Avoiding scar tissue formation of peripheral nerves with the help of an acellular collagen matrix

Extensive scar tissue formation after peripheral nerve injury or surgery is a common problem. To avoid perineural scarring, implanting a mechanical barrier protecting the nerve from inflammation processes in the perineural environment has shown promising results for functional recovery. This study i...

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Main Authors: Aman, Martin (Author) , Mayrhofer-Schmid, Maximilian (Author) , Schwarz, Daniel (Author) , Bendszus, Martin (Author) , Däschler, Simeon C. (Author) , Klemm, Tess (Author) , Kneser, Ulrich (Author) , Harhaus-Wähner, Leila (Author) , Böcker, Arne Hendrik (Author)
Format: Article (Journal)
Language:English
Published: August 4, 2023
In: PLOS ONE
Year: 2023, Volume: 18, Issue: 8, Pages: 1-16
ISSN:1932-6203
DOI:10.1371/journal.pone.0289677
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.1371/journal.pone.0289677
Verlag, kostenfrei, Volltext: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0289677
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Author Notes:Martin Aman, Maximilian Mayrhofer-Schmid, Daniel Schwarz, Martin Bendszus, Simeon C. Daeschler, Tess Klemm, Ulrich Kneser, Leila Harhaus, Arne H. Boecker
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Summary:Extensive scar tissue formation after peripheral nerve injury or surgery is a common problem. To avoid perineural scarring, implanting a mechanical barrier protecting the nerve from inflammation processes in the perineural environment has shown promising results for functional recovery. This study investigates the potential of an acellular collagen-elastin matrix wrapped around a peripheral nerve after induction of scar tissue formation.
Item Description:Gesehen am 19.12.2023
Physical Description:Online Resource
ISSN:1932-6203
DOI:10.1371/journal.pone.0289677