Cover Image

Genetic instability and diminished differentiation capacity in long-term cultured mouse neurosphere cells

The potential use of neural stem cells in basic research, drug testing and for development of therapeutic strategies requires large scale in vitro amplification, increasing the probability of genetic instability and transformation. Little is known, however, about potential correlations between long-...

Full description

Saved in:
Bibliographic Details
Main Authors: Vukicevic, Vladimir (Author) , Jauch, Anna (Author) , Dinger, Timo C. (Author) , Gebauer, Linda (Author) , Hornich, Veronika (Author) , Bornstein, Stefan R. (Author) , Ehrhart-Bornstein, Monika (Author) , Müller, Albrecht M. (Author)
Format: Article (Journal)
Language:English
Published: 13 January 2010
In: Mechanisms of ageing and development
Year: 2010, Volume: 131, Issue: 2, Pages: 124-132
ISSN:1872-6216
DOI:10.1016/j.mad.2010.01.001
Online Access:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.mad.2010.01.001
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0047637410000199
Get full text
Author Notes:Vladimir Vukicevic, Anna Jauch, Timo C. Dinger, Linda Gebauer, Veronika Hornich, Stefan R. Bornstein, Monika Ehrhart-Bornstein, Albrecht M. Müller

MARC

LEADER 00000caa a2200000 c 4500
001 1859895409
003 DE-627
005 20240311123826.0
007 cr uuu---uuuuu
008 230919s2010 xx |||||o 00| ||eng c
024 7 |a 10.1016/j.mad.2010.01.001  |2 doi 
035 |a (DE-627)1859895409 
035 |a (DE-599)KXP1859895409 
035 |a (OCoLC)1425873594 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 32  |2 sdnb 
100 1 |a Vukicevic, Vladimir  |d 1969-  |e VerfasserIn  |0 (DE-588)129613746  |0 (DE-627)474758486  |0 (DE-576)297749366  |4 aut 
245 1 0 |a Genetic instability and diminished differentiation capacity in long-term cultured mouse neurosphere cells  |c Vladimir Vukicevic, Anna Jauch, Timo C. Dinger, Linda Gebauer, Veronika Hornich, Stefan R. Bornstein, Monika Ehrhart-Bornstein, Albrecht M. Müller 
264 1 |c 13 January 2010 
300 |a 9 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 19.09.2023 
520 |a The potential use of neural stem cells in basic research, drug testing and for development of therapeutic strategies requires large scale in vitro amplification, increasing the probability of genetic instability and transformation. Little is known, however, about potential correlations between long-term culture of neural stem and progenitor cells (NSPCs), changed differentiation and self-renewal capacities, and the occurrence of chromosomal instability. This study investigates the effect of extended culture time on self-renewal, differentiation capacity, cell cycle phase distribution, telomere length, telomerase activity and chromosomal stability on fetal brain-derived cells that form floating sphere colonies (neurospheres)... 
650 4 |a Aging 
650 4 |a Genetic instability 
650 4 |a Neural stem cells 
650 4 |a Telomeres 
700 1 |a Jauch, Anna  |d 1959-  |e VerfasserIn  |0 (DE-588)1025525140  |0 (DE-627)722525362  |0 (DE-576)168357496  |4 aut 
700 1 |a Dinger, Timo C.  |e VerfasserIn  |4 aut 
700 1 |a Gebauer, Linda  |e VerfasserIn  |4 aut 
700 1 |a Hornich, Veronika  |e VerfasserIn  |4 aut 
700 1 |a Bornstein, Stefan R.  |e VerfasserIn  |4 aut 
700 1 |a Ehrhart-Bornstein, Monika  |e VerfasserIn  |4 aut 
700 1 |a Müller, Albrecht M.  |e VerfasserIn  |4 aut 
