Cover Image

Standards of pathology in the diagnosis of systemic mastocytosis: recommendations of the EU-US Cooperative Group

Pathology plays a central role in the diagnosis of systemic mastocytosis (SM), its delineation from other neoplasms and reactive conditions, and in monitoring of SM under therapy. The morphologic hallmark of SM is the accumulation of spindle-shaped, hypogranulated mast cells (MCs) in bone marrow (BM...

Full description

Saved in:
Bibliographic Details
Main Authors: Sotlar, Karl (Author) , George, Tracy I. (Author) , Kluin, Philip (Author) , Reiter, Andreas (Author) , Schwaab, Juliana (Author) , Panse, Jens (Author) , Brockow, Knut (Author) , Hartmann, Karin (Author) , Sperr, Wolfgang R. (Author) , Kristensen, Thomas (Author) , Nedoszytko, Boguslaw (Author) , Carter, Melody (Author) , Bonadonna, Patrizia (Author) , Lyons, Jonathan J. (Author) , Kluin-Nelemans, Hanneke C. (Author) , Hermine, Olivier (Author) , Akin, Cem (Author) , Broesby-Olsen, Sigurd (Author) , Hoermann, Gregor (Author) , Triggiani, Massimo (Author) , Butterfield, Joseph H. (Author) , Jawhar, Mohamad (Author) , Gotlib, Jason (Author) , Metcalfe, Dean D. (Author) , Orfao, Alberto (Author) , Arock, Michel (Author) , Valent, Peter (Author) , Horny, Hans-Peter (Author)
Format: Article (Journal)
Language:English
Published: August 2022
In: The journal of allergy and clinical immunology. In practice
Year: 2022, Volume: 10, Issue: 8, Pages: 1986-1998.e2
ISSN:2213-2201
DOI:10.1016/j.jaip.2022.05.036
Online Access:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1016/j.jaip.2022.05.036
Verlag, lizenzpflichtig, Volltext: https://www.sciencedirect.com/science/article/pii/S2213219822005876
Get full text
Author Notes:Karl Sotlar, Tracy I. George, Philip Kluin, Andreas Reiter, Juliana Schwaab, Jens Panse, Knut Brockow, Karin Hartmann, Wolfgang R. Sperr, Thomas Kristensen, Boguslaw Nedoszytko, Melody Carter, Patrizia Bonadonna, Jonathan J. Lyons, Hanneke C. Kluin-Nelemans, Olivier Hermine, Cem Akin, Sigurd Broesby-Olsen, Gregor Hoermann, Massimo Triggiani, Joseph H. Butterfield, Mohamad Jawhar, Jason Gotlib, Dean D. Metcalfe, Alberto Orfao, Michel Arock, Peter Valent, Hans-Peter Horny

