Oxygen therapy reduces secondary hemorrhage after thrombolysis in thromboembolic cerebral ischemia
Hyperbaric oxygen (HBO) and normobaric hyperoxia (NBO) protect the brain parenchyma and the cerebral microcirculation against ischemia. We studied their effect on secondary hemorrhage after thrombolysis in two thromboembolic middle cerebral artery occlusion (MCAO) (tMCAO) models. Beginning 60 minute...
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
April 28, 2010
|
| In: |
Journal of cerebral blood flow & metabolism
Year: 2010, Jahrgang: 30, Heft: 9, Pages: 1651-1660 |
| ISSN: | 1559-7016 |
| DOI: | 10.1038/jcbfm.2010.50 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1038/jcbfm.2010.50
|
| Verfasserangaben: | Li Sun, Wei Zhou, Christian Mueller, Clemens Sommer, Sabine Heiland, Alexander T Bauer, Hugo H Marti, and Roland Veltkamp |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1858858259 | ||
| 003 | DE-627 | ||
| 005 | 20240311124615.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230906s2010 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/jcbfm.2010.50 |2 doi | |
| 035 | |a (DE-627)1858858259 | ||
| 035 | |a (DE-599)KXP1858858259 | ||
| 035 | |a (OCoLC)1425873803 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Sun, Li |e VerfasserIn |0 (DE-588)103638506X |0 (DE-627)749935510 |0 (DE-576)383896762 |4 aut | |
| 245 | 1 | 0 | |a Oxygen therapy reduces secondary hemorrhage after thrombolysis in thromboembolic cerebral ischemia |c Li Sun, Wei Zhou, Christian Mueller, Clemens Sommer, Sabine Heiland, Alexander T Bauer, Hugo H Marti, and Roland Veltkamp |
| 264 | 1 | |c April 28, 2010 | |
| 300 | |a 10 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 06.09.2023 | ||
| 520 | |a Hyperbaric oxygen (HBO) and normobaric hyperoxia (NBO) protect the brain parenchyma and the cerebral microcirculation against ischemia. We studied their effect on secondary hemorrhage after thrombolysis in two thromboembolic middle cerebral artery occlusion (MCAO) (tMCAO) models. Beginning 60 minutes after tMCAO with either thrombin-induced thromboemboli (TT) or calcium-induced thromboemboli (CT), spontaneously hypertensive rats (n=96) breathed either air, 100% O2 (NBO), or 100% O2 at 3 bar (HBO) for 1 hour. Immediately thereafter, recombinant tissue plasminogen activator (rt-PA, 9 mg/kg) was injected. Although significant reperfusion was observed after thrombolysis in TT-tMCAO, vascular occlusion persisted in CT-tMCAO. In TT-tMCAO, NBO and HBO significantly reduced diffusion-weighted imaging-magnetic resonance imaging (MRI) lesion volume and postischemic blood-brain barrier (BBB) permeability on postcontrast T1-weighted images. NBO and, significantly more potently, HBO reduced macroscopic hemorrhage on T2* MRI and on corresponding postmortem cryosections. Oxygen therapy lowered hemoglobin content and attenuated activation of matrix metalloproteinases in the ischemic hemisphere. In contrast, NBO and HBO failed to reduce infarct size in CT but both decreased BBB damage and microscopic hemorrhagic transformation. Only HBO reduced hemoglobin extravasation in the ischemic hemisphere. In conclusion, NBO and HBO decrease infarct size after thromboembolic ischemia only if recanalization is successful. As NBO and HBO also reduce postthrombolytic intracerebral hemorrhage, combining the two with thrombolysis seems promising. | ||
| 700 | 1 | |a Zhou, Wei |e VerfasserIn |0 (DE-588)1215661916 |0 (DE-627)1726758028 |4 aut | |
| 700 | 1 | |a Müller, Christian |e VerfasserIn |4 aut | |
| 700 | 1 | |a Sommer, Clemens |d 1964- |e VerfasserIn |0 (DE-588)1070862185 |0 (DE-627)824644514 |0 (DE-576)432763996 |4 aut | |
| 700 | 1 | |a Heiland, Sabine |e VerfasserIn |0 (DE-588)106732626X |0 (DE-627)818624450 |0 (DE-576)426561368 |4 aut | |
| 700 | 1 | |a Bauer, Alexander T. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Marti, Hugo |e VerfasserIn |0 (DE-588)1137018356 |0 (DE-627)893957208 |0 (DE-576)491045468 |4 aut | |
