IGSF3-mediated potassium dysregulation promotes neuronal hyperexcitability and glioma progression

Glioblastomas are incurable tumors often associated with epileptic seizures. In a recent study published in Neuron, Curry et al. demonstrated a novel function of the membrane protein IGSF3 that induces potassium dysregulation, neuronal hyperexcitability, and tumor progression. This work uncovers a n...

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1. Verfasser: Venkataramani, Varun (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: June 2023
In: Trends in cancer
Year: 2023, Jahrgang: 9, Heft: 6, Pages: 457-458
ISSN:2405-8025
DOI:10.1016/j.trecan.2023.04.005
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.trecan.2023.04.005
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S2405803323000614
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Verfasserangaben:Varun Venkataramani

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520 |a Glioblastomas are incurable tumors often associated with epileptic seizures. In a recent study published in Neuron, Curry et al. demonstrated a novel function of the membrane protein IGSF3 that induces potassium dysregulation, neuronal hyperexcitability, and tumor progression. This work uncovers a novel layer of bidirectional neuron-tumor communication, further underlining the importance of comprehensively investigating neuron-tumor networks in glioblastoma. 
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650 4 |a neuronal hyperexcitability 
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