MicroRNA networks linked with BRCA1/2, PTEN, and common genes for Alzheimer's disease and breast cancer share highly enriched pathways that may unravel targets for the AD/BC comorbidity treatment
MicroRNAs (miRNAs) are involved in the regulation of various cellular processes including pathological conditions. MiRNA networks have been extensively researched in age-related degenerative diseases, such as cancer, Alzheimer's disease (AD), and heart failure. Thus, miRNA has been studied from...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
October 2023
|
| In: |
Computational biology and chemistry
Year: 2023, Jahrgang: 106, Pages: 1-13 |
| DOI: | 10.1016/j.compbiolchem.2023.107925 |
| Online-Zugang: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.compbiolchem.2023.107925 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S1476927123001160 
|
| Verfasserangaben: | Nina Petrović, Magbubah Essack, Ahmad Šami, George Perry, Takashi Gojobori, Esma R. Isenović, Vladan P. Bajić |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1861507178 | ||
| 003 | DE-627 | ||
| 005 | 20240307051211.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231011s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1016/j.compbiolchem.2023.107925 |2 doi | |
| 035 | |a (DE-627)1861507178 | ||
| 035 | |a (DE-599)KXP1861507178 | ||
| 035 | |a (OCoLC)1425210582 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Petrović, Nina |e VerfasserIn |0 (DE-588)129980456X |0 (DE-627)1856823873 |4 aut | |
| 245 | 1 | 0 | |a MicroRNA networks linked with BRCA1/2, PTEN, and common genes for Alzheimer's disease and breast cancer share highly enriched pathways that may unravel targets for the AD/BC comorbidity treatment |c Nina Petrović, Magbubah Essack, Ahmad Šami, George Perry, Takashi Gojobori, Esma R. Isenović, Vladan P. Bajić |
| 246 | 3 | 0 | |a one two |
| 264 | 1 | |c October 2023 | |
| 300 | |a 13 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Online veröffentlicht: 16. Juli 2023 | ||
| 500 | |a Gesehen am 11.10.2023 | ||
| 520 | |a MicroRNAs (miRNAs) are involved in the regulation of various cellular processes including pathological conditions. MiRNA networks have been extensively researched in age-related degenerative diseases, such as cancer, Alzheimer's disease (AD), and heart failure. Thus, miRNA has been studied from different approaches, in vivo, in vitro, and in silico including miRNA networks. Networks linking diverse biomedical entities unveil information not readily observable by other means. This work focuses on biological networks related to Breast cancer susceptibility 1 (BRCA1) in AD and breast cancer (BC). Using various bioinformatics approaches, we identified subnetworks common to AD and BC that suggest they are linked. According to our results, miR-107 was identified as a potentially good candidate for both AD and BC treatment (targeting BRCA1/2 and PTEN in both diseases), accompanied by miR-146a and miR-17. The analysis also confirmed the involvement of the miR-17-92 cluster, and miR-124-3p, and highlighted the importance of poorly researched miRNAs such as mir-6785 mir-6127, mir-6870, or miR-8485. After filtering the in silico analysis results, we found 49 miRNA molecules that modulate the expression of at least five genes common to both BC and AD. Those 49 miRNAs regulate the expression of 122 genes in AD and 93 genes in BC, from which 26 genes are common genes for AD and BC involved in neuron differentiation and genesis, cell differentiation and migration, regulation of cell cycle, and cancer development. Additionally, the highly enriched pathway was associated with diabetic complications, pointing out possible interplay among molecules underlying BC, AD, and diabetes pathology. | ||
| 650 | 4 | |a Alzheimer's disease | |
| 650 | 4 | |a BRCA1/2 | |
| 650 | 4 | |a Breast cancer | |
| 650 | 4 | |a MicroRNA | |
| 650 | 4 | |a PTEN | |
| 700 | 1 | |a Essack, Magbubah |e VerfasserIn |4 aut | |
| 700 | 1 | |a Šami, Ahmad |d 1987- |e VerfasserIn |0 (DE-588)1230516158 |0 (DE-627)1752986636 |4 aut | |
