Impact of age on endothelial function of saphenous vein grafts in coronary artery bypass grafting
Background: An intact and functionally preserved endothelial layer in the graft is crucial for myocardial perfusion and graft patency after coronary artery bypass grafting (CABG). We hypothesized that old age is a risk factor for decreased endothelial function of bypass grafts. Thus, we investigated...
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| Hauptverfasser: | , , , , , , , , |
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| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2023
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| In: |
Journal of Clinical Medicine
Year: 2023, Jahrgang: 12, Heft: 17, Pages: 1-17 |
| ISSN: | 2077-0383 |
| DOI: | 10.3390/jcm12175454 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.3390/jcm12175454 Verlag, kostenfrei, Volltext: https://www.mdpi.com/2077-0383/12/17/5454 
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| Verfasserangaben: | Lars Saemann, Lena Wernstedt, Sabine Pohl, Markus Stiller, Jan Willsch, Britt Hofmann, Gábor Veres, Andreas Simm and Gábor Szabó |
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| 245 | 1 | 0 | |a Impact of age on endothelial function of saphenous vein grafts in coronary artery bypass grafting |c Lars Saemann, Lena Wernstedt, Sabine Pohl, Markus Stiller, Jan Willsch, Britt Hofmann, Gábor Veres, Andreas Simm and Gábor Szabó |
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| 520 | |a Background: An intact and functionally preserved endothelial layer in the graft is crucial for myocardial perfusion and graft patency after coronary artery bypass grafting (CABG). We hypothesized that old age is a risk factor for decreased endothelial function of bypass grafts. Thus, we investigated the impact of age in patients treated with CABG on endothelial function in saphenous vein grafts. Methods: We mounted the saphenous vein graft segments of CABG patients < 70 (n = 33) and ≥70 (n = 40) years of age in organ bath chambers and exposed them to potassium chloride (KCl) and phenylephrine (PE) to test the receptor-independent and -dependent contractility, followed by exposure to acetylcholine (ACh) and sodium nitroprusside (SNP) to test the endothelial-dependent and -independent relaxation. Results: The maximal contraction induced by KCl (2.3 ± 1.8 vs. 1.8 ± 2 g) was stronger in patients ≥ 70 years of age. The relative contraction induced by PE in % of KCl (167 ± 64 vs. 163 ± 59%) was similar between groups. Patients aged < 70 years showed a higher endothelial-dependent relaxation induced by acetylcholine than patients ≥ 70 years (51 ± 27 vs. 42 ± 18%). The relaxation induced by SNP was similar between both groups. Conclusions: The endothelial function of saphenous vein bypass grafts decreases during aging. Thus, age should be considered when improving graft maintenance. | ||
| 650 | 4 | |a aging | |
| 650 | 4 | |a coronary artery bypass grafting (CABG) | |
| 650 | 4 | |a coronary artery disease | |
| 650 | 4 | |a endothelium | |
| 650 | 4 | |a saphenous vein | |
| 650 | 4 | |a senescence | |
| 700 | 1 | |a Wernstedt, Lena |e VerfasserIn |4 aut | |
| 700 | 1 | |a Pohl, Sabine |e VerfasserIn |4 aut | |
| 700 | 1 | |a Stiller, Markus |e VerfasserIn |4 aut | |
| 700 | 1 | |a Willsch, Jan |e VerfasserIn |4 aut | |
| 700 | 1 | |a Hofmann, Britt |e VerfasserIn |4 aut | |
| 700 | 1 | |a Veres, Gábor |e VerfasserIn |4 aut | |
| 700 | 1 | |a Simm, Andreas |e VerfasserIn |4 aut | |
| 700 | 1 | |a Szabó, Gábor |d 1969- |e VerfasserIn |0 (DE-588)1022955152 |0 (DE-627)717338681 |0 (DE-576)366215485 |4 aut | |
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