SLA/LP/tRNP(Ser)Sec antigen in autoimmune hepatitis: identification of the native protein in human hepatic cell extract
A diagnostic subgroup of AIH type 1 is characterized by specific serum antibodies against soluble liver protein. The respective autoantigen was named SLA/LP/tRNP(Ser)Sec, after three homologous recombinant polypeptides were isolated from expression gene libraries. We analyzed human cultured liver ce...
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| Hauptverfasser: | , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2010
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| In: |
Journal of autoimmunity
Year: 2010, Jahrgang: 34, Heft: 1, Pages: 59-65 |
| ISSN: | 1095-9157 |
| DOI: | 10.1016/j.jaut.2009.07.005 |
| Online-Zugang: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jaut.2009.07.005 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0896841109000894 
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| Verfasserangaben: | Martin Volkmann, Daniel Luithle, Hanswalter Zentgraf, Martina Schnölzer, Sabine Fiedler, Hans Heid, Andrea Schulze-Bergkamen, Christian P. Strassburg, Sven G. Gehrke, Michael P. Manns |
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| 520 | |a A diagnostic subgroup of AIH type 1 is characterized by specific serum antibodies against soluble liver protein. The respective autoantigen was named SLA/LP/tRNP(Ser)Sec, after three homologous recombinant polypeptides were isolated from expression gene libraries. We analyzed human cultured liver cells for the human homologue of recombinant SLA/LP/tRNP(Ser)Sec by antigen purification. In addition, a monoclonal antibody was generated against recombinant SLA-p35, a truncated recombinant SLA-reactive polypeptide... | ||
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