PHD3 regulates differentiation, tumour growth and angiogenesis in pancreatic cancer
Tumour hypoxia activates hypoxia-inducible factor-1 (HIF-1) and indluences angiogenesis, cell survival and invasion. Prolyl hydroxylase-3 (PHD3) regulates degradation of HIF-1α. The effects of PHD3 in tumour growth are largely unknown.
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| Hauptverfasser: | , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
26 October 2010
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| In: |
British journal of cancer
Year: 2010, Jahrgang: 103, Heft: 10, Pages: 1571-1579 |
| ISSN: | 1532-1827 |
| DOI: | 10.1038/sj.bjc.6605936 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/sj.bjc.6605936 Verlag, lizenzpflichtig, Volltext: https://www.nature.com/articles/6605936 |
| Verfasserangaben: | Y Su, M Loos, N Giese, OJ Hines, I Diebold, A Görlach, E Metzen, S Pastorekova, H Friess and P Büchler |
| Zusammenfassung: | Tumour hypoxia activates hypoxia-inducible factor-1 (HIF-1) and indluences angiogenesis, cell survival and invasion. Prolyl hydroxylase-3 (PHD3) regulates degradation of HIF-1α. The effects of PHD3 in tumour growth are largely unknown. |
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| Beschreibung: | Gesehen am 04.09.2023 |
| Beschreibung: | Online Resource |
| ISSN: | 1532-1827 |
| DOI: | 10.1038/sj.bjc.6605936 |