petrović, Lidija Todorović, Milica Nedeljković, Ana Božović, Zoran Bukumirić, Nasta Dedović Tanić, Snežana Jovanović-Ćupić, Ahmad Šami, Vesna Mandušić"]},"recId":"1856822877","title":[{"title_sort":"Dual function miR-205 is positively associated with ER and negatively with five-year survival in breast cancer patients","title":"Dual function miR-205 is positively associated with ER and negatively with five-year survival in breast cancer patients"}],"note":["Online verfügbar: 17 August 2022, Artikelversion: 19 August 2022","Gesehen am 21.08.2023"],"origin":[{"dateIssuedDisp":"17 August 2022","dateIssuedKey":"2022"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"language":["eng"],"person":[{"display":"Petrović, Nina","family":"Petrović","role":"aut","given":"Nina"},{"family":"Todorović","display":"Todorović, Lidija","given":"Lidija","role":"aut"},{"role":"aut","given":"Milica","display":"Nedeljković, Milica","family":"Nedeljković"},{"family":"Božović","display":"Božović, Ana","given":"Ana","role":"aut"},{"family":"Bukumirić","display":"Bukumirić, Zoran","given":"Zoran","role":"aut"},{"role":"aut","given":"Nasta Dedović","display":"Tanić, Nasta Dedović","family":"Tanić"},{"given":"Snežana","role":"aut","display":"Jovanović-Ćupić, Snežana","family":"Jovanović-Ćupić"},{"family":"Šami","display":"Šami, Ahmad","given":"Ahmad","role":"aut"},{"family":"Mandušić","display":"Mandušić, Vesna","role":"aut","given":"Vesna"}]} | ||
| SRT | |a PETROVICNIDUALFUNCTI1720 | ||