Interaction of angiotensin receptor type 1 blockers with ATP-binding cassette transporters
ATP-binding cassette (ABC)-transporters, such as P-glycoprotein (P-gp/ABCB1), multidrug resistance-associated proteins (MRPs/ABCCs) and breast cancer resistance protein (BCRP/ABCG2) transport numerous drugs thus regulating their absorption, distribution and excretion. Angiotensin receptor type 1 blo...
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| Main Authors: | , , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
10 March 2010
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| In: |
Biopharmaceutics & drug disposition
Year: 2010, Volume: 31, Issue: 2/3, Pages: 150-161 |
| ISSN: | 1099-081X |
| DOI: | 10.1002/bdd.699 |
| Online Access: | Resolving-System, lizenzpflichtig, Volltext: https://doi.org/10.1002/bdd.699 Verlag, lizenzpflichtig, Volltext: https://onlinelibrary.wiley.com/doi/abs/10.1002/bdd.699 |
| Author Notes: | J. Weiss, A. Sauer, N. Divac, M. Herzog, E. Schwedhelm, R.H. Böger, W.E. Haefeli, and R.A. Benndorf |
MARC
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| 245 | 1 | 0 | |a Interaction of angiotensin receptor type 1 blockers with ATP-binding cassette transporters |c J. Weiss, A. Sauer, N. Divac, M. Herzog, E. Schwedhelm, R.H. Böger, W.E. Haefeli, and R.A. Benndorf |
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| 520 | |a ATP-binding cassette (ABC)-transporters, such as P-glycoprotein (P-gp/ABCB1), multidrug resistance-associated proteins (MRPs/ABCCs) and breast cancer resistance protein (BCRP/ABCG2) transport numerous drugs thus regulating their absorption, distribution and excretion. Angiotensin receptor type 1 blockers (ARBs), used to treat hypertension and heart failure, are commonly administered in combination therapy. However, their interaction potential is not well studied and their effect on ABC-transporters remains elusive. The study therefore aimed to elucidate the effect of various ARBs (telmisartan, candesartan, candesartan-cilexetil, irbesartan, losartan, olmesartan, olmesartan-medoxomil, eprosartan) on ABC-transporter activity in vitro... | ||
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