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PHD3 regulates differentiation, tumour growth and angiogenesis in pancreatic cancer

Tumour hypoxia activates hypoxia-inducible factor-1 (HIF-1) and indluences angiogenesis, cell survival and invasion. Prolyl hydroxylase-3 (PHD3) regulates degradation of HIF-1α. The effects of PHD3 in tumour growth are largely unknown.

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Bibliographic Details
Main Authors: Su, Yun (Author) , Loos, M. (Author) , Giese, Nathalia (Author) , Hines, O. J. (Author) , Diebold, I. (Author) , Görlach, A. (Author) , Metzen, E. (Author) , Pastorekova, S. (Author) , Friess, H. (Author) , Büchler, P. (Author)
Format: Article (Journal)
Language:English
Published: 26 October 2010
In: British journal of cancer
Year: 2010, Volume: 103, Issue: 10, Pages: 1571-1579
ISSN:1532-1827
DOI:10.1038/sj.bjc.6605936
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/sj.bjc.6605936
Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/6605936
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Author Notes:Y Su, M Loos, N Giese, OJ Hines, I Diebold, A Görlach, E Metzen, S Pastorekova, H Friess and P Büchler
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Summary:Tumour hypoxia activates hypoxia-inducible factor-1 (HIF-1) and indluences angiogenesis, cell survival and invasion. Prolyl hydroxylase-3 (PHD3) regulates degradation of HIF-1α. The effects of PHD3 in tumour growth are largely unknown.
Item Description:Gesehen am 04.09.2023
Physical Description:Online Resource
ISSN:1532-1827
DOI:10.1038/sj.bjc.6605936

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