Prognostic value of disease-free interval in colorectal cancer: Is it time?
Background - Previous studies have outlined that the onset of synchronous colorectal cancer (CRC) metastases is associated with poor overall survival (OS) compared to patients with metachronous disease. The aim of this study was to evaluate the association of disease-free interval with newly diagnos...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
26 September 2022
|
| In: |
European journal of surgical oncology
Year: 2022, Jahrgang: 48, Heft: 9, Pages: 2032-2038 |
| ISSN: | 1532-2157 |
| DOI: | 10.1016/j.ejso.2022.06.001 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ejso.2022.06.001 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0748798322004851 
|
| Verfasserangaben: | Emrullah Birgin, Fabian Doyon, Justin Burkert, Patrick Téoule, Erik Rasbach, Mohammad Rahbari, Christoph Reissfelder, Alexander Betzler, Nuh N. Rahbari |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1859820441 | ||
| 003 | DE-627 | ||
| 005 | 20240329080733.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230918s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.ejso.2022.06.001 |2 doi | |
| 035 | |a (DE-627)1859820441 | ||
| 035 | |a (DE-599)KXP1859820441 | ||
| 035 | |a (OCoLC)1425216729 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Birgin, Emrullah |d 1988- |e VerfasserIn |0 (DE-588)1140789880 |0 (DE-627)898681960 |0 (DE-576)494041625 |4 aut | |
| 245 | 1 | 0 | |a Prognostic value of disease-free interval in colorectal cancer |b Is it time? |c Emrullah Birgin, Fabian Doyon, Justin Burkert, Patrick Téoule, Erik Rasbach, Mohammad Rahbari, Christoph Reissfelder, Alexander Betzler, Nuh N. Rahbari |
| 264 | 1 | |c 26 September 2022 | |
| 300 | |a 7 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Online verfügbar: 3 June 2022, Artikelversion: 26 September 2022 | ||
| 500 | |a Gesehen am 18.09.2023 | ||
| 520 | |a Background - Previous studies have outlined that the onset of synchronous colorectal cancer (CRC) metastases is associated with poor overall survival (OS) compared to patients with metachronous disease. The aim of this study was to evaluate the association of disease-free interval with newly diagnosed CRC scheduled for primary tumor resection. - Methods - Patients who underwent primary CRC resection over an 18-year period were identified from a prospective database at a tertiary-care hospital. In this observational study, the cohort was stratified for the onset of metastases, i.e. synchronous, early-onset and late-onset metachronous disease. The OS was compared using Kaplan-Meier estimators and stratified Cox hazard regression analysis. - Results - Of 360 patients, 204 (57%) had synchronous, 61 (17%) had early metachronous, and 95 (26%) had late metachronous metastases, respectively. The onset of synchronous metastases was not associated with worse OS compared to early and late metachronous disease. ASA level > II (P = 0.011), right-sided compared to left-sided cancer (P = 0.032) or rectal cancer (P < 0.001), and high-grade tumors (P = 0.022) were identified as independent predictors of poor OS, whereas the only favorable prognostic factor was surgical resection of metastases (P = 0.047). Additionally, ASA level < III (P = 0.003) and low-grade tumors (P = 0.032) were found to predict resection of metastases. - Conclusion - Individual patients' and tumor characteristics rather than the timing of metastases are associated with OS in newly diagnosed CRC. These data support curative treatment strategies even in patients with synchronous metastases. | ||
| 650 | 4 | |a AJCC | |
| 650 | 4 | |a Colon cancer | |
| 650 | 4 | |a Oncology | |
| 650 | 4 | |a Rectal cancer | |
| 650 | 4 | |a UICC IV | |
| 700 | 1 | |a Doyon, Fabian |d 1981- |e VerfasserIn |0 (DE-588)1013792513 |0 (DE-627)664944507 |0 (DE-576)347744087 |4 aut | |
| 700 | 1 | |a Burkert, Justin Lukas |d 1996- |e VerfasserIn |0 (DE-588)1302783173 |0 (DE-627)1859820697 |4 aut | |
| 700 | 1 | |a Téoule, Patrick |d 1985- |e VerfasserIn |0 (DE-588)1071588109 |0 (DE-627)826067107 |0 (DE-576)433173521 |4 aut | |
| 700 | 1 | |a Rasbach, Erik |d 1992- |e VerfasserIn |0 (DE-588)1207323675 |0 (DE-627)1693581663 |4 aut | |
| 700 | 1 | |a Rahbari, Mohammad |e VerfasserIn |0 (DE-588)1192953541 |0 (DE-627)1671484282 |4 aut | |
| 700 | 1 | |a Reißfelder, Christoph |d 1975- |e VerfasserIn |0 (DE-588)1025566211 |0 (DE-627)722940297 |0 (DE-576)370516044 |4 aut | |
| 700 | 1 | |a Betzler, Alexander |d 1982- |e VerfasserIn |0 (DE-588)1036786110 |0 (DE-627)751692646 |0 (DE-576)386838089 |4 aut | |
