Molecular imaging of myocardial fibroblast activation in patients with advanced aortic stenosis before transcatheter aortic valve replacement: a pilot study
Using multimodal imaging, we investigated the extent and functional correlates of myocardial fibroblast activation in patients with aortic stenosis (AS) scheduled for transcatheter aortic valve replacement (TAVR). AS may cause myocardial fibrosis, which is associated with disease progression and may...
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| Hauptverfasser: | , , , , , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
August 1, 2023
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| In: |
Journal of nuclear medicine
Year: 2023, Jahrgang: 64, Heft: 8, Pages: 1279-1286 |
| ISSN: | 2159-662X |
| DOI: | 10.2967/jnumed.122.265147 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.2967/jnumed.122.265147 Verlag, lizenzpflichtig, Volltext: https://jnm.snmjournals.org/content/64/8/1279 
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| Verfasserangaben: | Johanna Diekmann, Jonas Neuser, Manuel Röhrich, Thorsten Derlin, Carolin Zwadlo, Tobias Koenig, Desiree Weiberg, Felix Jäckle, Tibor Kempf, Tobias L. Ross, Jochen Tillmanns, James T. Thackeray, Julian Widder, Uwe Haberkorn, Johann Bauersachs, and Frank M. Bengel |
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| 520 | |a Using multimodal imaging, we investigated the extent and functional correlates of myocardial fibroblast activation in patients with aortic stenosis (AS) scheduled for transcatheter aortic valve replacement (TAVR). AS may cause myocardial fibrosis, which is associated with disease progression and may limit response to TAVR. Novel radiopharmaceuticals identify upregulation of fibroblast activation protein (FAP) as a cellular substrate of cardiac profibrotic activity. | ||
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