Cover Image

Plant virus-mediated induction of miR168 is associated with repression of ARGONAUTE1 accumulation

Virus infections induce the expression of ARGONAUTE1 (AGO1) mRNA and in parallel enhance the accumulation of miR168 (regulator of AGO1 mRNA). Here, we show that in virus-infected plants the enhanced expression of AGO1 mRNA is not accompanied by increased AGO1 protein accumulation. We also show that...

Full description

Saved in:
Bibliographic Details
Main Authors: Várallyay, Éva (Author) , Válóczi, Anna (Author) , Ágyi, Ákos (Author) , Burgyán, József (Author) , Havelda, Zoltán (Author)
Format: Article (Journal)
Language:English
Published: 7 September 2010
In: The EMBO journal
Year: 2010, Volume: 29, Issue: 20, Pages: 3507-3519
ISSN:1460-2075
DOI:10.1038/emboj.2010.215
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1038/emboj.2010.215
Verlag, lizenzpflichtig, Volltext: https://www.embopress.org/doi/full/10.1038/emboj.2010.215
Get full text
Author Notes:Éva Várallyay, Anna Válóczi, Ákos Ágyi, József Burgyán and Zoltán Havelda

MARC

LEADER 00000caa a2200000 c 4500
001 1858261473
003 DE-627
005 20240311125146.0
007 cr uuu---uuuuu
008 230830s2010 xx |||||o 00| ||eng c
024 7 |a 10.1038/emboj.2010.215  |2 doi 
035 |a (DE-627)1858261473 
035 |a (DE-599)KXP1858261473 
035 |a (OCoLC)1425874184 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 32  |2 sdnb 
100 1 |a Várallyay, Éva  |e VerfasserIn  |0 (DE-588)1300483644  |0 (DE-627)1858262321  |4 aut 
245 1 0 |a Plant virus-mediated induction of miR168 is associated with repression of ARGONAUTE1 accumulation  |c Éva Várallyay, Anna Válóczi, Ákos Ágyi, József Burgyán and Zoltán Havelda 
264 1 |c 7 September 2010 
300 |a 13 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 30.08.2023 
520 |a Virus infections induce the expression of ARGONAUTE1 (AGO1) mRNA and in parallel enhance the accumulation of miR168 (regulator of AGO1 mRNA). Here, we show that in virus-infected plants the enhanced expression of AGO1 mRNA is not accompanied by increased AGO1 protein accumulation. We also show that the induction of AGO1 mRNA level is a part of the host defence reaction, whereas the induction of miR168, which overlaps spatially with virus-occupied sectors, is mediated mainly by the Tombusvirus p19 RNA-silencing suppressor. The absence of p19 results in the elimination of miR168 induction and accompanied with the enhanced accumulation of AGO1 protein. In transient expression study, p19 mediates the induction of miR168 and the down-regulation of endogenous AGO1 level. P19 is not able to efficiently bind miR168 in virus-infected plants, indicating that this activity is uncoupled from the small RNA-binding capacity of p19. Our results imply that plant viruses can inhibit the translational capacity of AGO1 mRNA by modulating the endogenous miR168 level to alleviate the anti-viral function of AGO1 protein. 
650 4 |a AGO1 
650 4 |a host defence 
650 4 |a miR168 
650 4 |a plant virus 
650 4 |a RNA-silencing suppressor 
700 1 |a Válóczi, Anna  |e VerfasserIn  |0 (DE-588)1300482818  |0 (DE-627)1858260833  |4 aut 
700 1 |a Ágyi, Ákos  |e VerfasserIn  |4 aut 
700 1 |a Burgyán, József  |e VerfasserIn  |4 aut 
700 1 |a Havelda, Zoltán  |e VerfasserIn  |4 aut 
773 0 8 |i Enthalten in  |a European Molecular Biology Organization  |t The EMBO journal  |d [London] : Nature Publishing Group UK, 1982  |g 29(2010), 20, Seite 3507-3519  |h Online-Ressource  |w (DE-627)266022529  |w (DE-600)1467419-1  |w (DE-576)075961377  |x 1460-2075  |7 nnas 
773 1 8 |g volume:29  |g year:2010  |g number:20  |g pages:3507-3519  |g extent:13  |a Plant virus-mediated induction of miR168 is associated with repression of ARGONAUTE1 accumulation 
856 4 0 |u https://doi.org/10.1038/emboj.2010.215  |x Resolving-System  |x Verlag  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u https://www.embopress.org/doi/full/10.1038/emboj.2010.215  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20230830 
993 |a Article 
994 |a 2010 
998 |g 1300482818  |a Válóczi, Anna  |m 1300482818:Válóczi, Anna  |d 140000  |e 140000PV1300482818  |k 0/140000/  |p 2 
999 |a KXP-PPN1858261473  |e 4371082637 
BIB |a Y 
SER |a journal 
JSO |a {"physDesc":[{"extent":"13 S."}],"relHost":[{"origin":[{"dateIssuedKey":"1982","publisher":"Nature Publishing Group UK ; EMBO Press ; Oxford Univ. Press ; Nature Publ. Group ; Wiley","dateIssuedDisp":"1982-","publisherPlace":"[London] ; Heidelberg ; Oxford [u.a.] ; London [u.a.] ; Hoboken, NJ [u.a.]"}],"id":{"doi":["10.1002/(ISSN)1460-2075"],"eki":["266022529"],"zdb":["1467419-1"],"issn":["1460-2075"]},"name":{"displayForm":["publ. for the European Molecular Biology Organization"]},"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title":"The EMBO journal","title_sort":"EMBO journal"}],"pubHistory":["1.1982 -"],"titleAlt":[{"title":"The EMBO journal online"}],"part":{"issue":"20","pages":"3507-3519","year":"2010","extent":"13","volume":"29","text":"29(2010), 20, Seite 3507-3519"},"disp":"European Molecular Biology OrganizationThe EMBO journal","note":["Gesehen am 18.02.2016","Fortsetzung der Druckausgabe"],"type":{"bibl":"periodical","media":"Online-Ressource"},"corporate":[{"role":"aut","display":"European Molecular Biology Organization","roleDisplay":"VerfasserIn"}],"language":["eng"],"recId":"266022529"}],"origin":[{"dateIssuedKey":"2010","dateIssuedDisp":"7 September 2010"}],"id":{"eki":["1858261473"],"doi":["10.1038/emboj.2010.215"]},"name":{"displayForm":["Éva Várallyay, Anna Válóczi, Ákos Ágyi, József Burgyán and Zoltán Havelda"]},"note":["Gesehen am 30.08.2023"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"recId":"1858261473","language":["eng"],"title":[{"title":"Plant virus-mediated induction of miR168 is associated with repression of ARGONAUTE1 accumulation","title_sort":"Plant virus-mediated induction of miR168 is associated with repression of ARGONAUTE1 accumulation"}],"person":[{"given":"Éva","family":"Várallyay","role":"aut","roleDisplay":"VerfasserIn","display":"Várallyay, Éva"},{"family":"Válóczi","given":"Anna","display":"Válóczi, Anna","roleDisplay":"VerfasserIn","role":"aut"},{"role":"aut","display":"Ágyi, Ákos","roleDisplay":"VerfasserIn","given":"Ákos","family":"Ágyi"},{"roleDisplay":"VerfasserIn","display":"Burgyán, József","role":"aut","family":"Burgyán","given":"József"},{"role":"aut","roleDisplay":"VerfasserIn","display":"Havelda, Zoltán","given":"Zoltán","family":"Havelda"}]} 
SRT |a VARALLYAYEPLANTVIRUS7201 

Similar Items