Stochastic simulation of calcium microdomains in the vicinity of an L-type calcium channel
We study numerically the local dynamics of the intracellular calcium concentration in the vicinity of a voltage- and calcium-dependent plasma membrane L-type calcium channel. To account for the low number of Ca2+ ions and buffer molecules present in sub-femtoliter volumes, we use an exact stochastic...
Gespeichert in:
| Hauptverfasser: | , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2010
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| In: |
European biophysics journal
Year: 2010, Jahrgang: 39, Heft: 7, Pages: 1079-1088 |
| ISSN: | 1432-1017 |
| DOI: | 10.1007/s00249-009-0504-3 |
| Online-Zugang: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1007/s00249-009-0504-3 Verlag, lizenzpflichtig, Volltext: https://link.springer.com/article/10.1007/s00249-009-0504-3 
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| Verfasserangaben: | Frederic von Wegner, R.H.A. Fink |
MARC
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| 520 | |a We study numerically the local dynamics of the intracellular calcium concentration in the vicinity of a voltage- and calcium-dependent plasma membrane L-type calcium channel. To account for the low number of Ca2+ ions and buffer molecules present in sub-femtoliter volumes, we use an exact stochastic simulation algorithm including diffusion. We present a novel, unified simulation method that implements reaction-diffusion events of Ca2+ ions and buffer molecules, stochastic ion channel gating and channel conductance as a multivariate Markov process... | ||
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