Loss of TAZ after YAP deletion severely impairs foregut development and worsens cholestatic hepatocellular injury
We previously showed that loss of yes-associated protein 1 (YAP) in early liver development (YAPKO) leads to an Alagille syndrome-like phenotype, with failure of intrahepatic bile duct development, severe cholestasis, and chronic hepatocyte adaptations to reduce liver injury. TAZ, a paralog of YAP,...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2023
|
| In: |
Hepatology communications
Year: 2023, Jahrgang: 7, Heft: 9, Pages: 1-13 |
| ISSN: | 2471-254X |
| DOI: | 10.1097/HC9.0000000000000220 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://dx.doi.org/10.1097/HC9.0000000000000220 Verlag, kostenfrei, Volltext: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10412434/ 
|
| Verfasserangaben: | Adelya Gabdulkhakova, Yekaterina Krutsenko, Junjie Zhu, Silvia Liu, Minakshi Poddar, Sucha Singh, Xiaochao Ma, Kari Nejak-Bowen, Satdarshan P.S. Monga, Laura M. Molina |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 186080442X | ||
| 003 | DE-627 | ||
| 005 | 20251112171136.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231005s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1097/HC9.0000000000000220 |2 doi | |
| 035 | |a (DE-627)186080442X | ||
| 035 | |a (DE-599)KXP186080442X | ||
| 035 | |a (OCoLC)1425210856 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Gabdulkhakova, Adelya |d 1994- |e VerfasserIn |0 (DE-588)1305006909 |0 (DE-627)186080652X |4 aut | |
| 245 | 1 | 0 | |a Loss of TAZ after YAP deletion severely impairs foregut development and worsens cholestatic hepatocellular injury |c Adelya Gabdulkhakova, Yekaterina Krutsenko, Junjie Zhu, Silvia Liu, Minakshi Poddar, Sucha Singh, Xiaochao Ma, Kari Nejak-Bowen, Satdarshan P.S. Monga, Laura M. Molina |
| 264 | 1 | |c 2023 | |
| 300 | |b Illustrationen | ||
| 300 | |a 13 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 05.10.2023 | ||
| 520 | |a We previously showed that loss of yes-associated protein 1 (YAP) in early liver development (YAPKO) leads to an Alagille syndrome-like phenotype, with failure of intrahepatic bile duct development, severe cholestasis, and chronic hepatocyte adaptations to reduce liver injury. TAZ, a paralog of YAP, was significantly upregulated in YAPKO hepatocytes and interacted with TEA domain family member (TEAD) transcription factors, suggesting possible compensatory activity., | ||
| 700 | 1 | |a Krutsenko, Yekaterina |e VerfasserIn |4 aut | |
| 700 | 1 | |a Zhu, Junjie |e VerfasserIn |4 aut | |
| 700 | 1 | |a Liu, Silvia |e VerfasserIn |4 aut | |
| 700 | 1 | |a Poddar, Minakshi |e VerfasserIn |4 aut | |
| 700 | 1 | |a Singh, Sucha |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ma, Xiaochao |e VerfasserIn |4 aut | |
| 700 | 1 | |a Nejak-Bowen, Kari |e VerfasserIn |4 aut | |
| 700 | 1 | |a Monga, Satdarshan P.S. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Molina-Molina, Laura |d 1988- |e VerfasserIn |0 (DE-588)1200369343 |0 (DE-627)168334510X |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Hepatology communications |d [Alphen aan den Rijn] : Wolters Kluwer Health, 2017 |g 7(2023), 9, Artikel-ID e0220, Seite 1-13 |h Online-Ressource |w (DE-627)877444587 |w (DE-600)2881134-3 |w (DE-576)482132256 |x 2471-254X |7 nnas |a Loss of TAZ after YAP deletion severely impairs foregut development and worsens cholestatic hepatocellular injury |
| 773 | 1 | 8 | |g volume:7 |g year:2023 |g number:9 |g elocationid:e0220 |g pages:1-13 |g extent:13 |a Loss of TAZ after YAP deletion severely impairs foregut development and worsens cholestatic hepatocellular injury |
