Micronodular thymic carcinoma with lymphoid hyperplasia: relevance of immunohistochemistry with a small panel of antibodies for diagnosis: a RYTHMIC study
Micronodular thymic carcinoma with lymphoid hyperplasia (MNTCLH) is a rare form of thymic carcinoma. We present the experience of RYTHMIC, the French national network devoted to the treatment of thymic epithelial tumors through multidisciplinary tumor boards with a review of all tumors by pathologis...
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| Hauptverfasser: | , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
October 2021
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| In: |
Virchows Archiv
Year: 2021, Jahrgang: 479, Heft: 4, Pages: 741-746 |
| ISSN: | 1432-2307 |
| DOI: | 10.1007/s00428-021-03044-2 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00428-021-03044-2
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| Verfasserangaben: | Vincent Thomas de Montpreville, Audrey Mansuet-Lupo, Cécile Le Naoures, Lara Chalabreysse, Anne De Muret, Véronique Hofman, Isabelle Rouquette, Nicolas Piton, Romain Dubois, Jose Carlos Benitez, Nicolas Girard, Benjamin Besse, Alexander Marx, Thierry Jo Molina |
MARC
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| 245 | 1 | 0 | |a Micronodular thymic carcinoma with lymphoid hyperplasia: relevance of immunohistochemistry with a small panel of antibodies for diagnosis |b a RYTHMIC study |c Vincent Thomas de Montpreville, Audrey Mansuet-Lupo, Cécile Le Naoures, Lara Chalabreysse, Anne De Muret, Véronique Hofman, Isabelle Rouquette, Nicolas Piton, Romain Dubois, Jose Carlos Benitez, Nicolas Girard, Benjamin Besse, Alexander Marx, Thierry Jo Molina |
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| 520 | |a Micronodular thymic carcinoma with lymphoid hyperplasia (MNTCLH) is a rare form of thymic carcinoma. We present the experience of RYTHMIC, the French national network devoted to the treatment of thymic epithelial tumors through multidisciplinary tumor boards with a review of all tumors by pathologists for classification and staging. Six cases of MNTCLH were diagnosed during a review of 1007 thymic epithelial tumors. Histologically, epithelial cells with atypia and mitoses formed micronodules that were surrounded by an abundant lymphoid background with follicles. There was neither obvious fibro-inflammatory stroma nor necrosis. Spindle cells areas were common. Initial diagnosis was micronodular thymoma in two cases, cellular atypia being overlooked, eclipsed by the micronodular pattern. Immunohistochemistry with a panel of five antibodies showed that cytokeratins (AE1-AE3) and p63-positive epithelial cells also expressed CD5 and that there was no TdT-positive cells within the tumors. CD20 highlighted the lymphoid hyperplasia. Additionally epithelial cells also expressed CD117 and diffusely Glut 1. Twenty-seven micronodular thymomas with lymphoid stroma diagnosed during the same period did not show the CD5 and CD117 positivities seen in MNTCLH and contained TdT-positive lymphocytes. Three of the 6 patients with MNTCLH had adjuvant radiotherapy. Three patients with follow-up information were alive without recurrence at 38, 51, and 95 months. Our study shows that immunohistochemistry, such as that used in the RYTHMIC network with a small panel of antibodies, may easily help to confirm the correct diagnosis of MNTCLH, a rare and low-aggressive form of thymic carcinoma, and avoid the misdiagnosis of micronodular thymoma. | ||
| 650 | 4 | |a Immunohistochemistry | |
| 650 | 4 | |a Micronodular thymic carcinoma with lymphoid hyperplasia | |
| 650 | 4 | |a Thymic neoplasm | |
| 700 | 1 | |a Mansuet-Lupo, Audrey |e VerfasserIn |4 aut | |
| 700 | 1 | |a Le Naoures, Cécile |e VerfasserIn |4 aut | |
| 700 | 1 | |a Chalabreysse, Lara |e VerfasserIn |4 aut | |
| 700 | 1 | |a De Muret, Anne |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hofman, Véronique |e VerfasserIn |4 aut | |
| 700 | 1 | |a Rouquette, Isabelle |e VerfasserIn |4 aut | |
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| 700 | 1 | |a Dubois, Romain |e VerfasserIn |4 aut | |
| 700 | 1 | |a Benitez, Jose Carlos |e VerfasserIn |4 aut | |
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