773 0 8 |i Enthalten in  |t Mechanisms of ageing and development  |d Amsterdam [u.a.] : Elsevier Science, 1972  |g 131(2010), 2 vom: Feb., Seite 124-132  |h Online-Ressource  |w (DE-627)308449991  |w (DE-600)1502520-2  |w (DE-576)263808211  |x 1872-6216  |7 nnas  |a Genetic instability and diminished differentiation capacity in long-term cultured mouse neurosphere cells 
773 1 8 |g volume:131  |g year:2010  |g number:2  |g month:02  |g pages:124-132  |g extent:9  |a Genetic instability and diminished differentiation capacity in long-term cultured mouse neurosphere cells 
856 4 0 |u https://doi.org/10.1016/j.mad.2010.01.001  |x Resolving-System  |x Verlag  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u https://www.sciencedirect.com/science/article/pii/S0047637410000199  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20230919 
993 |a Article 
994 |a 2010 
998 |g 1025525140  |a Jauch, Anna  |m 1025525140:Jauch, Anna  |d 910000  |d 911500  |d 50000  |e 910000PJ1025525140  |e 911500PJ1025525140  |e 50000PJ1025525140  |k 0/910000/  |k 1/910000/911500/  |k 0/50000/  |p 2 
999 |a KXP-PPN1859895409  |e 4377733281 
BIB |a Y 
SER |a journal 
JSO |a {"id":{"doi":["10.1016/j.mad.2010.01.001"],"eki":["1859895409"]},"note":["Gesehen am 19.09.2023"],"person":[{"role":"aut","display":"Vukicevic, Vladimir","family":"Vukicevic","given":"Vladimir"},{"display":"Jauch, Anna","role":"aut","given":"Anna","family":"Jauch"},{"given":"Timo C.","family":"Dinger","display":"Dinger, Timo C.","role":"aut"},{"family":"Gebauer","given":"Linda","role":"aut","display":"Gebauer, Linda"},{"display":"Hornich, Veronika","role":"aut","given":"Veronika","family":"Hornich"},{"given":"Stefan R.","family":"Bornstein","display":"Bornstein, Stefan R.","role":"aut"},{"role":"aut","display":"Ehrhart-Bornstein, Monika","family":"Ehrhart-Bornstein","given":"Monika"},{"role":"aut","display":"Müller, Albrecht M.","given":"Albrecht M.","family":"Müller"}],"type":{"media":"Online-Ressource","bibl":"article-journal"},"language":["eng"],"title":[{"title":"Genetic instability and diminished differentiation capacity in long-term cultured mouse neurosphere cells","title_sort":"Genetic instability and diminished differentiation capacity in long-term cultured mouse neurosphere cells"}],"recId":"1859895409","relHost":[{"origin":[{"publisherPlace":"Amsterdam [u.a.]","dateIssuedKey":"1972","publisher":"Elsevier Science","dateIssuedDisp":"1972-"}],"pubHistory":["1.1972 -"],"physDesc":[{"extent":"Online-Ressource"}],"recId":"308449991","title":[{"title_sort":"Mechanisms of ageing and development","title":"Mechanisms of ageing and development"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"language":["eng"],"disp":"Genetic instability and diminished differentiation capacity in long-term cultured mouse neurosphere cellsMechanisms of ageing and development","note":["Gesehen am 20.01.20"],"part":{"pages":"124-132","volume":"131","extent":"9","issue":"2","text":"131(2010), 2 vom: Feb., Seite 124-132","year":"2010"},"id":{"zdb":["1502520-2"],"issn":["1872-6216"],"eki":["308449991"]}}],"origin":[{"dateIssuedKey":"2010","dateIssuedDisp":"13 January 2010"}],"name":{"displayForm":["Vladimir Vukicevic, Anna Jauch, Timo C. Dinger, Linda Gebauer, Veronika Hornich, Stefan R. Bornstein, Monika Ehrhart-Bornstein, Albrecht M. Müller"]},"physDesc":[{"extent":"9 S."}]} 
SRT |a VUKICEVICVGENETICINS1320 

Similar Items