Digit ratio (2D:4D) is not associated with Alzheimer’s disease in the elderly
The development of Alzheimer’s disease (AD) is influenced by sex hormones—estrogens and androgens in particular. However, the impact of prenatal sex hormone exposure is less clear; very few investigations have examined the relationship between the second-to-fourth digit length ratio (2D:4D), a putat...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
2023
|
| In: |
Brain Sciences
Year: 2023, Jahrgang: 13, Heft: 9, Pages: 1-13 |
| ISSN: | 2076-3425 |
| DOI: | 10.3390/brainsci13091229 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.3390/brainsci13091229 Verlag, kostenfrei, Volltext: https://www.mdpi.com/2076-3425/13/9/1229 
|
| Verfasserangaben: | Eva-Maria Siegmann, Pauline Olm, Bernd Lenz, Christiane Mühle, Timo Jan Oberstein, Juan Manuel Maler and Johannes Kornhuber |
MARC
| LEADER | 00000caa a2200000 c 4500 | ||
|---|---|---|---|
| 001 | 1868105857 | ||
| 003 | DE-627 | ||
| 005 | 20240307044419.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231026s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.3390/brainsci13091229 |2 doi | |
| 035 | |a (DE-627)1868105857 | ||
| 035 | |a (DE-599)KXP1868105857 | ||
| 035 | |a (OCoLC)1425210094 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 33 |2 sdnb | ||
| 100 | 1 | |a Siegmann, Eva-Maria |e VerfasserIn |0 (DE-588)1296838366 |0 (DE-627)1853249696 |4 aut | |
| 245 | 1 | 0 | |a Digit ratio (2D:4D) is not associated with Alzheimer’s disease in the elderly |c Eva-Maria Siegmann, Pauline Olm, Bernd Lenz, Christiane Mühle, Timo Jan Oberstein, Juan Manuel Maler and Johannes Kornhuber |
| 264 | 1 | |c 2023 | |
| 300 | |b Illustrationen | ||
| 300 | |a 13 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Veröffentlicht: 22. August 2023 | ||
| 500 | |a Gesehen am 26.10.2023 | ||
| 520 | |a The development of Alzheimer’s disease (AD) is influenced by sex hormones—estrogens and androgens in particular. However, the impact of prenatal sex hormone exposure is less clear; very few investigations have examined the relationship between the second-to-fourth digit length ratio (2D:4D), a putative proxy for the ratio of prenatal estrogens to androgens, and AD, with inconsistent results among the few that have. Therefore, we aimed to investigate this relationship using methodologically robust metrics. In a 2 (sex) × 4 (group) MANOVA incorporating 108 participants (30 AD patients, 19 patients with tauopathy but no amyloidopathy, 31 clinical and 28 healthy age- and education-matched controls), the effects of sex and group on the dependent variables right and left 2D:4D were examined. We also explored the association between 2D:4D and the severity of AD symptoms assessed via neuropsychological examination. We did not find any significant differences in the right- and left-hand 2D:4D between patients with AD and the other groups; no significant associations between 2D:4D and neuropsychological task performances were found in the dementia groups. The 2D:4D of healthy women was significantly lower than that of depressed women without AD, i.e., clinical controls, but not significantly different from depressed female patients with AD. This investigation does not support the role of 2D:4D in the development or severity of AD in general, but suggests a potential role of 2D:4D for depression in women. Future studies are warranted to clarify whether 2D:4D can distinguish between early- and late-onset depression in women. | ||
| 650 | 4 | |a Alzheimer’s disease | |
