Cover Image

Autoantibodies to polymorphonuclear neutrophil elastase do not inhibit but enhance elastase activity

Polymorphonuclear neutrophils (PMNs) of patients with active Wegener's granulomatosis and PMN activated in vitro express elastase on their surface as detected by autoantibodies derived from patients with ANCA- positive vasculitis or chronic staphylococcus infections. The PMN- associated elastas...

Full description

Saved in:
Bibliographic Details
Main Authors: Morcos, Michael (Author) , Zimmermann, F. (Author) , Radsak, Markus Philipp (Author) , Wörner, Inga (Author) , Kramer, Michael D. (Author) , Roland, J. (Author) , Hänsch, Gertrud Maria (Author) , Andrassy, Konrad (Author)
Format: Article (Journal)
Language:English
Published: 1998
In: American journal of kidney diseases
Year: 1998, Volume: 31, Issue: 6, Pages: 978-985
ISSN:1523-6838
DOI:10.1053/ajkd.1998.v31.pm9631842
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1053/ajkd.1998.v31.pm9631842
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0272638698001486
Get full text
Author Notes:M Morcos, F Zimmermann, M Radsak, I Worner, MD Kramer, J Roland, GM Hansch, K Andrassy

MARC

LEADER 00000caa a2200000 c 4500
001 1860245072
003 DE-627
005 20240311143521.0
007 cr uuu---uuuuu
008 230925s1998 xx |||||o 00| ||eng c
024 7 |a 10.1053/ajkd.1998.v31.pm9631842  |2 doi 
035 |a (DE-627)1860245072 
035 |a (DE-599)KXP1860245072 
035 |a (OCoLC)1425888978 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Morcos, Michael  |d 1966-  |e VerfasserIn  |0 (DE-588)1071415662  |0 (DE-627)825827272  |0 (DE-576)433067470  |4 aut 
245 1 0 |a Autoantibodies to polymorphonuclear neutrophil elastase do not inhibit but enhance elastase activity  |c M Morcos, F Zimmermann, M Radsak, I Worner, MD Kramer, J Roland, GM Hansch, K Andrassy 
264 1 |c 1998 
300 |a 8 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Elektronische Reproduktion der Druck-Ausgabe 21. Februar 2008 
500 |a Gesehen am 25.09.2023 
520 |a Polymorphonuclear neutrophils (PMNs) of patients with active Wegener's granulomatosis and PMN activated in vitro express elastase on their surface as detected by autoantibodies derived from patients with ANCA- positive vasculitis or chronic staphylococcus infections. The PMN- associated elastase was enzymatically active. By affinity-purified autoantibodies to elastase, the enzymatic activity was further enhanced as measured either by a chromogenic peptide or by elastin as substrate. Antibodies to human elastase from mouse or from sheep also enhanced elastase activity, whereas unrelated immunoglobulins had no effect. Taken together, our data indicate that autoantibodies to elastase are not inhibitory but upregulate the elastase activity and thereby might contribute to tissue damage. (Am J Kidney Dis 1998 Jun;31(6):978-85) 
700 1 |a Zimmermann, F.  |e VerfasserIn  |4 aut 
700 1 |a Radsak, Markus Philipp  |d 1973-  |e VerfasserIn  |0 (DE-588)122217713  |0 (DE-627)081810172  |0 (DE-576)293157936  |4 aut 
700 1 |a Wörner, Inga  |e VerfasserIn  |0 (DE-588)1145351778  |0 (DE-627)1005572224  |0 (DE-576)167516132  |4 aut 
700 1 |a Kramer, Michael D.  |d 1958-  |e VerfasserIn  |0 (DE-588)172195608  |0 (DE-627)697109488  |0 (DE-576)133065863  |4 aut 
700 1 |a Roland, J.  |e VerfasserIn  |4 aut 
700 1 |a Hänsch, Gertrud Maria  |e VerfasserIn  |0 (DE-588)1032383380  |0 (DE-627)738394076  |0 (DE-576)323810926  |4 aut 
700 1 |a Andrassy, Konrad  |e VerfasserIn  |0 (DE-588)1076338119  |0 (DE-627)834722216  |0 (DE-576)445217197  |4 aut 
773 0 8 |i Enthalten in  |t American journal of kidney diseases  |d Philadelphia, Pa. : Elsevier Saunders, 1981  |g 31(1998), 6, Seite 978-985  |h Online-Ressource  |w (DE-627)320593169  |w (DE-600)2019205-8  |w (DE-576)091138760  |x 1523-6838  |7 nnas  |a Autoantibodies to polymorphonuclear neutrophil elastase do not inhibit but enhance elastase activity 
773 1 8 |g volume:31  |g year:1998  |g number:6  |g pages:978-985  |g extent:8  |a Autoantibodies to polymorphonuclear neutrophil elastase do not inhibit but enhance elastase activity 