MARC

LEADER 00000caa a22000002c 4500
001 1868862240
003 DE-627
005 20240307082144.0
007 cr uuu---uuuuu
008 231031s2022 xx |||||o 00| ||eng c
024 7 |a 10.1016/j.jaip.2022.05.036  |2 doi 
035 |a (DE-627)1868862240 
035 |a (DE-599)KXP1868862240 
035 |a (OCoLC)1425216569 
040 |a DE-627  |b ger  |c DE-627  |e rda 
041 |a eng 
084 |a 33  |2 sdnb 
100 1 |a Sotlar, Karl  |d 1965-  |e VerfasserIn  |0 (DE-588)114883521  |0 (DE-627)486911292  |0 (DE-576)182530574  |4 aut 
245 1 0 |a Standards of pathology in the diagnosis of systemic mastocytosis: recommendations of the EU-US Cooperative Group  |c Karl Sotlar, Tracy I. George, Philip Kluin, Andreas Reiter, Juliana Schwaab, Jens Panse, Knut Brockow, Karin Hartmann, Wolfgang R. Sperr, Thomas Kristensen, Boguslaw Nedoszytko, Melody Carter, Patrizia Bonadonna, Jonathan J. Lyons, Hanneke C. Kluin-Nelemans, Olivier Hermine, Cem Akin, Sigurd Broesby-Olsen, Gregor Hoermann, Massimo Triggiani, Joseph H. Butterfield, Mohamad Jawhar, Jason Gotlib, Dean D. Metcalfe, Alberto Orfao, Michel Arock, Peter Valent, Hans-Peter Horny 
264 1 |c August 2022 
300 |a 13 
336 |a Text  |b txt  |2 rdacontent 
337 |a Computermedien  |b c  |2 rdamedia 
338 |a Online-Ressource  |b cr  |2 rdacarrier 
500 |a Online verfügbar: 18 June 2022, Artikelversion: 9 August 2022 
500 |a Gesehen am 31.10.2023 
520 |a Pathology plays a central role in the diagnosis of systemic mastocytosis (SM), its delineation from other neoplasms and reactive conditions, and in monitoring of SM under therapy. The morphologic hallmark of SM is the accumulation of spindle-shaped, hypogranulated mast cells (MCs) in bone marrow (BM) and other extracutaneous tissues. Four of the 5 World Health Organization-defined diagnostic criteria (ie, compact MC aggregates [=major criterion]; atypical MC morphology; activating KIT point mutations; aberrant expression of CD25 and/or CD2 and/or CD30 in MCs [=minor criteria]) can be addressed by the pathologist. The final classification of SM variants as either BM mastocytosis, indolent SM, smoldering SM, aggressive SM (ASM), SM with an associated hematologic neoplasm (SM-AHN), or MC leukemia (MCL) has important prognostic significance and requires the integration of certain morphological, clinical, radiological, and biochemical data, referred to as B- and C-findings. Substantial diagnostic challenges may be posed to the pathologist and clinician especially in the so-called advanced SM variants, that is, ASM, MCL, and SM-AHN. In this article, updated recommendations of the EU-US Cooperative Group regarding standards of pathology in the diagnosis of SM, presented during the year 2020 Working Conference held in September in Vienna, are reported. 
650 4 |a Associated hematologic neoplasm 
650 4 |a CD117 
650 4 |a CD25 
650 4 |a Diagnosis 
650 4 |a Diagnostic criteria 
650 4 |a Immunohistochemistry 
650 4 |a Mast cell 
650 4 |a Mastocytosis 
650 4 |a p.D816V 
650 4 |a Pathology 
650 4 |a Tryptase 
700 1 |a George, Tracy I.  |e VerfasserIn  |4 aut 
700 1 |a Kluin, Philip  |e VerfasserIn  |4 aut 
700 1 |a Reiter, Andreas  |d 1964-  |e VerfasserIn  |0 (DE-588)172629551  |0 (DE-627)697563766  |0 (DE-576)133488594  |4 aut 
700 1 |a Schwaab, Juliana  |d 1982-  |e VerfasserIn  |0 (DE-588)1051912687  |0 (DE-627)787019399  |0 (DE-576)407558764  |4 aut 
700 1 |a Panse, Jens  |e VerfasserIn  |4 aut 
700 1 |a Brockow, Knut  |e VerfasserIn  |4 aut 
700 1 |a Hartmann, Karin  |e VerfasserIn  |4 aut 
700 1 |a Sperr, Wolfgang R.  |e VerfasserIn  |4 aut 
700 1 |a Kristensen, Thomas  |e VerfasserIn  |4 aut 
700 1 |a Nedoszytko, Boguslaw  |e VerfasserIn  |4 aut 
700 1 |a Carter, Melody  |e VerfasserIn  |4 aut 
700 1 |a Bonadonna, Patrizia  |e VerfasserIn  |4 aut 
700 1 |a Lyons, Jonathan J.  |e VerfasserIn  |4 aut 
