Insights into the function of HDAC3 and NCoR1/NCoR2 co-repressor complex in metabolic diseases
Histone deacetylase 3 (HDAC3) and nuclear receptor co-repressor (NCoR1/2) are epigenetic regulators that play a key role in gene expression and metabolism. HDAC3 is a class I histone deacetylase that functions as a transcriptional co-repressor, modulating gene expression by removing acetyl groups fr...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
22 August 2023
|
| In: |
Frontiers in molecular biosciences
Year: 2023, Volume: 10, Pages: 1-14 |
| ISSN: | 2296-889X |
| DOI: | 10.3389/fmolb.2023.1190094 |
| Online Access: | Resolving-System, kostenfrei, Volltext: https://doi.org/10.3389/fmolb.2023.1190094 Verlag, kostenfrei, Volltext: https://www.frontiersin.org/articles/10.3389/fmolb.2023.1190094 
|
| Author Notes: | Harikrishnareddy Paluvai, Kumar D. Shanmukha, Jens Tyedmers and Johannes Backs |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1860232175 | ||
| 003 | DE-627 | ||
| 005 | 20240306102633.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230925s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3389/fmolb.2023.1190094 |2 doi | |
| 035 | |a (DE-627)1860232175 | ||
| 035 | |a (DE-599)KXP1860232175 | ||
| 035 | |a (OCoLC)1425058531 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Paluvai, Harikrishnareddy |e VerfasserIn |0 (DE-588)1303867834 |0 (DE-627)186023139X |4 aut | |
| 245 | 1 | 0 | |a Insights into the function of HDAC3 and NCoR1/NCoR2 co-repressor complex in metabolic diseases |c Harikrishnareddy Paluvai, Kumar D. Shanmukha, Jens Tyedmers and Johannes Backs |
| 264 | 1 | |c 22 August 2023 | |
| 300 | |a 14 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 25.09.2023 | ||
| 520 | |a Histone deacetylase 3 (HDAC3) and nuclear receptor co-repressor (NCoR1/2) are epigenetic regulators that play a key role in gene expression and metabolism. HDAC3 is a class I histone deacetylase that functions as a transcriptional co-repressor, modulating gene expression by removing acetyl groups from histones and non-histone proteins. NCoR1, on the other hand, is a transcriptional co-repressor that interacts with nuclear hormone receptors, including peroxisome proliferator-activated receptor gamma (PPARγ) and liver X receptor (LXR), to regulate metabolic gene expression. Recent research has revealed a functional link between HDAC3 and NCoR1 in the regulation of metabolic gene expression. Genetic deletion of HDAC3 in mouse models has been shown to improve glucose intolerance and insulin sensitivity in the liver, skeletal muscle, and adipose tissue. Similarly, genetic deletion of NCoR1 has improved insulin resistance and reduced adiposity in mouse models. Dysregulation of this interaction has been associated with the development of cardio-metabolic diseases such as cardiovascular diseases, obesity and type 2 diabetes, suggesting that targeting this pathway may hold promise for the development of novel therapeutic interventions. In this review, we summarize the current understanding of individual functions of HDAC3 and NCoR1/2 and the co-repressor complex formation (HDAC3/NCoR1/2) in different metabolic tissues. Further studies are needed to thoroughly understand the mechanisms through which HDAC3, and NCoR1/2 govern metabolic processes and the implications for treating metabolic diseases. | ||
| 700 | 1 | |a Doddi, Shanmukha K. |e VerfasserIn |0 (DE-588)1201457521 |0 (DE-627)1685181392 |4 aut | |
| 700 | 1 | |a Tyedmers, Jens |e VerfasserIn |0 (DE-588)107581765X |0 (DE-627)83396173X |0 (DE-576)444680063 |4 aut | |
