Association of a lifestyle score with cardiometabolic markers among individuals with diabetes: a cross-sectional study
Introduction To investigate the associations of a lifestyle score with various cardiovascular risk markers, indicators for fatty liver disease as well as MRI-determined total, subcutaneous and visceral adipose tissue mass in adults with new-onset diabetes. - Research design and methods This cross-se...
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| Hauptverfasser: | , , , , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2023
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| In: |
BMJ Open Diabetes Research & Care
Year: 2023, Jahrgang: 11, Heft: 4, Pages: 1-11 |
| ISSN: | 2052-4897 |
| DOI: | 10.1136/bmjdrc-2023-003469 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1136/bmjdrc-2023-003469 Verlag, kostenfrei, Volltext: https://drc.bmj.com/content/11/4/e003469 
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| Verfasserangaben: | Christina Baechle, Alexander Lang, Klaus Strassburger, Oliver Kuss, Volker Burkart, Julia Szendroedi, Karsten Müssig, Katharina Susanne Weber, Vera Schrauwen-Hinderling, Christian Herder, Michael Roden, Sabrina Schlesinger |
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| 245 | 1 | 0 | |a Association of a lifestyle score with cardiometabolic markers among individuals with diabetes |b a cross-sectional study |c Christina Baechle, Alexander Lang, Klaus Strassburger, Oliver Kuss, Volker Burkart, Julia Szendroedi, Karsten Müssig, Katharina Susanne Weber, Vera Schrauwen-Hinderling, Christian Herder, Michael Roden, Sabrina Schlesinger |
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| 520 | |a Introduction To investigate the associations of a lifestyle score with various cardiovascular risk markers, indicators for fatty liver disease as well as MRI-determined total, subcutaneous and visceral adipose tissue mass in adults with new-onset diabetes. - Research design and methods This cross-sectional analysis included 196 individuals with type 1 (median age: 35 years; median body mass index (BMI): 24 kg/m²) and 272 with type 2 diabetes (median age: 53 years; median BMI: 31 kg/m²) from the German Diabetes Study. A healthy lifestyle score was generated based on healthy diet, moderate alcohol consumption, recreational activity, non-smoking and non-obese BMI. These factors were summed to form a score ranging from 0 to 5. Multivariable linear and non-linear regression models were used. - Results In total, 8.1% of the individuals adhered to none or one, 17.7% to two, 29.7% to three, 26.7% to four, and 17.7% to all five favorable lifestyle factors. High compared with low adherence to the lifestyle score was associated with more favorable outcome measures, including triglycerides (β (95% CI) −49.1 mg/dL (−76.7; −21.4)), low-density lipoprotein (−16.7 mg/dL (−31.3; −2.0)), and high-density lipoprotein cholesterol (13.5 mg/dL (7.6; 19.4)), glycated hemoglobin (−0.5% (−0.8%; −0.1%)), high-sensitivity C reactive protein (−0.4 mg/dL (−0.6; −0.2)), as well as lower hepatic fat content (−8.3% (−11.9%; −4.7%)), and visceral adipose tissue mass (−1.8 dm³ (−2.9; −0.7)). The dose-response analyses showed that adherence to every additional healthy lifestyle factor was associated with more beneficial risk profiles. - Conclusions Adherence to each additional healthy lifestyle factor was beneficially associated with cardiovascular risk markers, indicators of fatty liver disease and adipose tissue mass. Strongest associations were observed for adherence to all healthy lifestyle factors in combination. - Trial registration number NCT01055093. | ||
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