Enhancing immunotherapy response in melanoma: myeloid-derived suppressor cells as a therapeutic target
Despite the remarkable success of immune checkpoint inhibitors (ICIs) in melanoma treatment, resistance to them remains a substantial clinical challenge. Myeloid-derived suppressor cells (MDSCs) represent a heterogeneous population of myeloid cells that can suppress antitumor immune responses mediat...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article (Journal) |
| Language: | English |
| Published: |
2023
|
| In: |
The journal of clinical investigation
Year: 2023, Volume: 133, Issue: 13, Pages: 1-12 |
| ISSN: | 1558-8238 |
| DOI: | 10.1172/JCI170762 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1172/JCI170762 Verlag, kostenfrei, Volltext: https://www.jci.org/articles/view/170762 
|
| Author Notes: | Feyza Gul Ozbay Kurt, Samantha Lasser, Ihor Arkhypov, Jochen Utikal, and Viktor Umansky |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1860415598 | ||
| 003 | DE-627 | ||
| 005 | 20240307052645.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 230928s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1172/JCI170762 |2 doi | |
| 035 | |a (DE-627)1860415598 | ||
| 035 | |a (DE-599)KXP1860415598 | ||
| 035 | |a (OCoLC)1425211074 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Özbay Kurt, Feyza Gül |d 1992- |e VerfasserIn |0 (DE-588)1284914275 |0 (DE-627)1840611251 |4 aut | |
| 245 | 1 | 0 | |a Enhancing immunotherapy response in melanoma |b myeloid-derived suppressor cells as a therapeutic target |c Feyza Gul Ozbay Kurt, Samantha Lasser, Ihor Arkhypov, Jochen Utikal, and Viktor Umansky |
| 264 | 1 | |c 2023 | |
| 300 | |b Illustrationen | ||
| 300 | |a 12 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Veröffentlicht: 3. Juli 2023 | ||
| 500 | |a Gesehen am 28.09.2023 | ||
| 520 | |a Despite the remarkable success of immune checkpoint inhibitors (ICIs) in melanoma treatment, resistance to them remains a substantial clinical challenge. Myeloid-derived suppressor cells (MDSCs) represent a heterogeneous population of myeloid cells that can suppress antitumor immune responses mediated by T and natural killer cells and promote tumor growth. They are major contributors to ICI resistance and play a crucial role in creating an immunosuppressive tumor microenvironment. Therefore, targeting MDSCs is considered a promising strategy to improve the therapeutic efficacy of ICIs. This Review describes the mechanism of MDSC-mediated immune suppression, preclinical and clinical studies on MDSC targeting, and potential strategies for inhibiting MDSC functions to improve melanoma immunotherapy. | ||
| 700 | 1 | |a Lasser, Samantha |d 1990- |e VerfasserIn |0 (DE-588)1227276850 |0 (DE-627)174833753X |4 aut | |
| 700 | 1 | |a Arkhypov, Ihor |d 1995- |e VerfasserIn |0 (DE-588)122727694X |0 (DE-627)1748337882 |4 aut | |
| 700 | 1 | |a Utikal, Jochen |d 1974- |e VerfasserIn |0 (DE-588)1026463750 |0 (DE-627)726765015 |0 (DE-576)371816580 |4 aut | |
| 700 | 1 | |a Umansky, Viktor |d 1955- |e VerfasserIn |0 (DE-588)102885756X |0 (DE-627)731733207 |0 (DE-576)376300078 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t The journal of clinical investigation |d Ann Arbor, Mich. : ASCJ, 1924 |g 133(2023), 13, Artikel-ID e170762, Seite 1-12 |h Online-Ressource |w (DE-627)316004677 |w (DE-600)2018375-6 |w (DE-576)094950423 |x 1558-8238 |7 nnas |a Enhancing immunotherapy response in melanoma myeloid-derived suppressor cells as a therapeutic target |
| 773 | 1 | 8 | |g volume:133 |g year:2023 |g number:13 |g elocationid:e170762 |g pages:1-12 |g extent:12 |a Enhancing immunotherapy response in melanoma myeloid-derived suppressor cells as a therapeutic target |