| 650 | 4 | |a dementia | |
| 650 | 4 | |a digit ratio | |
| 650 | 4 | |a fetal development | |
| 650 | 4 | |a finger length ratio | |
| 700 | 1 | |a Olm, Pauline |e VerfasserIn |4 aut | |
| 700 | 1 | |a Lenz, Bernd |d 1981- |e VerfasserIn |0 (DE-588)134116151 |0 (DE-627)560889518 |0 (DE-576)300322070 |4 aut | |
| 700 | 1 | |a Mühle, Christiane |e VerfasserIn |4 aut | |
| 700 | 1 | |a Oberstein, Timo Jan |e VerfasserIn |4 aut | |
| 700 | 1 | |a Maler, Juan Manuel |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kornhuber, Johannes |e VerfasserIn |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Brain Sciences |d Basel : MDPI AG, 2011 |g 13(2023), 9, Artikel-ID 1229, Seite 1-13 |h Online-Ressource |w (DE-627)687718139 |w (DE-600)2651993-8 |w (DE-576)360029442 |x 2076-3425 |7 nnas |a Digit ratio (2D:4D) is not associated with Alzheimer’s disease in the elderly |
| 773 | 1 | 8 | |g volume:13 |g year:2023 |g number:9 |g elocationid:1229 |g pages:1-13 |g extent:13 |a Digit ratio (2D:4D) is not associated with Alzheimer’s disease in the elderly |
| 856 | 4 | 0 | |u https://doi.org/10.3390/brainsci13091229 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.mdpi.com/2076-3425/13/9/1229 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20231026 | ||
| 993 | |a Article | ||
| 994 | |a 2023 | ||
| 998 | |g 134116151 |a Lenz, Bernd |m 134116151:Lenz, Bernd |d 60000 |e 60000PL134116151 |k 0/60000/ |p 3 | ||
| 999 | |a KXP-PPN1868105857 |e 439809315X | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"origin":[{"dateIssuedKey":"2023","dateIssuedDisp":"2023"}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"person":[{"role":"aut","family":"Siegmann","given":"Eva-Maria","display":"Siegmann, Eva-Maria"},{"display":"Olm, Pauline","family":"Olm","given":"Pauline","role":"aut"},{"role":"aut","given":"Bernd","family":"Lenz","display":"Lenz, Bernd"},{"given":"Christiane","family":"Mühle","display":"Mühle, Christiane","role":"aut"},{"role":"aut","family":"Oberstein","given":"Timo Jan","display":"Oberstein, Timo Jan"},{"role":"aut","display":"Maler, Juan Manuel","family":"Maler","given":"Juan Manuel"},{"display":"Kornhuber, Johannes","given":"Johannes","family":"Kornhuber","role":"aut"}],"title":[{"title":"Digit ratio (2D:4D) is not associated with Alzheimer’s disease in the elderly","title_sort":"Digit ratio (2D:4D) is not associated with Alzheimer’s disease in the elderly"}],"note":["Veröffentlicht: 22. August 2023","Gesehen am 26.10.2023"],"relHost":[{"language":["eng"],"part":{"text":"13(2023), 9, Artikel-ID 1229, Seite 1-13","year":"2023","issue":"9","extent":"13","volume":"13","pages":"1-13"},"disp":"Digit ratio (2D:4D) is not associated with Alzheimer’s disease in the elderlyBrain Sciences","physDesc":[{"extent":"Online-Ressource"}],"recId":"687718139","id":{"eki":["687718139"],"zdb":["2651993-8"],"issn":["2076-3425"]},"note":["Gesehen am 01.10.2020"],"type":{"bibl":"periodical","media":"Online-Ressource"},"origin":[{"dateIssuedDisp":"2011-","publisher":"MDPI AG","publisherPlace":"Basel","dateIssuedKey":"2011"}],"pubHistory":["1.2011 -"],"title":[{"title":"Brain Sciences","title_sort":"Brain Sciences"}]}],"name":{"displayForm":["Eva-Maria Siegmann, Pauline Olm, Bernd Lenz, Christiane Mühle, Timo Jan Oberstein, Juan Manuel Maler and Johannes Kornhuber"]},"recId":"1868105857","id":{"doi":["10.3390/brainsci13091229"],"eki":["1868105857"]},"language":["eng"],"physDesc":[{"noteIll":"Illustrationen","extent":"13 S."}]} | ||
| SRT | |a SIEGMANNEVDIGITRATIO2023 | ||