Tumour mutational burden and survival with molecularly matched therapy

The impact of tumour mutational burden (TMB) on outcome with molecularly matched therapy is unknown. Higher TMB could predict resistance to molecularly matched therapy through co-occurring driver mutations.

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Bibliographic Details
Main Authors:	De Bortoli, Till (Author) , Benary, Manuela (Author) , Horak, Peter (Author) , Lamping, Mario (Author) , Stintzing, Sebastian (Author) , Tinhofer, Ingeborg (Author) , Leyvraz, Serge (Author) , Schäfer, Reinhold (Author) , Klauschen, Frederick (Author) , Keller, Ulrich (Author) , Stenzinger, Albrecht (Author) , Fröhling, Stefan (Author) , Kurzrock, Razelle (Author) , Keilholz, Ulrich (Author) , Rieke, Damian (Author) , Jelas, Ivan (Author)
Format:	Article (Journal)
Language:	English
Published:	September 2023
In:	European journal of cancer Year: 2023, Volume: 190, Pages: 1-10
ISSN:	1879-0852
DOI:	10.1016/j.ejca.2023.05.013
Online Access:	Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.ejca.2023.05.013 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0959804923002538
Author Notes:	Till de Bortoli, Manuela Benary, Peter Horak, Mario Lamping, Sebastian Stintzing, Ingeborg Tinhofer, Serge Leyvraz, Reinhold Schäfer, Frederick Klauschen, Ulrich Keller, Albrecht Stenzinger, Stefan Fröhling, Razelle Kurzrock, Ulrich Keilholz, Damian T. Rieke, Ivan Jelas

Description
Summary:	The impact of tumour mutational burden (TMB) on outcome with molecularly matched therapy is unknown. Higher TMB could predict resistance to molecularly matched therapy through co-occurring driver mutations.
Item Description:	Online veröffentlicht am 4. August 2023 Gesehen am 12.12.2023
Physical Description:	Online Resource
ISSN:	1879-0852
DOI:	10.1016/j.ejca.2023.05.013