| 700 | 1 | |a Perry, George |e VerfasserIn |4 aut | |
| 700 | 1 | |a Gojobori, Takashi |e VerfasserIn |4 aut | |
| 700 | 1 | |a Isenović, Esma R. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Bajić, Vladan P. |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Computational biology and chemistry |d Oxford : Elsevier Science, 2003 |g 106(2023) vom: Okt., Artikel-ID 107925, Seite 1-13 |h Online-Ressource |w (DE-627)36446755X |w (DE-600)2110171-1 |w (DE-576)106802054 |7 nnas |a MicroRNA networks linked with BRCA1/2, PTEN, and common genes for Alzheimer's disease and breast cancer share highly enriched pathways that may unravel targets for the AD/BC comorbidity treatment |
| 773 | 1 | 8 | |g volume:106 |g year:2023 |g month:10 |g elocationid:107925 |g pages:1-13 |g extent:13 |a MicroRNA networks linked with BRCA1/2, PTEN, and common genes for Alzheimer's disease and breast cancer share highly enriched pathways that may unravel targets for the AD/BC comorbidity treatment |
| 856 | 4 | 0 | |u https://doi.org/10.1016/j.compbiolchem.2023.107925 |x Verlag |x Resolving-System |z lizenzpflichtig |3 Volltext |
| 856 | 4 | 0 | |u https://www.sciencedirect.com/science/article/pii/S1476927123001160 |x Verlag |z lizenzpflichtig |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20231011 | ||
| 993 | |a Article | ||
| 994 | |a 2023 | ||
| 998 | |g 1230516158 |a Šami, Ahmad |m 1230516158:Šami, Ahmad |d 60000 |d 63000 |e 60000PS1230516158 |e 63000PS1230516158 |k 0/60000/ |k 1/60000/63000/ |p 3 | ||
| 999 | |a KXP-PPN1861507178 |e 438389190X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"person":[{"family":"Petrović","display":"Petrović, Nina","given":"Nina","role":"aut"},{"display":"Essack, Magbubah","family":"Essack","role":"aut","given":"Magbubah"},{"role":"aut","given":"Ahmad","display":"Šami, Ahmad","family":"Šami"},{"given":"George","role":"aut","display":"Perry, George","family":"Perry"},{"role":"aut","given":"Takashi","family":"Gojobori","display":"Gojobori, Takashi"},{"display":"Isenović, Esma R.","family":"Isenović","given":"Esma R.","role":"aut"},{"role":"aut","given":"Vladan P.","display":"Bajić, Vladan P.","family":"Bajić"}],"origin":[{"dateIssuedDisp":"October 2023","dateIssuedKey":"2023"}],"note":["Online veröffentlicht: 16. Juli 2023","Gesehen am 11.10.2023"],"type":{"bibl":"article-journal","media":"Online-Ressource"},"title":[{"title":"MicroRNA networks linked with BRCA1/2, PTEN, and common genes for Alzheimer's disease and breast cancer share highly enriched pathways that may unravel targets for the AD/BC comorbidity treatment","title_sort":"MicroRNA networks linked with BRCA1/2, PTEN, and common genes for Alzheimer's disease and breast cancer share highly enriched pathways that may unravel targets for the AD/BC comorbidity treatment"}],"language":["eng"],"name":{"displayForm":["Nina Petrović, Magbubah Essack, Ahmad Šami, George Perry, Takashi Gojobori, Esma R. Isenović, Vladan P. Bajić"]},"physDesc":[{"extent":"13 S."}],"recId":"1861507178","relHost":[{"recId":"36446755X","pubHistory":["27.2003 - 35.2011; Vol. 36.2012 -"],"physDesc":[{"extent":"Online-Ressource"}],"id":{"eki":["36446755X"],"zdb":["2110171-1"]},"disp":"MicroRNA networks linked with BRCA1/2, PTEN, and common genes for Alzheimer's disease and breast cancer share highly enriched pathways that may unravel targets for the AD/BC comorbidity treatmentComputational biology and chemistry","language":["eng"],"part":{"volume":"106","extent":"13","text":"106(2023) vom: Okt., Artikel-ID 107925, Seite 1-13","pages":"1-13","year":"2023"},"origin":[{"publisherPlace":"Oxford","dateIssuedDisp":"2003-","publisher":"Elsevier Science","dateIssuedKey":"2003"}],"note":["Gesehen am 09.02.2021"],"type":{"bibl":"periodical","media":"Online-Ressource"},"titleAlt":[{"title":"CBAC"}],"title":[{"title":"Computational biology and chemistry","title_sort":"Computational biology and chemistry","subtitle":"CBAC"}]}],"id":{"eki":["1861507178"],"doi":["10.1016/j.compbiolchem.2023.107925"]}} | ||
| SRT | |a PETROVICNIMICRORNANE2023 | ||