Cover Image

Non-neuronal acetylcholinesterase activity shows limited utility for early detection of sepsis

Sepsis is a severe systemic inflammatory condition characterized by rapid clinical deterioration and organ dysfunction. The cholinergic system has been implicated in modulating the inflammatory response. Acetylcholinesterase (AChE), an enzyme primarily responsible for the hydrolysis of acetylcholine...

Full description

Saved in:
Bibliographic Details
Main Authors: Živković, Aleksandar (Author) , Schmidt, Karsten (Author) , Hofer, Stefan (Author) , Brenner, Thorsten (Author) , Weigand, Markus A. (Author) , Decker, Sebastian (Author)
Format: Article (Journal)
Language:English
Published: 26 July 2023
In: Biomedicines
Year: 2023, Volume: 11, Issue: 8, Pages: 1-11
ISSN:2227-9059
DOI:10.3390/biomedicines11082111
Online Access:Verlag, kostenfrei, Volltext: https://doi.org/10.3390/biomedicines11082111
Verlag, kostenfrei, Volltext: https://www.mdpi.com/2227-9059/11/8/2111
Get full text
Author Notes:Aleksandar R. Zivkovic, Karsten Schmidt, Stefan Hofer, Thorsten Brenner, Markus A. Weigand and Sebastian O. Decker

