Aberrant gene activation in synovial sarcoma relies on SSX specificity and increased PRC1.1 stability
The SS18-SSX fusion drives oncogenic transformation in synovial sarcoma by bridging SS18, a member of the mSWI/SNF (BAF) complex, to Polycomb repressive complex 1 (PRC1) target genes. Here we show that the ability of SS18-SSX to occupy H2AK119ub1-rich regions is an intrinsic property of its SSX C te...
Gespeichert in:
| Hauptverfasser: | , , , , , , , , , , , , , , |
|---|---|
| Dokumenttyp: | Article (Journal) |
| Sprache: | Englisch |
| Veröffentlicht: |
21 September 2023
|
| In: |
Nature structural & molecular biology
Year: 2023, Pages: 1-33 |
| ISSN: | 1545-9985 |
| DOI: | 10.1038/s41594-023-01096-3 |
| Online-Zugang: | Verlag, kostenfrei, Volltext: https://doi.org/10.1038/s41594-023-01096-3 Verlag, kostenfrei, Volltext: https://www.nature.com/articles/s41594-023-01096-3 
|
| Verfasserangaben: | Nezha S. Benabdallah, Vineet Dalal, R. Wilder Scott, Fady Marcous, Afroditi Sotiriou, Felix K. F. Kommoss, Anastasija Pejkovska, Ludmila Gaspar, Lena Wagner, Francisco J. Sánchez-Rivera, Monica Ta, Shelby Thornton, Torsten O. Nielsen, T. Michael Underhill, Ana Banito |
MARC
| LEADER | 00000caa a22000002c 4500 | ||
|---|---|---|---|
| 001 | 1869526163 | ||
| 003 | DE-627 | ||
| 005 | 20240307043114.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231107s2023 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1038/s41594-023-01096-3 |2 doi | |
| 035 | |a (DE-627)1869526163 | ||
| 035 | |a (DE-599)KXP1869526163 | ||
| 035 | |a (OCoLC)1425209712 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rda | ||
| 041 | |a eng | ||
| 084 | |a 32 |2 sdnb | ||
| 100 | 1 | |a Benabdallah, Nezha S. |e VerfasserIn |0 (DE-588)1308977875 |0 (DE-627)1869530306 |4 aut | |
| 245 | 1 | 0 | |a Aberrant gene activation in synovial sarcoma relies on SSX specificity and increased PRC1.1 stability |c Nezha S. Benabdallah, Vineet Dalal, R. Wilder Scott, Fady Marcous, Afroditi Sotiriou, Felix K. F. Kommoss, Anastasija Pejkovska, Ludmila Gaspar, Lena Wagner, Francisco J. Sánchez-Rivera, Monica Ta, Shelby Thornton, Torsten O. Nielsen, T. Michael Underhill, Ana Banito |
| 264 | 1 | |c 21 September 2023 | |
| 300 | |a 33 | ||
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a Computermedien |b c |2 rdamedia | ||
| 338 | |a Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Gesehen am 07.11.2023 | ||
| 520 | |a The SS18-SSX fusion drives oncogenic transformation in synovial sarcoma by bridging SS18, a member of the mSWI/SNF (BAF) complex, to Polycomb repressive complex 1 (PRC1) target genes. Here we show that the ability of SS18-SSX to occupy H2AK119ub1-rich regions is an intrinsic property of its SSX C terminus, which can be exploited by fusion to transcriptional regulators beyond SS18. Accordingly, SS18-SSX recruitment occurs in a manner that is independent of the core components and catalytic activity of BAF. Alternative SSX fusions are also recruited to H2AK119ub1-rich chromatin and reproduce the expression signatures of SS18-SSX by engaging with transcriptional activators. Variant Polycomb repressive