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Antithrombin, protein C, and protein S: genome and transcriptome-wide association studies identify 7 novel loci regulating plasma levels

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Background: Antithrombin, PC (protein C), and PS (protein S) are circulating natural anticoagulant proteins that regulate hemostasis and of which partial deficiencies are causes of venous thromboembolism. Previous genetic association studies involving antithrombin, PC, and PS were limited by modest...

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Main Authors: Ji, Yuekai (Author) , Temprano-Sagrera, Gerard (Author) , Holle, Lori A. (Author) , Bebo, Allison (Author) , Brody, Jennifer A. (Author) , Le, Ngoc-Quynh (Author) , Kangro, Kadri (Author) , Brown, Michael R. (Author) , Martinez-Perez, Angel (Author) , Sitlani, Colleen M. (Author) , Suchon, Pierre (Author) , Kleber, Marcus E. (Author) , Emmert, David B. (Author) , Bilge Ozel, Ayse (Author) , Dobson, Dre’Von A. (Author) , Tang, Weihong (Author) , Llobet, Dolors (Author) , Tracy, Russell P. (Author) , Deleuze, Jean-François (Author) , Delgado Gonzales de Kleber, Graciela (Author) , Gögele, Martin (Author) , Wiggins, Kerri L. (Author) , Souto, Juan Carlos (Author) , Pankow, James S. (Author) , Taylor, Kent D. (Author) , Trégouët, David-Alexandre (Author) , Moissl-Blanke, Angela P. (Author) , Fuchsberger, Christian (Author) , Rosendaal, Frits R. (Author) , Morrison, Alanna C. (Author) , Soria, Jose Manuel (Author) , Cushman, Mary (Author) , Morange, Pierre-Emmanuel (Author) , März, Winfried (Author) , Hicks, Andrew A. (Author) , Desch, Karl C. (Author) , Johnson, Andrew D. (Author) , de Vries, Paul S. (Author) , null, null (Author) , Wolberg, Alisa S. (Author) , Smith, Nicholas L. (Author) , Sabater-Lleal, Maria (Author)
Format: Article (Journal)
Language:English
Published: 27 Apr 2023
In: Arteriosclerosis, thrombosis, and vascular biology
Year: 2023, Volume: 43, Issue: 7, Pages: e254-e269
ISSN:1524-4636
DOI:10.1161/ATVBAHA.122.318213
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1161/ATVBAHA.122.318213
Verlag, lizenzpflichtig, Volltext: https://www.ahajournals.org/doi/10.1161/ATVBAHA.122.318213
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Author Notes:Yuekai Ji, Gerard Temprano-Sagrera, Lori A. Holle, Allison Bebo, Jennifer A. Brody, Ngoc-Quynh Le, Kadri Kangro, Michael R. Brown, Angel Martinez-Perez, Colleen M. Sitlani, Pierre Suchon, Marcus E. Kleber, David B. Emmert, Ayse Bilge Ozel, Dre’Von A. Dobson, Weihong Tang, Dolors Llobet, Russell P. Tracy, Jean-François Deleuze, Graciela E. Delgado, Martin Gögele, Kerri L. Wiggins, Juan Carlos Souto, James S. Pankow, Kent D. Taylor, David-Alexandre Trégouët, Angela P. Moissl, Christian Fuchsberger, Frits R. Rosendaal, Alanna C. Morrison, Jose Manuel Soria, Mary Cushman, Pierre-Emmanuel Morange, Winfried März, Andrew A. Hicks, Karl C. Desch, Andrew D. Johnson, Paul S. de Vries, CHARGE Consortium Hemostasis Working Group, INVENT Consortium, Alisa S. Wolberg, Nicholas L. Smith, Maria Sabater-Lleal
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Antithrombin, protein C and protein S: genome and transcriptome wide association studies identify 7 novel loci regulating plasma levels by Ji, Yuekai (Author) , Temprano-Sagrera, Gerard (Author) , Holle, Lori A. (Author) , Bebo, Allison (Author) , Brody, Jennifer (Author) , Le, Ngoc-Quynh (Author) , Brown, Michael R. (Author) , Martinez-Perez, Angel (Author) , Sitlani, Colleen M. (Author) , Suchon, Pierre (Author) , Kleber, Marcus E. (Author) , Emmert, David B. (Author) , Ozel, Ayse Bilge (Author) , Dobson, Dre’Von A. (Author) , Tang, Weihong (Author) , Llobet, Dolors (Author) , Tracy, Russell P. (Author) , Deleuze, Jean-François (Author) , Delgado Gonzales de Kleber, Graciela (Author) , Gögele, Martin (Author) , Wiggins, Kerri L. (Author) , Souto, Juan Carlos (Author) , Pankow, James S. (Author) , Taylor, Kent D. (Author) , Trégouët, David-Alexandre (Author) , Moissl-Blanke, Angela P. (Author) , Fuchsberger, Christian (Author) , Rosendaal, Frits R. (Author) , Morrison, Alanna C. (Author) , Soria, Jose Manuel (Author) , Cushman, Mary (Author) , Morange, Pierre-Emmanuel (Author) , März, Winfried (Author) , Hicks, Andrew A. (Author) , Desch, Karl C. (Author) , Johnson, Andrew D. (Author) , Vries, Paul S. de (Author) , Wolberg, Alisa S. (Author) , Smith, Nicholas L. (Author) , Sabater-Lleal, Maria (Author) ,


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