Genetic ablation of ketohexokinase C isoform impairs pancreatic cancer development
Although dietary fructose is associated with an elevated risk for pancreatic cancer, the underlying mechanisms remain elusive. Here, we report that ketohexokinase (KHK), the rate-limiting enzyme of fructose metabolism, is a driver of PDAC development. We demonstrate that fructose triggers KHK and in...
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| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
18 August 2023
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| In: |
iScience
Year: 2023, Volume: 26, Issue: 8, Pages: 1-29 |
| ISSN: | 2589-0042 |
| DOI: | 10.1016/j.isci.2023.107368 |
| Online Access: | Verlag, kostenfrei, Volltext: https://doi.org/10.1016/j.isci.2023.107368 Verlag, kostenfrei, Volltext: https://www.sciencedirect.com/science/article/pii/S2589004223014451 
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| Author Notes: | Ilaria Guccini, Guanghui Tang, Trang Thuy To, Laura Di Rito, Solange Le Blanc, Oliver Strobel, Mariantonietta D’Ambrosio, Emiliano Pasquini, Marco Bolis, Pamuditha Silva, Hasan Ali Kabakci, Svenja Godbersen, Andrea Alimonti, Gerald Schwank, and Markus Stoffel |
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| 520 | |a Although dietary fructose is associated with an elevated risk for pancreatic cancer, the underlying mechanisms remain elusive. Here, we report that ketohexokinase (KHK), the rate-limiting enzyme of fructose metabolism, is a driver of PDAC development. We demonstrate that fructose triggers KHK and induces fructolytic gene expression in mouse and human PDAC. ... | ||
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