| 700 | 1 | |a Backs, Johannes |d 1971- |e VerfasserIn |0 (DE-588)123819040 |0 (DE-627)706437462 |0 (DE-576)293892946 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Frontiers in molecular biosciences |d Lausanne : Frontiers, 2014 |g 10(2023) vom: Aug., Artikel-ID 1190094, Seite 1-14 |h Online-Ressource |w (DE-627)820039691 |w (DE-600)2814330-9 |w (DE-576)427947782 |x 2296-889X |7 nnas |a Insights into the function of HDAC3 and NCoR1/NCoR2 co-repressor complex in metabolic diseases |
| 773 | 1 | 8 | |g volume:10 |g year:2023 |g month:08 |g elocationid:1190094 |g pages:1-14 |g extent:14 |a Insights into the function of HDAC3 and NCoR1/NCoR2 co-repressor complex in metabolic diseases |
| 856 | 4 | 0 | |u https://doi.org/10.3389/fmolb.2023.1190094 |x Resolving-System |x Verlag |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.frontiersin.org/articles/10.3389/fmolb.2023.1190094 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20230925 | ||
| 993 | |a Article | ||
| 994 | |a 2023 | ||
| 998 | |g 123819040 |a Backs, Johannes |m 123819040:Backs, Johannes |d 910000 |d 910100 |e 910000PB123819040 |e 910100PB123819040 |k 0/910000/ |k 1/910000/910100/ |p 4 |y j | ||
| 998 | |g 107581765X |a Tyedmers, Jens |m 107581765X:Tyedmers, Jens |d 910000 |d 910100 |e 910000PT107581765X |e 910100PT107581765X |k 0/910000/ |k 1/910000/910100/ |p 3 | ||
| 998 | |g 1201457521 |a Doddi, Shanmukha K. |m 1201457521:Doddi, Shanmukha K. |d 910000 |d 910100 |e 910000PD1201457521 |e 910100PD1201457521 |k 0/910000/ |k 1/910000/910100/ |p 2 | ||
| 998 | |g 1303867834 |a Pulavai, Harikrishnareddy |m 1303867834:Pulavai, Harikrishnareddy |d 910000 |d 910100 |e 910000PP1303867834 |e 910100PP1303867834 |k 0/910000/ |k 1/910000/910100/ |p 1 |x j | ||
| 999 | |a KXP-PPN1860232175 |e 4378869144 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"type":{"media":"Online-Ressource","bibl":"article-journal"},"person":[{"roleDisplay":"VerfasserIn","family":"Paluvai","display":"Paluvai, Harikrishnareddy","role":"aut","given":"Harikrishnareddy"},{"given":"Shanmukha K.","role":"aut","roleDisplay":"VerfasserIn","display":"Doddi, Shanmukha K.","family":"Doddi"},{"given":"Jens","role":"aut","roleDisplay":"VerfasserIn","family":"Tyedmers","display":"Tyedmers, Jens"},{"roleDisplay":"VerfasserIn","family":"Backs","display":"Backs, Johannes","given":"Johannes","role":"aut"}],"title":[{"title_sort":"Insights into the function of HDAC3 and NCoR1/NCoR2 co-repressor complex in metabolic diseases","title":"Insights into the function of HDAC3 and NCoR1/NCoR2 co-repressor complex in metabolic diseases"}],"note":["Gesehen am 25.09.2023"],"recId":"1860232175","physDesc":[{"extent":"14 S."}],"id":{"eki":["1860232175"],"doi":["10.3389/fmolb.2023.1190094"]},"language":["eng"],"relHost":[{"type":{"bibl":"periodical","media":"Online-Ressource"},"part":{"text":"10(2023) vom: Aug., Artikel-ID 1190094, Seite 1-14","pages":"1-14","extent":"14","year":"2023","volume":"10"},"note":["Gesehen am 12.08.20"],"title":[{"title":"Frontiers in molecular biosciences","title_sort":"Frontiers in molecular biosciences"}],"origin":[{"dateIssuedKey":"2014","publisherPlace":"Lausanne","dateIssuedDisp":"2014-","publisher":"Frontiers"}],"recId":"820039691","pubHistory":["1.2014 -"],"disp":"Insights into the function of HDAC3 and NCoR1/NCoR2 co-repressor complex in metabolic diseasesFrontiers in molecular biosciences","id":{"eki":["820039691"],"issn":["2296-889X"],"zdb":["2814330-9"]},"language":["eng"],"physDesc":[{"extent":"Online-Ressource"}]}],"name":{"displayForm":["Harikrishnareddy Paluvai, Kumar D. Shanmukha, Jens Tyedmers and Johannes Backs"]},"origin":[{"dateIssuedKey":"2023","dateIssuedDisp":"22 August 2023"}]} | ||
| SRT | |a PALUVAIHARINSIGHTSIN2220 | ||