Meningeal involvement in Wegener's granulomatosis confirmed and monitored by positive circulating antineutrophil cytoplasm in cerebrospinal fluid

MRI and CSF investigations revealed meningeal involvement in a 29-year-old patient with biopsy-confirmed Wegener's granulomatosis. The intracranial manifestation of Wegener's granulomatosis was supported by the detection of pathologic circulating antineutrophil cytoplasm (c-ANCA) in the CS...

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Hauptverfasser: Spranger, Matthias (VerfasserIn) , Schwab, Stefan (VerfasserIn) , Meinck, Hans-Michael (VerfasserIn) , Tischendorf, Matthias (VerfasserIn) , Sis, Jeanne (VerfasserIn) , Breitbart, Andreas (VerfasserIn) , Andrassy, Konrad (VerfasserIn)
Dokumenttyp: Article (Journal)
Sprache:Englisch
Veröffentlicht: January 1, 1997
In: Neurology
Year: 1997, Jahrgang: 48, Heft: 1, Pages: 263-265
ISSN:1526-632X
DOI:10.1212/WNL.48.1.263
Online-Zugang:Verlag, lizenzpflichtig, Volltext: https://doi.org/10.1212/WNL.48.1.263
Verlag, lizenzpflichtig, Volltext: https://n.neurology.org/content/48/1/263
Volltext
Verfasserangaben:M. Spranger, S. Schwab, H.-M. Meinck, M. Tischendorf, J. Sis, A. Breitbart, K. Andrassy

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520 |a MRI and CSF investigations revealed meningeal involvement in a 29-year-old patient with biopsy-confirmed Wegener's granulomatosis. The intracranial manifestation of Wegener's granulomatosis was supported by the detection of pathologic circulating antineutrophil cytoplasm (c-ANCA) in the CSF. We monitored disease activity by c-ANCA measurement in the CSF. After repeated cycles of intrathecal administration of methotrexate and corticoids, progression of meningeal infiltration stopped, and CSF c-ANCA titers became negative. - NEUROLOGY 1997;48: 263-265 
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