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Influence of depression symptoms on serum tumor necrosis factor-α of patients with chronic low back pain

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Patients with chronic low back pain (cLBP) have high rates of comorbid psychiatric disorders, mainly depression. Recent evidence suggests that depressive symptoms and pain, as interacting factors, have an effect on the circulating levels of inflammatory markers relevant to coronary artery disease. O...

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Main Authors: Wang, Haili (Author) , Ahrens, Carsten (Author) , Rief, Winfried (Author) , Gantz, Simone (Author) , Schiltenwolf, Marcus (Author) , Richter, Wiltrud (Author)
Format: Article (Journal)
Language:English
Published: 11 October 2010
In: Arthritis Research & Therapy
Year: 2010, Volume: 12, Issue: 5, Pages: 1-7
ISSN:1465-9913
DOI:10.1186/ar3156
Online Access:Resolving-System, kostenfrei, Volltext: https://doi.org/10.1186/ar3156
Verlag, kostenfrei, Volltext: https://arthritis-research.biomedcentral.com/articles/10.1186/ar3156
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Author Notes:Haili Wang, Carsten Ahrens, Winfried Rief, Simone Gantz, Marcus Schiltenwolf, Wiltrud Richter
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Summary:Patients with chronic low back pain (cLBP) have high rates of comorbid psychiatric disorders, mainly depression. Recent evidence suggests that depressive symptoms and pain, as interacting factors, have an effect on the circulating levels of inflammatory markers relevant to coronary artery disease. Our previous work showed a higher serum level of an inflammatory marker tumour necrosis factor-alpha (TNFα) in patients with cLBP, which did not correlate with intensity of low back pain alone. In the present study we investigated the cross-sectional associations of depressive symptoms, low back pain and their interaction with circulating levels of TNFα.
Item Description:Gesehen am 10.10.2023
Physical Description:Online Resource
ISSN:1465-9913
DOI:10.1186/ar3156

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