Exercise elevates serum brain-derived neurotrophic factor in partially remitted depression
Brain-derived neurotrophic factor (BDNF) is a pleiotropic cytokine implicated in the pathogenesis of major depressive disorder (MDD). In MDD, serum BDNF levels are attenuated. Healthy adults show BDNF elevation after exercise. To investigate activity-dependent BDNF elevation in MDD, thirty-seven par...
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| Hauptverfasser: | , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
3 June 2023
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| In: |
Psychiatry research
Year: 2023, Jahrgang: 326, Pages: 1-3 |
| ISSN: | 1872-7123 |
| DOI: | 10.1016/j.psychres.2023.115283 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.psychres.2023.115283 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0165178123002330 
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| Verfasserangaben: | Benedikt Alexander Kramer, Anna Jaehn, Thea Marianne Grützner, Natalie Sarah Hess, Amanda Bellanti, Lena Listunova, Rainer Hellweg, Matthias Weisbrod, Daniela Roesch Ely |
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| 520 | |a Brain-derived neurotrophic factor (BDNF) is a pleiotropic cytokine implicated in the pathogenesis of major depressive disorder (MDD). In MDD, serum BDNF levels are attenuated. Healthy adults show BDNF elevation after exercise. To investigate activity-dependent BDNF elevation in MDD, thirty-seven participants with partially remitted MDD were allocated to either a bout of strenuous or light activity. Serum was collected before and after the intervention. BDNF was measured using a highly sensitive and specific enzyme-linked immunosorbent assay. Significant BDNF elevation in the strenuous activity group emerged. This study confirms exercise-dependent serum BDNF elevation in MDD. Preregistration: German Clinical Trials Register (DRKS0001515). | ||
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