complex 1.1 (PRC1.1) acts as the main depositor of H2AK119ub1 and is therefore required for SS18-SSX occupancy. Importantly, the SSX C terminus not only depends on H2AK119ub1 for localization, but also further increases it by promoting PRC1.1 complex stability. Consequently, high H2AK119ub1 levels are a feature of murine and human synovial sarcomas. These results uncover a critical role for SSX-C in mediating gene deregulation in synovial sarcoma by providing specificity to chromatin and further enabling oncofusion binding by enhancing PRC1.1 stability and H2AK119ub1 deposition. | ||
| 650 | 4 | |a Cancer | |
| 650 | 4 | |a Chromatin | |
| 650 | 4 | |a Genomic analysis | |
| 650 | 4 | |a Histone post-translational modifications | |
| 650 | 4 | |a Molecular biology | |
| 700 | 1 | |a Dalal, Vineet |d 1991- |e VerfasserIn |0 (DE-588)1199958816 |0 (DE-627)1682102513 |4 aut | |
| 700 | 1 | |a Scott, R. Wilder |e VerfasserIn |4 aut | |
| 700 | 1 | |a Marcous, Fady |e VerfasserIn |4 aut | |
| 700 | 1 | |a Sotiriou, Afroditi |e VerfasserIn |4 aut | |
| 700 | 1 | |a Kommoss, Felix |d 1991- |e VerfasserIn |0 (DE-588)1171010427 |0 (DE-627)1040361315 |0 (DE-576)512915164 |4 aut | |
| 700 | 1 | |a Pejkovska, Anastasija |d 1995- |e VerfasserIn |0 (DE-588)1309071454 |0 (DE-627)1869662261 |4 aut | |
| 700 | 1 | |a Gaspar, Ludmila |e VerfasserIn |4 aut | |
| 700 | 1 | |a Wagner, Lena |e VerfasserIn |0 (DE-588)1171497334 |0 (DE-627)1040567320 |0 (DE-576)513766464 |4 aut | |
| 700 | 1 | |a Sánchez-Rivera, Francisco J. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Ta, Monica |e VerfasserIn |4 aut | |
| 700 | 1 | |a Thornton, Shelby |e VerfasserIn |4 aut | |
| 700 | 1 | |a Nielsen, Torsten O. |e VerfasserIn |4 aut | |
| 700 | 1 | |a Underhill, T. Michael |e VerfasserIn |4 aut | |
| 700 | 1 | |a Banito, Ana |e VerfasserIn |0 (DE-588)1204036594 |0 (DE-627)1689159316 |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Nature structural & molecular biology |d London [u.a.] : Nature Publishing Group, 2004 |g (2023), Seite 1-33 |h Online-Ressource |w (DE-627)37683126X |w (DE-600)2131437-8 |w (DE-576)109293967 |x 1545-9985 |7 nnas |a Aberrant gene activation in synovial sarcoma relies on SSX specificity and increased PRC1.1 stability |
| 773 | 1 | 8 | |g year:2023 |g pages:1-33 |g extent:33 |a Aberrant gene activation in synovial sarcoma relies on SSX specificity and increased PRC1.1 stability |
| 856 | 4 | 0 | |u https://doi.org/10.1038/s41594-023-01096-3 |x Verlag |x Resolving-System |z kostenfrei |3 Volltext |
| 856 | 4 | 0 | |u https://www.nature.com/articles/s41594-023-01096-3 |x Verlag |z kostenfrei |3 Volltext |
| 951 | |a AR | ||
| 992 | |a 20231107 | ||
| 993 | |a Article | ||
| 994 | |a 2023 | ||
| 998 | |g 1204036594 |a Banito, Ana |m 1204036594:Banito, Ana |d 140000 |e 140000PB1204036594 |k 0/140000/ |p 15 |y j | ||
| 998 | |g 1309071454 |a Pejkovska, Anastasija |m 1309071454:Pejkovska, Anastasija |d 140000 |e 140000PP1309071454 |k 0/140000/ |p 7 | ||
| 998 | |g 1171010427 |a Kommoss, Felix |m 1171010427:Kommoss, Felix |d 910000 |d 912000 |e 910000PK1171010427 |e 912000PK1171010427 |k 0/910000/ |k 1/910000/912000/ |p 6 | ||
