Functional ankle instability as a risk factor for osteoarthritis: using T2-mapping to analyze early cartilage degeneration in the ankle joint of young athletes
Objective - The aim of this study was to investigate, using T2-mapping, the impact of functional instability in the ankle joint on the development of early cartilage damage. - Methods - Ethical approval for this study was provided. Thirty-six volunteers from the university sports program were divide...
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| Hauptverfasser: | , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
October 2014
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| In: |
Osteoarthritis and cartilage
Year: 2014, Jahrgang: 22, Heft: 10, Pages: 1377-1385 |
| ISSN: | 1522-9653 |
| DOI: | 10.1016/j.joca.2014.04.029 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.joca.2014.04.029 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S106345841401067X 
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| Verfasserangaben: | T. Golditz, S. Steib, K. Pfeifer, M. Uder, K. Gelse, R. Janka, F.F. Hennig, G.H. Welsch |
| Zusammenfassung: | Objective - The aim of this study was to investigate, using T2-mapping, the impact of functional instability in the ankle joint on the development of early cartilage damage. - Methods - Ethical approval for this study was provided. Thirty-six volunteers from the university sports program were divided into three groups according to their ankle status: functional ankle instability (FAI, initial ankle sprain with residual instability); ankle sprain Copers (initial sprain, without residual instability); and controls (without a history of ankle injuries). Quantitative T2-mapping magnetic resonance imaging (MRI) was performed at the beginning (‘early-unloading’) and at the end (‘late-unloading’) of the MR-examination, with a mean time span of 27 min. Zonal region-of-interest T2-mapping was performed on the talar and tibial cartilage in the deep and superficial layers. The inter-group comparisons of T2-values were analyzed using paired and unpaired t-tests. Statistical analysis of variance was performed. - Results - T2-values showed significant to highly significant differences in 11 of 12 regions throughout the groups. In early-unloading, the FAI-group showed a significant increase in quantitative T2-values in the medial, talar regions (P = 0.008, P = 0.027), whereas the Coper-group showed this enhancement in the central-lateral regions (P = 0.05). Especially the comparison of early-loading to late-unloading values revealed significantly decreasing T2-values over time laterally and significantly increasing T2-values medially in the FAI-group, which were not present in the Coper- or control-group. - Conclusion - Functional instability causes unbalanced loading in the ankle joint, resulting in cartilage alterations as assessed by quantitative T2-mapping. This approach can visualize and localize early cartilage abnormalities, possibly enabling specific treatment options to prevent osteoarthritis in young athletes. |
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| Beschreibung: | Gesehen am 15.09.2023 |
| Beschreibung: | Online Resource |
| ISSN: | 1522-9653 |
| DOI: | 10.1016/j.joca.2014.04.029 |