MARC

LEADER 00000caa a2200000 c 4500
001 1860339247
003 DE-627
005 20240307052920.0
007 cr uuu---uuuuu
008 230927s2023 xx |||||o 00| ||eng c
024 7 |a 10.3390/biomedicines11082111  |2 doi 
035 |a (DE-627)1860339247 
035 |a (DE-599)KXP1860339247 
035 |a (OCoLC)1425210999 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Živković, Aleksandar  |d 1976-  |e VerfasserIn  |0 (DE-588)133065200  |0 (DE-627)533317223  |0 (DE-576)265580633  |4 aut 
245 1 0 |a Non-neuronal acetylcholinesterase activity shows limited utility for early detection of sepsis  |c Aleksandar R. Zivkovic, Karsten Schmidt, Stefan Hofer, Thorsten Brenner, Markus A. Weigand and Sebastian O. Decker 
264 1 |c 26 July 2023 
300 |b Illustrationen 
300 |a 11 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Gesehen am 29.11.2023 
520 |a Sepsis is a severe systemic inflammatory condition characterized by rapid clinical deterioration and organ dysfunction. The cholinergic system has been implicated in modulating the inflammatory response. Acetylcholinesterase (AChE), an enzyme primarily responsible for the hydrolysis of acetylcholine, has been proposed as a potential early indicator of sepsis onset. However, the exact role of non-neuronal AChE activity in sepsis and its correlation with disease severity and patient outcomes remain unclear. This study aimed to investigate the involvement of AChE activity in sepsis and evaluate its association with disease severity and clinical outcomes. 
650 4 |a cholinergic anti-inflammatory pathway 
650 4 |a cholinesterase 
650 4 |a extrasynaptic 
650 4 |a infection 
650 4 |a inflammatory response 
650 4 |a intensive care unit 
650 4 |a neuro-immune 
700 1 |a Schmidt, Karsten  |d 1983-  |e VerfasserIn  |0 (DE-588)141624841  |0 (DE-627)63039475X  |0 (DE-576)324449690  |4 aut 
700 1 |a Hofer, Stefan  |d 1971-  |e VerfasserIn  |0 (DE-588)122418506  |0 (DE-627)70590072X  |0 (DE-576)187683867  |4 aut 
700 1 |a Brenner, Thorsten  |d 1978-  |e VerfasserIn  |0 (DE-588)130125709  |0 (DE-627)491713363  |0 (DE-576)189360607  |4 aut 
700 1 |a Weigand, Markus A.  |d 1967-  |e VerfasserIn  |0 (DE-588)1064970435  |0 (DE-627)815375239  |0 (DE-576)424658666  |4 aut 
700 1 |a Decker, Sebastian  |d 1984-  |e VerfasserIn  |0 (DE-588)139936041  |0 (DE-627)703511785  |0 (DE-576)313600880  |4 aut 
773 0 8 |i Enthalten in  |t Biomedicines  |d Basel : MDPI, 2013  |g 11(2023), 8, Artikel-ID 2111, Seite 1-11  |h Online-Ressource  |w (DE-627)750370483  |w (DE-600)2720867-9  |w (DE-576)384589596  |x 2227-9059  |7 nnas  |a Non-neuronal acetylcholinesterase activity shows limited utility for early detection of sepsis 
773 1 8 |g volume:11  |g year:2023  |g number:8  |g elocationid:2111  |g pages:1-11  |g extent:11  |a Non-neuronal acetylcholinesterase activity shows limited utility for early detection of sepsis 
856 4 0 |u https://doi.org/10.3390/biomedicines11082111  |x Verlag  |x Resolving-System  |z kostenfrei  |3 Volltext 
856 4 0 |u https://www.mdpi.com/2227-9059/11/8/2111  |x Verlag  |z kostenfrei  |3 Volltext 
951 |a AR 
992 |a 20230927 
993 |a Article 
994 |a 2023 
998 |g 139936041  |a Decker, Sebastian  |m 139936041:Decker, Sebastian  |d 910000  |d 910300  |d 50000  |e 910000PD139936041  |e 910300PD139936041  |e 50000PD139936041  |k 0/910000/  |k 1/910000/910300/  |k 0/50000/  |p 6  |y j 
998 |g 1064970435  |a Weigand, Markus A.  |m 1064970435:Weigand, Markus A.  |d 910000  |d 910300  |e 910000PW1064970435  |e 910300PW1064970435  |k 0/910000/  |k 1/910000/910300/  |p 5 
998 |g 130125709  |a Brenner, Thorsten  |m 130125709:Brenner, Thorsten  |d 50000  |e 50000PB130125709  |k 0/50000/  |p 4 
998 |g 122418506  |a Hofer, Stefan  |m 122418506:Hofer, Stefan  |d 50000  |e 50000PH122418506  |k 0/50000/  |p 3 
998 |g 133065200  |a Živković, Aleksandar  |m 133065200:Živković, Aleksandar  |d 50000  |e 50000PZ133065200  |k 0/50000/  |p 1  |x j 
999 |a KXP-PPN1860339247  |e 4379453405 
BIB |a Y 
SER |a journal 
JSO |a {"note":["Gesehen am 29.11.2023"],"recId":"1860339247","person":[{"given":"Aleksandar","display":"Živković, Aleksandar","role":"aut","family":"Živković"},{"given":"Karsten","display":"Schmidt, Karsten","role":"aut","family":"Schmidt"},{"display":"Hofer, Stefan","given":"Stefan","role":"aut","family":"Hofer"},{"given":"Thorsten","display":"Brenner, Thorsten","role":"aut","family":"Brenner"},{"display":"Weigand, Markus A.","given":"Markus A.","family":"Weigand","role":"aut"},{"given":"Sebastian","display":"Decker, Sebastian","family":"Decker","role":"aut"}],"language":["eng"],"name":{"displayForm":["Aleksandar R. Zivkovic, Karsten Schmidt, Stefan Hofer, Thorsten Brenner, Markus A. Weigand and Sebastian O. Decker"]},"origin":[{"dateIssuedKey":"2023","dateIssuedDisp":"26 July 2023"}],"relHost":[{"type":{"media":"Online-Ressource","bibl":"periodical"},"disp":"Non-neuronal acetylcholinesterase activity shows limited utility for early detection of sepsisBiomedicines","language":["eng"],"part":{"text":"11(2023), 8, Artikel-ID 2111, Seite 1-11","issue":"8","extent":"11","pages":"1-11","volume":"11","year":"2023"},"note":["Gesehen am 12.08.20"],"pubHistory":["1.2013 -"],"title":[{"title":"Biomedicines","subtitle":"open access journal","title_sort":"Biomedicines"}],"physDesc":[{"extent":"Online-Ressource"}],"id":{"issn":["2227-9059"],"eki":["750370483"],"zdb":["2720867-9"]},"origin":[{"dateIssuedKey":"2013","publisherPlace":"Basel","publisher":"MDPI","dateIssuedDisp":"2013-"}],"recId":"750370483"}],"id":{"doi":["10.3390/biomedicines11082111"],"eki":["1860339247"]},"physDesc":[{"extent":"11 S.","noteIll":"Illustrationen"}],"title":[{"title":"Non-neuronal acetylcholinesterase activity shows limited utility for early detection of sepsis","title_sort":"Non-neuronal acetylcholinesterase activity shows limited utility for early detection of sepsis"}],"type":{"bibl":"article-journal","media":"Online-Ressource"}} 
SRT |a ZIVKOVICALNONNEURONA2620 

Similar Items