RIC-3 exclusively enhances the surface expression of human homomeric 5-hydroxytryptamine type 3A (5-HT3A) receptors despite direct interactions with 5-HT3A, -C, -D, and -E subunits
Although five 5-hydroxytryptamine type 3 (5-HT3) subunits (A-E) have been cloned, knowledge on the regulation of their assembly is limited. RIC-3 has been identified as a chaperone specific for the pentameric ligand-gated nicotinic acetylcholine and 5-HT3 receptors. Therefore, we examined the impact...
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| Hauptverfasser: | , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
June 3, 2010
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| In: |
The journal of biological chemistry
Year: 2010, Jahrgang: 285, Heft: 35, Pages: 26956-26965 |
| ISSN: | 1083-351X |
| DOI: | 10.1074/jbc.M110.122838 |
| Online-Zugang: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1074/jbc.M110.122838 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S002192582059488X 
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| Verfasserangaben: | Jutta Walstab, Christian Hammer, Felix Lasitschka, Dorothee Möller, Christopher N. Connolly, Gudrun Rappold, Michael Brüss, Heinz Bönisch, and Beate Niesler |
MARC
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| 245 | 1 | 0 | |a RIC-3 exclusively enhances the surface expression of human homomeric 5-hydroxytryptamine type 3A (5-HT3A) receptors despite direct interactions with 5-HT3A, -C, -D, and -E subunits |c Jutta Walstab, Christian Hammer, Felix Lasitschka, Dorothee Möller, Christopher N. Connolly, Gudrun Rappold, Michael Brüss, Heinz Bönisch, and Beate Niesler |
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| 520 | |a Although five 5-hydroxytryptamine type 3 (5-HT3) subunits (A-E) have been cloned, knowledge on the regulation of their assembly is limited. RIC-3 has been identified as a chaperone specific for the pentameric ligand-gated nicotinic acetylcholine and 5-HT3 receptors. Therefore, we examined the impact of RIC-3 on differently composed 5-HT3 receptors with the focus on 5-HT3C, -D, and -E subunits. The influence of RIC-3 on these receptor subtypes is supported by the presence of RIC3 mRNA in tissues expressing at least one of the subunits 5-HT3C, -D, and -E. Furthermore, immunocytochemical studies on transfected mammalian cells revealed co-localization in the endoplasmic reticulum and direct interaction of RIC-3 with 5-HT3A, -C, -D, and -E. F ... | ||
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