Genetic ablation of ketohexokinase C isoform impairs pancreatic cancer development

Although dietary fructose is associated with an elevated risk for pancreatic cancer, the underlying mechanisms remain elusive. Here, we report that ketohexokinase (KHK), the rate-limiting enzyme of fructose metabolism, is a driver of PDAC development. We demonstrate that fructose triggers KHK and in...

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Bibliographic Details

Main Authors:	Guccini, Ilaria (Author) , Tang, Guanghui (Author) , To, Trang Thuy (Author) , Di Rito, Laura (Author) , Le Blanc, Solange (Author) , Strobel, Oliver (Author) , D’Ambrosio, Mariantonietta (Author) , Pasquini, Emiliano (Author) , Bolis, Marco (Author) , Silva, Pamuditha (Author) , Kabakci, Hasan Ali (Author) , Godbersen, Svenja (Author) , Alimonti, Andrea (Author) , Schwank, Gerald (Author) , Stoffel, Markus (Author)
Format:	Article (Journal)
Language:	English
Published:	18 August 2023
In:	iScience Year: 2023, Volume: 26, Issue: 8, Pages: 1-29
ISSN:	2589-0042
DOI:	10.1016/j.isci.2023.107368
Online Access:	Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.isci.2023.107368 Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S2589004223014451
Author Notes:	Ilaria Guccini, Guanghui Tang, Trang Thuy To, Laura Di Rito, Solange Le Blanc, Oliver Strobel, Mariantonietta D’Ambrosio, Emiliano Pasquini, Marco Bolis, Pamuditha Silva, Hasan Ali Kabakci, Svenja Godbersen, Andrea Alimonti, Gerald Schwank, and Markus Stoffel