700 1 |a Kluin-Nelemans, Hanneke C.  |e VerfasserIn  |4 aut 
700 1 |a Hermine, Olivier  |e VerfasserIn  |4 aut 
700 1 |a Akin, Cem  |e VerfasserIn  |4 aut 
700 1 |a Broesby-Olsen, Sigurd  |e VerfasserIn  |4 aut 
700 1 |a Hoermann, Gregor  |e VerfasserIn  |4 aut 
700 1 |a Triggiani, Massimo  |e VerfasserIn  |4 aut 
700 1 |a Butterfield, Joseph H.  |e VerfasserIn  |4 aut 
700 1 |a Jawhar, Mohamad  |d 1986-  |e VerfasserIn  |0 (DE-588)1046172905  |0 (DE-627)775847747  |0 (DE-576)399437061  |4 aut 
700 1 |a Gotlib, Jason  |e VerfasserIn  |4 aut 
700 1 |a Metcalfe, Dean D.  |e VerfasserIn  |4 aut 
700 1 |a Orfao, Alberto  |e VerfasserIn  |4 aut 
700 1 |a Arock, Michel  |e VerfasserIn  |4 aut 
700 1 |a Valent, Peter  |e VerfasserIn  |4 aut 
700 1 |a Horny, Hans-Peter  |e VerfasserIn  |4 aut 
773 0 8 |i Enthalten in  |t The journal of allergy and clinical immunology. In practice  |d Amsterdam [u.a.] : Elsevier, 2013  |g 10(2022), 8 vom: Aug., Seite 1986-1998.e2  |h Online-Ressource  |w (DE-627)757132758  |w (DE-600)2728366-5  |w (DE-576)392331748  |x 2213-2201  |7 nnas  |a Standards of pathology in the diagnosis of systemic mastocytosis: recommendations of the EU-US Cooperative Group 
773 1 8 |g volume:10  |g year:2022  |g number:8  |g month:08  |g pages:1986-1998.e2  |g extent:13  |a Standards of pathology in the diagnosis of systemic mastocytosis: recommendations of the EU-US Cooperative Group 
856 4 0 |u https://doi.org/10.1016/j.jaip.2022.05.036  |x Verlag  |x Resolving-System  |z lizenzpflichtig  |3 Volltext 
856 4 0 |u https://www.sciencedirect.com/science/article/pii/S2213219822005876  |x Verlag  |z lizenzpflichtig  |3 Volltext 
951 |a AR 
992 |a 20231031 
993 |a Article 
994 |a 2022 
998 |g 1046172905  |a Jawhar, Mohamad  |m 1046172905:Jawhar, Mohamad  |d 60000  |d 61200  |e 60000PJ1046172905  |e 61200PJ1046172905  |k 0/60000/  |k 1/60000/61200/  |p 22 
998 |g 1051912687  |a Schwaab, Juliana  |m 1051912687:Schwaab, Juliana  |d 60000  |d 61200  |e 60000PS1051912687  |e 61200PS1051912687  |k 0/60000/  |k 1/60000/61200/ 
998 |g 172629551  |a Reiter, Andreas  |m 172629551:Reiter, Andreas  |d 60000  |d 61200  |e 60000PR172629551  |e 61200PR172629551  |k 0/60000/  |k 1/60000/61200/  |p 4 
999 |a KXP-PPN1868862240  |e 4400395006 
BIB |a Y 
SER |a journal 
JSO |a {"type":{"media":"Online-Ressource","bibl":"article-journal"},"person":[{"given":"Karl","display":"Sotlar, Karl","roleDisplay":"VerfasserIn","family":"Sotlar","role":"aut"},{"role":"aut","family":"George","roleDisplay":"VerfasserIn","display":"George, Tracy I.","given":"Tracy I."},{"role":"aut","family":"Kluin","roleDisplay":"VerfasserIn","display":"Kluin, Philip","given":"Philip"},{"role":"aut","roleDisplay":"VerfasserIn","family":"Reiter","display":"Reiter, Andreas","given":"Andreas"},{"display":"Schwaab, Juliana","given":"Juliana","role":"aut","family":"Schwaab","roleDisplay":"VerfasserIn"},{"given":"Jens","display":"Panse, Jens","roleDisplay":"VerfasserIn","family":"Panse","role":"aut"},{"display":"Brockow, Knut","given":"Knut","role":"aut","roleDisplay":"VerfasserIn","family":"Brockow"},{"given":"Karin","display":"Hartmann, Karin","family":"Hartmann","roleDisplay":"VerfasserIn","role":"aut"},{"roleDisplay":"VerfasserIn","family":"Sperr","role":"aut","given":"Wolfgang R.","display":"Sperr, Wolfgang R."