| 700 | 1 | |a Veltkamp, Roland |d 1966- |e VerfasserIn |0 (DE-588)172858453 |0 (DE-627)697787567 |0 (DE-576)133713997 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Journal of cerebral blood flow & metabolism |d Thousands Oaks, Calif. : Sage, 1981 |g 30(2010), 9 vom: Sept., Seite 1651-1660 |h Online-Ressource |w (DE-627)325700990 |w (DE-600)2039456-1 |w (DE-576)094480664 |x 1559-7016 |7 nnas |a Oxygen therapy reduces secondary hemorrhage after thrombolysis in thromboembolic cerebral ischemia |
| 773 | 1 | 8 | |g volume:30 |g year:2010 |g number:9 |g month:09 |g pages:1651-1660 |g extent:10 |a Oxygen therapy reduces secondary hemorrhage after thrombolysis in thromboembolic cerebral ischemia |
| 856 | 4 | 0 | |u https://doi.org/10.1038/jcbfm.2010.50 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20230906 | ||
| 993 | |a Article | ||
| 994 | |a 2010 | ||
| 998 | |g 172858453 |a Veltkamp, Roland |m 172858453:Veltkamp, Roland |d 910000 |d 911100 |d 50000 |e 910000PV172858453 |e 911100PV172858453 |e 50000PV172858453 |k 0/910000/ |k 1/910000/911100/ |k 0/50000/ |p 8 |y j | ||
| 998 | |g 1137018356 |a Marti, Hugo |m 1137018356:Marti, Hugo |d 50000 |d 53200 |e 50000PM1137018356 |e 53200PM1137018356 |k 0/50000/ |k 1/50000/53200/ |p 7 | ||
| 998 | |g 106732626X |a Heiland, Sabine |m 106732626X:Heiland, Sabine |d 910000 |d 911100 |e 910000PH106732626X |e 911100PH106732626X |k 0/910000/ |k 1/910000/911100/ |p 5 | ||
| 998 | |g 1070862185 |a Sommer, Clemens |m 1070862185:Sommer, Clemens |p 4 | ||
| 998 | |g 1215661916 |a Zhou, Wei |m 1215661916:Zhou, Wei |d 910000 |d 911100 |e 910000PZ1215661916 |e 911100PZ1215661916 |k 0/910000/ |k 1/910000/911100/ |p 2 | ||
| 998 | |g 103638506X |a Sun, Li |m 103638506X:Sun, Li |d 910000 |d 911100 |e 910000PS103638506X |e 911100PS103638506X |k 0/910000/ |k 1/910000/911100/ |p 1 |x j | ||
| 999 | |a KXP-PPN1858858259 |e 437308548X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedKey":"2010","dateIssuedDisp":"April 28, 2010"}],"note":["Gesehen am 06.09.2023"],"physDesc":[{"extent":"10 S."}],"relHost":[{"recId":"325700990","id":{"issn":["1559-7016"],"eki":["325700990"],"zdb":["2039456-1"]},"pubHistory":["1.1981 -"],"origin":[{"publisherPlace":"Thousands Oaks, Calif. ; London ; Philadelphia, Pa. ; Cambridge, Mass.","dateIssuedKey":"1981","publisher":"Sage ; Lippincott, Williams & Wilkins ; Nature Publ. Group","dateIssuedDisp":"1981-"}],"note":["Gesehen am 19. Juni 2017"],"physDesc":[{"extent":"Online-Ressource"}],"disp":"Oxygen therapy reduces secondary hemorrhage after thrombolysis in thromboembolic cerebral ischemiaJournal of cerebral blood flow & metabolism","titleAlt":[{"title":"JCBFM"},{"title":"Journal of cerebral blood flow and metabolism"}],"type":{"bibl":"periodical","media":"Online-Ressource"},"language":["eng"],"corporate":[{"display":"International Society of Cerebral Blood Flow and Metabolism","role":"isb"}],"part":{"year":"2010","volume":"30","extent":"10","text":"30(2010), 9 vom: Sept., Seite 1651-1660","pages":"1651-1660","issue":"9"},"title":[{"title":"Journal of cerebral blood flow & metabolism","title_sort":"Journal of cerebral blood flow & metabolism","subtitle":"JCBFM ; official journal of the International Society of Cerebral Blood Flow and Metabolism"}]}],"person":[{"display":"Sun, Li","role":"aut","given":"Li","family":"Sun"},{"display":"Zhou, Wei","role":"aut","given":"Wei","family":"Zhou"},{"display":"Müller, Christian","role":"aut","family":"Müller","given":"Christian"},{"display":"Sommer, Clemens","role":"aut","family":"Sommer","given":"Clemens"},{"family":"Heiland","given":"Sabine","role":"aut","display":"Heiland, Sabine"},{"family":"Bauer","given":"Alexander T.","role":"aut","display":"Bauer, Alexander T."},{"role":"aut","display":"Marti, Hugo","family":"Marti","given":"Hugo"},{"given":"Roland","family":"Veltkamp","role":"aut","display":"Veltkamp, Roland"}],"title":[{"title_sort":"Oxygen therapy reduces secondary hemorrhage after thrombolysis in thromboembolic cerebral ischemia","title":"Oxygen therapy reduces secondary hemorrhage after thrombolysis in thromboembolic cerebral ischemia"}],"recId":"1858858259","name":{"displayForm":["Li Sun, Wei Zhou, Christian Mueller, Clemens Sommer, Sabine Heiland, Alexander T Bauer, Hugo H Marti, and Roland Veltkamp"]},"language":["eng"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"id":{"eki":["1858858259"],"doi":["10.1038/jcbfm.2010.50"]}} | ||
| SRT | |a SUNLIZHOUWOXYGENTHER2820 | ||