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Effect of CYP2C19 and ABCB1 single nucleotide polymorphisms on outcomes of treatment with ticagrelor versus clopidogrel for acute coronary syndromes: a genetic substudy of the PLATO trial

In the PLATO trial of ticagrelor versus clopidogrel for treatment of acute coronary syndromes, ticagrelor reduced the composite outcome of cardiovascular death, myocardial infarction, and stroke, but increased events of major bleeding related to non-coronary artery bypass graft (CABG). CYP2C19 and A...

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Hauptverfasser: Wallentin, Lars (VerfasserIn) , James, Stefan (VerfasserIn) , Storey, Robert F (VerfasserIn) , Armstrong, Martin (VerfasserIn) , Barratt, Bryan J (VerfasserIn) , Horrow, Jay (VerfasserIn) , Husted, Steen (VerfasserIn) , Katus, Hugo (VerfasserIn) , Steg, P Gabriel (VerfasserIn) , Shah, Svati H (VerfasserIn) , Becker, Richard C (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: August 29, 2010
In: The lancet
Year: 2010, Jahrgang: 376, Heft: 9749, Pages: 1320-1328
ISSN:1474-547X
DOI:10.1016/S0140-6736(10)61274-3
Online-Zugang:Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1016/S0140-6736(10)61274-3
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0140673610612743
Volltext
Verfasserangaben:Lars Wallentin, Stefan James, Robert F Storey, Martin Armstrong, Bryan J Barratt, Jay Horrow, Steen Husted, Hugo Katus, P Gabriel Steg, Svati H Shah, Richard C Becker, for the PLATO investigators
Beschreibung
Zusammenfassung:In the PLATO trial of ticagrelor versus clopidogrel for treatment of acute coronary syndromes, ticagrelor reduced the composite outcome of cardiovascular death, myocardial infarction, and stroke, but increased events of major bleeding related to non-coronary artery bypass graft (CABG). CYP2C19 and ABCB1 genotypes are known to influence the effects of clopidogrel. In this substudy, we investigated the effects of these genotypes on outcomes between and within treatment groups.
Beschreibung:Gesehen am 28.09.2023
Beschreibung:Online Resource
ISSN:1474-547X
DOI:10.1016/S0140-6736(10)61274-3

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