| 998 | |g 1199958816 |a Dalal, Vineet |m 1199958816:Dalal, Vineet |d 140000 |e 140000PD1199958816 |k 0/140000/ |p 2 | ||
| 999 | |a KXP-PPN1869526163 |e 4403690238 | ||
| BIB | |a Y | ||
| SER | |a journal | ||
| JSO | |a {"language":["eng"],"person":[{"family":"Benabdallah","given":"Nezha S.","display":"Benabdallah, Nezha S.","role":"aut"},{"display":"Dalal, Vineet","role":"aut","family":"Dalal","given":"Vineet"},{"display":"Scott, R. Wilder","role":"aut","family":"Scott","given":"R. Wilder"},{"role":"aut","display":"Marcous, Fady","given":"Fady","family":"Marcous"},{"family":"Sotiriou","given":"Afroditi","display":"Sotiriou, Afroditi","role":"aut"},{"role":"aut","display":"Kommoss, Felix","given":"Felix","family":"Kommoss"},{"display":"Pejkovska, Anastasija","role":"aut","family":"Pejkovska","given":"Anastasija"},{"role":"aut","display":"Gaspar, Ludmila","given":"Ludmila","family":"Gaspar"},{"role":"aut","display":"Wagner, Lena","given":"Lena","family":"Wagner"},{"family":"Sánchez-Rivera","given":"Francisco J.","display":"Sánchez-Rivera, Francisco J.","role":"aut"},{"role":"aut","display":"Ta, Monica","given":"Monica","family":"Ta"},{"display":"Thornton, Shelby","role":"aut","family":"Thornton","given":"Shelby"},{"given":"Torsten O.","family":"Nielsen","role":"aut","display":"Nielsen, Torsten O."},{"given":"T. Michael","family":"Underhill","role":"aut","display":"Underhill, T. Michael"},{"family":"Banito","given":"Ana","display":"Banito, Ana","role":"aut"}],"physDesc":[{"extent":"33 S."}],"type":{"bibl":"article-journal","media":"Online-Ressource"},"id":{"doi":["10.1038/s41594-023-01096-3"],"eki":["1869526163"]},"title":[{"title":"Aberrant gene activation in synovial sarcoma relies on SSX specificity and increased PRC1.1 stability","title_sort":"Aberrant gene activation in synovial sarcoma relies on SSX specificity and increased PRC1.1 stability"}],"relHost":[{"note":["Gesehen am 01.03.05"],"disp":"Aberrant gene activation in synovial sarcoma relies on SSX specificity and increased PRC1.1 stabilityNature structural & molecular biology","language":["eng"],"title":[{"title_sort":"Nature structural & molecular biology","title":"Nature structural & molecular biology"}],"physDesc":[{"extent":"Online-Ressource"}],"recId":"37683126X","origin":[{"publisherPlace":"London [u.a.]","dateIssuedKey":"2004","publisher":"Nature Publishing Group","dateIssuedDisp":"2004-"}],"part":{"text":"(2023), Seite 1-33","pages":"1-33","year":"2023","extent":"33"},"pubHistory":["11.2004 -"],"id":{"zdb":["2131437-8"],"issn":["1545-9985"],"eki":["37683126X"]},"type":{"media":"Online-Ressource","bibl":"periodical"}}],"name":{"displayForm":["Nezha S. Benabdallah, Vineet Dalal, R. Wilder Scott, Fady Marcous, Afroditi Sotiriou, Felix K. F. Kommoss, Anastasija Pejkovska, Ludmila Gaspar, Lena Wagner, Francisco J. Sánchez-Rivera, Monica Ta, Shelby Thornton, Torsten O. Nielsen, T. Michael Underhill, Ana Banito"]},"recId":"1869526163","note":["Gesehen am 07.11.2023"],"origin":[{"dateIssuedKey":"2023","dateIssuedDisp":"21 September 2023"}]} | ||
| SRT | |a BENABDALLAABERRANTGE2120 | ||