| 856 | 4 | 0 | |u https://dx.doi.org/10.1097/HC9.0000000000000220 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10412434/ |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20231005 | ||
| 993 | |a Article | ||
| 994 | |a 2023 | ||
| 998 | |g 1305006909 |a Gabdulkhakova, Adelya |m 1305006909:Gabdulkhakova, Adelya |d 910000 |d 910100 |e 910000PG1305006909 |e 910100PG1305006909 |k 0/910000/ |k 1/910000/910100/ |p 1 |x j | ||
| 999 | |a KXP-PPN186080442X |e 4381595742 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"family":"Gabdulkhakova","given":"Adelya","display":"Gabdulkhakova, Adelya","roleDisplay":"VerfasserIn","role":"aut"},{"display":"Krutsenko, Yekaterina","roleDisplay":"VerfasserIn","role":"aut","family":"Krutsenko","given":"Yekaterina"},{"role":"aut","display":"Zhu, Junjie","roleDisplay":"VerfasserIn","given":"Junjie","family":"Zhu"},{"display":"Liu, Silvia","roleDisplay":"VerfasserIn","role":"aut","family":"Liu","given":"Silvia"},{"given":"Minakshi","family":"Poddar","role":"aut","display":"Poddar, Minakshi","roleDisplay":"VerfasserIn"},{"family":"Singh","given":"Sucha","roleDisplay":"VerfasserIn","display":"Singh, Sucha","role":"aut"},{"display":"Ma, Xiaochao","roleDisplay":"VerfasserIn","role":"aut","family":"Ma","given":"Xiaochao"},{"role":"aut","display":"Nejak-Bowen, Kari","roleDisplay":"VerfasserIn","given":"Kari","family":"Nejak-Bowen"},{"family":"Monga","given":"Satdarshan P.S.","display":"Monga, Satdarshan P.S.","roleDisplay":"VerfasserIn","role":"aut"},{"family":"Molina-Molina","given":"Laura","display":"Molina-Molina, Laura","roleDisplay":"VerfasserIn","role":"aut"}],"title":[{"title":"Loss of TAZ after YAP deletion severely impairs foregut development and worsens cholestatic hepatocellular injury","title_sort":"Loss of TAZ after YAP deletion severely impairs foregut development and worsens cholestatic hepatocellular injury"}],"note":["Gesehen am 05.10.2023"],"type":{"media":"Online-Ressource","bibl":"article-journal"},"recId":"186080442X","language":["eng"],"name":{"displayForm":["Adelya Gabdulkhakova, Yekaterina Krutsenko, Junjie Zhu, Silvia Liu, Minakshi Poddar, Sucha Singh, Xiaochao Ma, Kari Nejak-Bowen, Satdarshan P.S. Monga, Laura M. Molina"]},"origin":[{"dateIssuedKey":"2023","dateIssuedDisp":"2023"}],"id":{"doi":["10.1097/HC9.0000000000000220"],"eki":["186080442X"]},"physDesc":[{"extent":"13 S.","noteIll":"Illustrationen"}],"relHost":[{"name":{"displayForm":["American Association for the Study of Liver Diseases"]},"origin":[{"publisherPlace":"[Alphen aan den Rijn] ; Hoboken, NJ","dateIssuedDisp":"2017-","publisher":"Wolters Kluwer Health ; Wiley","dateIssuedKey":"2017"}],"id":{"zdb":["2881134-3"],"eki":["877444587"],"issn":["2471-254X"]},"physDesc":[{"extent":"Online-Ressource"}],"title":[{"title":"Hepatology communications","title_sort":"Hepatology communications"}],"disp":"Loss of TAZ after YAP deletion severely impairs foregut development and worsens cholestatic hepatocellular injuryHepatology communications","type":{"media":"Online-Ressource","bibl":"periodical"},"note":["Gesehen am 19.01.23"],"recId":"877444587","language":["eng"],"corporate":[{"role":"isb","roleDisplay":"Herausgebendes Organ","display":"American Association for the Study of Liver Diseases"}],"pubHistory":["Volume 1, Issue 1 (2017)-"],"part":{"extent":"13","text":"7(2023), 9, Artikel-ID e0220, Seite 1-13","volume":"7","pages":"1-13","issue":"9","year":"2023"}}]} | ||
| SRT | |a GABDULKHAKLOSSOFTAZA2023 | ||