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SLA/LP/tRNP(Ser)Sec antigen in autoimmune hepatitis: identification of the native protein in human hepatic cell extract

A diagnostic subgroup of AIH type 1 is characterized by specific serum antibodies against soluble liver protein. The respective autoantigen was named SLA/LP/tRNP(Ser)Sec, after three homologous recombinant polypeptides were isolated from expression gene libraries. We analyzed human cultured liver ce...

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Main Authors: Volkmann, Martin (Author) , Luithle, Daniel (Author) , Zentgraf, Hanswalter (Author) , Schnölzer, Martina (Author) , Fiedler, Sabine (Author) , Heid, Hans (Author) , Schulze-Bergkamen, Andrea (Author) , Strassburg, Christian P. (Author) , Gehrke, Sven (Author) , Manns, Michael P. (Author)
Format: Article (Journal)
Language:English
Published: 2010
In: Journal of autoimmunity
Year: 2010, Volume: 34, Issue: 1, Pages: 59-65
ISSN:1095-9157
DOI:10.1016/j.jaut.2009.07.005
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jaut.2009.07.005
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0896841109000894
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Author Notes:Martin Volkmann, Daniel Luithle, Hanswalter Zentgraf, Martina Schnölzer, Sabine Fiedler, Hans Heid, Andrea Schulze-Bergkamen, Christian P. Strassburg, Sven G. Gehrke, Michael P. Manns
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Summary:A diagnostic subgroup of AIH type 1 is characterized by specific serum antibodies against soluble liver protein. The respective autoantigen was named SLA/LP/tRNP(Ser)Sec, after three homologous recombinant polypeptides were isolated from expression gene libraries. We analyzed human cultured liver cells for the human homologue of recombinant SLA/LP/tRNP(Ser)Sec by antigen purification. In addition, a monoclonal antibody was generated against recombinant SLA-p35, a truncated recombinant SLA-reactive polypeptide...
Item Description:Online veröffentlicht am 14. August 2009
Im Titel erscheint die Zeichenfolge "(Ser)Sec" hochgestellt
Gesehen am 12.09.2023
Physical Description:Online Resource
ISSN:1095-9157
DOI:10.1016/j.jaut.2009.07.005

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