Self-assembled liposome-loaded microbubbles: the missing link for safe and efficient ultrasound triggered drug-delivery
Liposome-loaded microbubbles have been recently introduced as a promising drug delivery platform for ultrasound guided drug delivery. In this paper we design liposome-loaded (lipid-shelled) microbubbles through the simple self-assembly of the involved compounds in a single step process. We thoroughl...
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| Hauptverfasser: | , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
26 February 2011
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| In: |
Journal of controlled release
Year: 2011, Jahrgang: 152, Heft: 2, Pages: 249-256 |
| ISSN: | 1873-4995 |
| DOI: | 10.1016/j.jconrel.2011.02.024 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jconrel.2011.02.024 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S016836591100109X 
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| Verfasserangaben: | Bart Geers, Ine Lentacker, Niek N. Sanders, Joseph Demeester, Stephen Meairs, Stefaan C. De Smedt |
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| 520 | |a Liposome-loaded microbubbles have been recently introduced as a promising drug delivery platform for ultrasound guided drug delivery. In this paper we design liposome-loaded (lipid-shelled) microbubbles through the simple self-assembly of the involved compounds in a single step process. We thoroughly characterized the liposome-loading of the microbubbles and evaluated the cell killing efficiency of this material using doxorubicin (DOX) as a model drug. Importantly, we observed that the DOX liposome-loaded microbubbles allowed killing of melanoma cells even at very low doses of DOX. These findings clearly prove the potential of liposome-loaded microbubbles for ultrasound targeted drug delivery to cancer tissues. | ||
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| 650 | 4 | |a Drug-delivery | |
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| 650 | 4 | |a Ultrasound | |
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