},{"given":"Thomas","display":"Kristensen, Thomas","roleDisplay":"VerfasserIn","family":"Kristensen","role":"aut"},{"display":"Nedoszytko, Boguslaw","given":"Boguslaw","role":"aut","roleDisplay":"VerfasserIn","family":"Nedoszytko"},{"family":"Carter","roleDisplay":"VerfasserIn","role":"aut","given":"Melody","display":"Carter, Melody"},{"display":"Bonadonna, Patrizia","given":"Patrizia","role":"aut","roleDisplay":"VerfasserIn","family":"Bonadonna"},{"given":"Jonathan J.","display":"Lyons, Jonathan J.","family":"Lyons","roleDisplay":"VerfasserIn","role":"aut"},{"given":"Hanneke C.","display":"Kluin-Nelemans, Hanneke C.","roleDisplay":"VerfasserIn","family":"Kluin-Nelemans","role":"aut"},{"role":"aut","family":"Hermine","roleDisplay":"VerfasserIn","display":"Hermine, Olivier","given":"Olivier"},{"roleDisplay":"VerfasserIn","family":"Akin","role":"aut","given":"Cem","display":"Akin, Cem"},{"role":"aut","roleDisplay":"VerfasserIn","family":"Broesby-Olsen","display":"Broesby-Olsen, Sigurd","given":"Sigurd"},{"display":"Hoermann, Gregor","given":"Gregor","role":"aut","family":"Hoermann","roleDisplay":"VerfasserIn"},{"role":"aut","roleDisplay":"VerfasserIn","family":"Triggiani","display":"Triggiani, Massimo","given":"Massimo"},{"role":"aut","family":"Butterfield","roleDisplay":"VerfasserIn","display":"Butterfield, Joseph H.","given":"Joseph H."},{"role":"aut","roleDisplay":"VerfasserIn","family":"Jawhar","display":"Jawhar, Mohamad","given":"Mohamad"},{"display":"Gotlib, Jason","given":"Jason","role":"aut","roleDisplay":"VerfasserIn","family":"Gotlib"},{"family":"Metcalfe","roleDisplay":"VerfasserIn","role":"aut","given":"Dean D.","display":"Metcalfe, Dean D."},{"role":"aut","roleDisplay":"VerfasserIn","family":"Orfao","display":"Orfao, Alberto","given":"Alberto"},{"display":"Arock, Michel","given":"Michel","role":"aut","family":"Arock","roleDisplay":"VerfasserIn"},{"given":"Peter","display":"Valent, Peter","roleDisplay":"VerfasserIn","family":"Valent","role":"aut"},{"role":"aut","family":"Horny","roleDisplay":"VerfasserIn","display":"Horny, Hans-Peter","given":"Hans-Peter"}],"note":["Online verfügbar: 18 June 2022, Artikelversion: 9 August 2022","Gesehen am 31.10.2023"],"id":{"doi":["10.1016/j.jaip.2022.05.036"],"eki":["1868862240"]},"relHost":[{"pubHistory":["1.2013 -"],"type":{"media":"Online-Ressource","bibl":"periodical"},"note":["Gesehen am 13.12.13"],"part":{"text":"10(2022), 8 vom: Aug., Seite 1986-1998.e2","volume":"10","year":"2022","issue":"8","extent":"13","pages":"1986-1998.e2"},"physDesc":[{"extent":"Online-Ressource"}],"titleAlt":[{"title":"The journal of allergy and clinical immunology / In practice"}],"title":[{"title":"The journal of allergy and clinical immunology","partname":"In practice","title_sort":"journal of allergy and clinical immunology"}],"recId":"757132758","disp":"Standards of pathology in the diagnosis of systemic mastocytosis: recommendations of the EU-US Cooperative GroupThe journal of allergy and clinical immunology. In practice","id":{"eki":["757132758"],"issn":["2213-2201"],"zdb":["2728366-5"]},"origin":[{"publisher":"Elsevier","dateIssuedKey":"2013","publisherPlace":"Amsterdam [u.a.]","dateIssuedDisp":"2013-"}],"language":["eng"]}],"recId":"1868862240","title":[{"title_sort":"Standards of pathology in the diagnosis of systemic mastocytosis: recommendations of the EU-US Cooperative Group","title":"Standards of pathology in the diagnosis of systemic mastocytosis: recommendations of the EU-US Cooperative Group"}],"name":{"displayForm":["Karl Sotlar, Tracy I. George, Philip Kluin, Andreas Reiter, Juliana Schwaab, Jens Panse, Knut Brockow, Karin Hartmann, Wolfgang R. Sperr, Thomas Kristensen, Boguslaw Nedoszytko, Melody Carter, Patrizia Bonadonna, Jonathan J. Lyons, Hanneke C. Kluin-Nelemans, Olivier Hermine, Cem Akin, Sigurd Broesby-Olsen, Gregor Hoermann, Massimo Triggiani, Joseph H. Butterfield, Mohamad Jawhar, Jason Gotlib, Dean D. Metcalfe, Alberto Orfao, Michel Arock, Peter Valent, Hans-Peter Horny"]},"physDesc":[{"extent":"13 S."}],"language":["eng"],"origin":[{"dateIssuedDisp":"August 2022","dateIssuedKey":"2022"}]} 
SRT |a SOTLARKARLSTANDARDSO2022 

Similar Items