Increased plasma level of soluble P-selectin in non-hospitalized COVID-19 convalescent donors: full length article
Background - The coronavirus disease-2019 (COVID-19) is a systemic disease with severe implications on the vascular and coagulation system. A procoagulant platelet phenotype has been reported at least in the acute disease phase. Soluble P-selectin (sP-sel) in the plasma is a surrogate biomarker of p...
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| Main Authors: | , , , , , , |
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| Format: | Article (Journal) |
| Language: | English |
| Published: |
August 2022
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| In: |
Thrombosis research
Year: 2022, Volume: 216, Pages: 120-124 |
| ISSN: | 1879-2472 |
| DOI: | 10.1016/j.thromres.2022.06.014 |
| Online Access: | Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.thromres.2022.06.014 Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S0049384822003073 
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| Author Notes: | Rebecca Müller, Gabi Rink, Günalp Uzun, Tamam Bakchoul, Patrick Wuchter, Harald Klüter, Peter Bugert |
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| 245 | 1 | 0 | |a Increased plasma level of soluble P-selectin in non-hospitalized COVID-19 convalescent donors |b full length article |c Rebecca Müller, Gabi Rink, Günalp Uzun, Tamam Bakchoul, Patrick Wuchter, Harald Klüter, Peter Bugert |
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| 520 | |a Background - The coronavirus disease-2019 (COVID-19) is a systemic disease with severe implications on the vascular and coagulation system. A procoagulant platelet phenotype has been reported at least in the acute disease phase. Soluble P-selectin (sP-sel) in the plasma is a surrogate biomarker of platelet activation. Increased plasma levels of sP-sel have been reported in hospitalized COVID-19 patients associated with disease severity. Here, we evaluated in a longitudinal study the sP-sel plasma concentration in blood donors who previously suffered from moderate COVID-19. - Methods - 154 COVID-19 convalescent and 111 non-infected control donors were recruited for plasma donation and for participation in the CORE research trial. First donation (T1) was performed 43-378 days after COVID-19 diagnosis. From most of the donors the second (T2) plasma donation including blood sampling was obtained after a time period of 21-74 days and the third (T3) donation after additional 22-78 days. Baseline characteristics including COVID-19 symptoms of the donors were recorded based on a questionnaire. Platelet function was measured at T1 by flow cytometry and light transmission aggregometry in a representative subgroup of 25 COVID-19 convalescent and 28 control donors. The sP-sel plasma concentration was determined in a total of 704 samples by using a commercial ELISA. - Results - In vitro platelet function was comparable in COVID-19 convalescent and control donors at T1. Plasma samples from COVID-19 convalescent donors revealed a significantly higher sP-sel level compared to controls at T1 (1.05 ± 0.42 ng/mL vs. 0.81 ± 0.30 ng/mL; p < 0.0001) and T2 (0.96 ± 0.39 ng/mL vs. 0.83 ± 0.38 ng/mL; p = 0.0098). At T3 the sP-sel plasma level was comparable in both study groups. Most of the COVID-19 convalescent donors showed a continuous decrease of sP-sel from T1 to T3. - Conclusion - Increased sP-sel plasma concentration as a marker for platelet or endothelial activation could be demonstrated even weeks after moderate COVID-19, whereas, in vitro platelet function was comparable with non-infected controls. We conclude that COVID-19 and additional individual factors could lead to an increase of the sP-sel plasma level. | ||
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| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a Plasma marker | |
| 650 | 4 | |a Platelet function | |
| 650 | 4 | |a SARS-CoV-2 infection | |
| 650 | 4 | |a Soluble P-selectin | |
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