| 856 | 4 | 0 | |u https://doi.org/10.1172/JCI170762 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.jci.org/articles/view/170762 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20230928 | ||
| 993 | |a Article | ||
| 994 | |a 2023 | ||
| 998 | |g 102885756X |a Umansky, Viktor |m 102885756X:Umansky, Viktor |d 60000 |d 60000 |d 61900 |d 140000 |e 60000PU102885756X |e 60000PU102885756X |e 61900PU102885756X |e 140000PU102885756X |k 0/60000/ |k 0/60000/ |k 1/60000/61900/ |k 0/140000/ |p 5 |y j | ||
| 998 | |g 1026463750 |a Utikal, Jochen |m 1026463750:Utikal, Jochen |d 60000 |e 60000PU1026463750 |k 0/60000/ |p 4 | ||
| 998 | |g 122727694X |a Arkhypov, Ihor |m 122727694X:Arkhypov, Ihor |d 910000 |d 912000 |e 910000PA122727694X |e 912000PA122727694X |k 0/910000/ |k 1/910000/912000/ |p 3 | ||
| 998 | |g 1227276850 |a Lasser, Samantha |m 1227276850:Lasser, Samantha |d 60000 |d 61900 |e 60000PL1227276850 |e 61900PL1227276850 |k 0/60000/ |k 1/60000/61900/ |p 2 | ||
| 998 | |g 1284914275 |a Özbay Kurt, Feyza Gül |m 1284914275:Özbay Kurt, Feyza Gül |d 140000 |e 140000PO1284914275 |k 0/140000/ |p 1 |x j | ||
| 999 | |a KXP-PPN1860415598 |e 4379660605 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"recId":"1860415598","id":{"doi":["10.1172/JCI170762"],"eki":["1860415598"]},"title":[{"title_sort":"Enhancing immunotherapy response in melanoma","title":"Enhancing immunotherapy response in melanoma","subtitle":"myeloid-derived suppressor cells as a therapeutic target"}],"note":["Veröffentlicht: 3. Juli 2023","Gesehen am 28.09.2023"],"physDesc":[{"extent":"12 S.","noteIll":"Illustrationen"}],"person":[{"family":"Özbay Kurt","roleDisplay":"VerfasserIn","display":"Özbay Kurt, Feyza Gül","role":"aut","given":"Feyza Gül"},{"given":"Samantha","display":"Lasser, Samantha","role":"aut","roleDisplay":"VerfasserIn","family":"Lasser"},{"display":"Arkhypov, Ihor","role":"aut","given":"Ihor","roleDisplay":"VerfasserIn","family":"Arkhypov"},{"roleDisplay":"VerfasserIn","family":"Utikal","role":"aut","display":"Utikal, Jochen","given":"Jochen"},{"roleDisplay":"VerfasserIn","family":"Umansky","given":"Viktor","role":"aut","display":"Umansky, Viktor"}],"name":{"displayForm":["Feyza Gul Ozbay Kurt, Samantha Lasser, Ihor Arkhypov, Jochen Utikal, and Viktor Umansky"]},"relHost":[{"recId":"316004677","corporate":[{"role":"isb","display":"American Society for Clinical Investigation","roleDisplay":"Herausgebendes Organ"}],"pubHistory":["1.1924/25 -"],"titleAlt":[{"title":"JCI"}],"language":["eng"],"origin":[{"dateIssuedDisp":"1924-","dateIssuedKey":"1924","publisherPlace":"Ann Arbor, Mich.","publisher":"ASCJ"}],"type":{"media":"Online-Ressource","bibl":"periodical"},"part":{"text":"133(2023), 13, Artikel-ID e170762, Seite 1-12","issue":"13","volume":"133","extent":"12","year":"2023","pages":"1-12"},"physDesc":[{"extent":"Online-Ressource"}],"note":["Gesehen am 25.01.2022","Fortsetzung der Druck-Ausgabe"],"disp":"Enhancing immunotherapy response in melanoma myeloid-derived suppressor cells as a therapeutic targetThe journal of clinical investigation","id":{"eki":["316004677"],"zdb":["2018375-6"],"issn":["1558-8238"]},"title":[{"subtitle":"JCI ; the publication of the American Society for Clinical Investigation","title":"The journal of clinical investigation","title_sort":"journal of clinical investigation"}]}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"origin":[{"dateIssuedKey":"2023","dateIssuedDisp":"2023"}],"language":["eng"]} | ||
| SRT | |a OEZBAYKURTENHANCINGI2023 | ||