856 4 0 |u https://doi.org/10.1053/ajkd.1998.v31.pm9631842  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u https://www.sciencedirect.com/science/article/pii/S0272638698001486  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20230925 
993 |a Article 
994 |a 1998 
998 |g 1076338119  |a Andrassy, Konrad  |m 1076338119:Andrassy, Konrad  |d 910000  |d 910100  |e 910000PA1076338119  |e 910100PA1076338119  |k 0/910000/  |k 1/910000/910100/  |p 8  |y j 
998 |g 1032383380  |a Hänsch, Gertrud Maria  |m 1032383380:Hänsch, Gertrud Maria  |d 910000  |d 911600  |e 910000PH1032383380  |e 911600PH1032383380  |k 0/910000/  |k 1/910000/911600/  |p 7 
998 |g 172195608  |a Kramer, Michael D.  |m 172195608:Kramer, Michael D.  |d 910000  |d 911600  |e 910000PK172195608  |e 911600PK172195608  |k 0/910000/  |k 1/910000/911600/  |p 5 
998 |g 1145351778  |a Wörner, Inga  |m 1145351778:Wörner, Inga  |d 50000  |e 50000PW1145351778  |k 0/50000/  |p 4 
998 |g 122217713  |a Radsak, Markus Philipp  |m 122217713:Radsak, Markus Philipp  |d 910000  |d 911600  |e 910000PR122217713  |e 911600PR122217713  |k 0/910000/  |k 1/910000/911600/  |p 3 
998 |g 1071415662  |a Morcos, Michael  |m 1071415662:Morcos, Michael  |d 910000  |d 910100  |e 910000PM1071415662  |e 910100PM1071415662  |k 0/910000/  |k 1/910000/910100/  |p 1  |x j 
999 |a KXP-PPN1860245072  |e 4378899957 
BIB |a Y 
SER |a journal 
JSO |a {"type":{"media":"Online-Ressource","bibl":"article-journal"},"title":[{"title_sort":"Autoantibodies to polymorphonuclear neutrophil elastase do not inhibit but enhance elastase activity","title":"Autoantibodies to polymorphonuclear neutrophil elastase do not inhibit but enhance elastase activity"}],"origin":[{"dateIssuedDisp":"1998","dateIssuedKey":"1998"}],"relHost":[{"corporate":[{"roleDisplay":"Herausgebendes Organ","role":"isb","display":"National Kidney Foundation"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"title":[{"subtitle":"AJKD ; official journal of the National Kidney Foundation","title_sort":"American journal of kidney diseases","title":"American journal of kidney diseases"}],"titleAlt":[{"title":"AJKD"}],"origin":[{"publisher":"Elsevier Saunders","dateIssuedDisp":"1981-","publisherPlace":"Philadelphia, Pa.","dateIssuedKey":"1981"}],"part":{"volume":"31","extent":"8","pages":"978-985","text":"31(1998), 6, Seite 978-985","issue":"6","year":"1998"},"disp":"Autoantibodies to polymorphonuclear neutrophil elastase do not inhibit but enhance elastase activityAmerican journal of kidney diseases","language":["eng"],"physDesc":[{"extent":"Online-Ressource"}],"pubHistory":["1.1981 -"],"id":{"eki":["320593169"],"issn":["1523-6838"],"zdb":["2019205-8"]},"recId":"320593169"}],"language":["eng"],"physDesc":[{"extent":"8 S."}],"note":["Elektronische Reproduktion der Druck-Ausgabe 21. Februar 2008","Gesehen am 25.09.2023"],"name":{"displayForm":["M Morcos, F Zimmermann, M Radsak, I Worner, MD Kramer, J Roland, GM Hansch, K Andrassy"]},"person":[{"display":"Morcos, Michael","role":"aut","roleDisplay":"VerfasserIn","given":"Michael","family":"Morcos"},{"given":"F.","family":"Zimmermann","role":"aut","display":"Zimmermann, F.","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","display":"Radsak, Markus Philipp","role":"aut","given":"Markus Philipp","family":"Radsak"},{"given":"Inga","family":"Wörner","roleDisplay":"VerfasserIn","role":"aut","display":"Wörner, Inga"},{"given":"Michael D.","family":"Kramer","display":"Kramer, Michael D.","role":"aut","roleDisplay":"VerfasserIn"},{"roleDisplay":"VerfasserIn","display":"Roland, J.","role":"aut","given":"J.","family":"Roland"},{"role":"aut","display":"Hänsch, Gertrud Maria","roleDisplay":"VerfasserIn","given":"Gertrud Maria","family":"Hänsch"},{"roleDisplay":"VerfasserIn","display":"Andrassy, Konrad","role":"aut","given":"Konrad","family":"Andrassy"}],"id":{"eki":["1860245072"],"doi":["10.1053/ajkd.1998.v31.pm9631842"]},"recId":"1860245072"} 
SRT |a MORCOSMICHAUTOANTIBO1998 

Similar Items