| 700 | 1 | |a Rahbari, Nuh Nabi |d 1980- |e VerfasserIn |0 (DE-588)132519356 |0 (DE-627)523331908 |0 (DE-576)299198464 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t European journal of surgical oncology |d Burlington, Mass. : Harcourt, 1995 |g 48(2022), 9 vom: Sept., Seite 2032-2038 |h Online-Ressource |w (DE-627)320420361 |w (DE-600)2002481-2 |w (DE-576)103746862 |x 1532-2157 |7 nnas |a Prognostic value of disease-free interval in colorectal cancer Is it time? |
| 773 | 1 | 8 | |g volume:48 |g year:2022 |g number:9 |g month:09 |g pages:2032-2038 |g extent:7 |a Prognostic value of disease-free interval in colorectal cancer Is it time? |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.ejso.2022.06.001 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S0748798322004851 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20230918 | ||
| 993 | |a Article | ||
| 994 | |a 2022 | ||
| 998 | |g 132519356 |a Rahbari, Nuh Nabi |m 132519356:Rahbari, Nuh Nabi |d 60000 |d 61800 |e 60000PR132519356 |e 61800PR132519356 |k 0/60000/ |k 1/60000/61800/ |p 9 |y j | ||
| 998 | |g 1036786110 |a Betzler, Alexander |m 1036786110:Betzler, Alexander |d 60000 |d 61800 |e 60000PB1036786110 |e 61800PB1036786110 |k 0/60000/ |k 1/60000/61800/ |p 8 | ||
| 998 | |g 1025566211 |a Reißfelder, Christoph |m 1025566211:Reißfelder, Christoph |d 60000 |d 61800 |d 50000 |e 60000PR1025566211 |e 61800PR1025566211 |e 50000PR1025566211 |k 0/60000/ |k 1/60000/61800/ |k 0/50000/ |p 7 | ||
| 998 | |g 1192953541 |a Rahbari, Mohammad |m 1192953541:Rahbari, Mohammad |d 60000 |d 61800 |e 60000PR1192953541 |e 61800PR1192953541 |k 0/60000/ |k 1/60000/61800/ |p 6 | ||
| 998 | |g 1207323675 |a Rasbach, Erik |m 1207323675:Rasbach, Erik |d 60000 |d 61800 |e 60000PR1207323675 |e 61800PR1207323675 |k 0/60000/ |k 1/60000/61800/ |p 5 | ||
| 998 | |g 1071588109 |a Téoule, Patrick |m 1071588109:Téoule, Patrick |d 60000 |d 61800 |e 60000PT1071588109 |e 61800PT1071588109 |k 0/60000/ |k 1/60000/61800/ |p 4 | ||
| 998 | |g 1302783173 |a Burkert, Justin Lukas |m 1302783173:Burkert, Justin Lukas |d 60000 |e 60000PB1302783173 |k 0/60000/ |p 3 | ||
| 998 | |g 1013792513 |a Doyon, Fabian |m 1013792513:Doyon, Fabian |p 2 | ||
| 998 | |g 1140789880 |a Birgin, Emrullah |m 1140789880:Birgin, Emrullah |d 60000 |d 61800 |e 60000PB1140789880 |e 61800PB1140789880 |k 0/60000/ |k 1/60000/61800/ |p 1 |x j | ||
| 999 | |a KXP-PPN1859820441 |e 4377410970 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"type":{"media":"Online-Ressource","bibl":"article-journal"},"title":[{"title":"Prognostic value of disease-free interval in colorectal cancer","title_sort":"Prognostic value of disease-free interval in colorectal cancer","subtitle":"Is it time?"}],"origin":[{"dateIssuedKey":"2022","dateIssuedDisp":"26 September 2022"}],"note":["Online verfügbar: 3 June 2022, Artikelversion: 26 September 2022","Gesehen am 18.09.2023"],"id":{"eki":["1859820441"],"doi":["10.1016/j.ejso.2022.06.001"]},"physDesc":[{"extent":"7 S."}],"name":{"displayForm":["Emrullah Birgin, Fabian Doyon, Justin Burkert, Patrick Téoule, Erik Rasbach, Mohammad Rahbari, Christoph Reissfelder, Alexander Betzler, Nuh N. Rahbari"]},"relHost":[{"id":{"zdb":["2002481-2"],"issn":["1532-2157"],"eki":["320420361"]},"physDesc":[{"extent":"Online-Ressource"}],"recId":"320420361","disp":"Prognostic value of disease-free interval in colorectal cancer Is it time?European journal of surgical oncology","type":{"bibl":"periodical","media":"Online-Ressource"},"note":["Gesehen am 05.02.20"],"origin":[{"dateIssuedDisp":"1995-","publisher":"Harcourt","dateIssuedKey":"1995","publisherPlace":"Burlington, Mass."}],"pubHistory":["Nachgewiesen 21.1995 -"],"title":[{"title":"European journal of surgical oncology","title_sort":"European journal of surgical oncology"}],"titleAlt":[{"title":"EJSO"}],"part":{"year":"2022","pages":"2032-2038","text":"48(2022), 9 vom: Sept., Seite 2032-2038","issue":"9","extent":"7","volume":"48"},"language":["eng"]}],"recId":"1859820441","person":[{"display":"Birgin, Emrullah","family":"Birgin","role":"aut","given":"Emrullah"},{"display":"Doyon, Fabian","family":"Doyon","given":"Fabian","role":"aut"},{"given":"Justin Lukas","role":"aut","family":"Burkert","display":"Burkert, Justin Lukas"},{"given":"Patrick","role":"aut","family":"Téoule","display":"Téoule, Patrick"},{"display":"Rasbach, Erik","family":"Rasbach","given":"Erik","role":"aut"},{"role":"aut","given":"Mohammad","family":"Rahbari","display":"Rahbari, Mohammad"},{"family":"Reißfelder","display":"Reißfelder, Christoph","role":"aut","given":"Christoph"},{"family":"Betzler","display":"Betzler, Alexander","given":"Alexander","role":"aut"},{"given":"Nuh Nabi","role":"aut","family":"Rahbari","display":"Rahbari, Nuh Nabi"}],"language":["eng"]} | ||
| SRT | |a BIRGINEMRUPROGNOSTIC2620 | ||