Buchumschlag

Nickel (Ni) allergic patients with complications to Ni containing joint replacement show preferential IL-17 type reactivity to Ni

Background: Some nickel (Ni) allergic patients develop complications following Ni-containing arthroplasty. In the peri-implant tissue of such patients, we had observed lymphocyte dominated inflammation together with IFN-γ and IL-17 expression. Objectives: To determine whether Ni stimulation of perip...

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Hauptverfasser: Summer, Burkhard (VerfasserIn) , Korntheuer, Carina (VerfasserIn) , Mazoochian, Farhad (VerfasserIn) , Rau, Christoph (VerfasserIn) , Thomsen, Marc N. (VerfasserIn) , Banke, Ingo (VerfasserIn) , Gollwitzer, Hans (VerfasserIn) , Dietrich, Karin-Almut (VerfasserIn) , Mayer-Wagner, Susanne (VerfasserIn) , Ruzicka, Thomas (VerfasserIn) , Thomas, Peter (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: 14 June 2010
In: Contact dermatitis
Year: 2010, Jahrgang: 63, Heft: 1, Pages: 15-22
ISSN:1600-0536
DOI:10.1111/j.1600-0536.2010.01744.x
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1111/j.1600-0536.2010.01744.x
Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1111/j.1600-0536.2010.01744.x
Volltext
Verfasserangaben:Burkhard Summer, Carina Paul, Farhad Mazoochian, Christoph Rau, Marc Thomsen, Ingo Banke, Hans Gollwitzer, Karin-Almut Dietrich, Susanne Mayer-Wagner, Thomas Ruzicka and Peter Thomas
Beschreibung
Zusammenfassung:Background: Some nickel (Ni) allergic patients develop complications following Ni-containing arthroplasty. In the peri-implant tissue of such patients, we had observed lymphocyte dominated inflammation together with IFN-γ and IL-17 expression. Objectives: To determine whether Ni stimulation of peripheral blood mononuclear cells (PBMCs) of such patients would lead to a different cytokine pattern as compared to Ni-allergic patients with symptom-free arthroplasty. Patients and Methods: Based on history and patch testing in 15 Ni-allergic patients (five without implant, five with symptom-free arthroplasty, five with complicated arthroplasty) and five non-allergic individuals, lymphocyte transformation test (LTT) was performed using PBMC. In parallel in vitro cytokine response to Ni was assessed by real-time reverse transcriptase-polymerase chain reaction (RT-PCR). Results: All 15 Ni-allergic individuals showed enhanced LTT reactivity to Ni (mean SI = 8.42 ± 1.8) compared to the non-allergic control group. Predominant IFN-γ expression to Ni was found both in the five allergic patients without arthroplasty and also in the five allergic, symptom-free arthroplasty patients. In contrast, in the five Ni-allergic patients with arthroplasty-linked complications a predominant, significant IL-17 expression to Ni was seen but not in patients with symptom-free arthroplasty. Conclusions: The predominant IL-17 type response to Ni may characterize a subgroup of Ni-allergic patients prone to develop lymphocytic peri-implant hyper-reactivity.
Beschreibung:Gesehen am 06.09.2023
Beschreibung:Online Resource
ISSN:1600-0536
DOI:10.1111/j.1600-0536.2010.01744.x

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